DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and Grm3

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_862898.1	Gene:	Grm3 / 108069	MGIID:	1351340	Length:	879	Species:	Mus musculus

Alignment Length:	915	Identity:	367/915 - (40%)
Similarity:	539/915 - (58%)	Gaps:	62/915 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 LMLPLSSADGSGKYLRSLPDSVSFQNDRLYATQPQRHWPVKREAIVEGDVILGGLMMVHSR-EDS 409
            |||.|.|..    :|.||.|                |..::||..:|||::||||..::.: ..:
Mouse    10 LMLALFSKG----FLVSLGD----------------HNFMRREIKIEGDLVLGGLFPINEKGTGT 54

  Fly   410 ITCGPIMPQGGIQALEAMLFTIDRINREQ-LLPNITLGAHILDDCDKDSYGLEMAVDFIKGSISN 473
            ..||.|....|||.||||||.||.||::. |||.:.||.||||.|.:|:|.||.:::|::.|::.
Mouse    55 EECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTK 119

  Fly   474 IDDAEYHCN------KTQVRKVISGVVGAASSVTSIQVANLLRLFRIPQVSYFSTSPELSNKQRF 532
            :|:|||.|.      :..:..:|:||:|.:.|..|||||||||||:|||:||.|||.:||:|.|:
Mouse   120 VDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRY 184

  Fly   533 EYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYGIKAFEELEELLARHNICIAIKEKLVK 597
            :||:||:|.|.||.|||.||::...|:|||.:..|.:||....|..|:.....|||||..|| |.
Mouse   185 DYFARTVPPDFYQAKAMAEILRYFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEK-VG 248

  Fly   598 DSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMRAVRRANATGSFSWIGSDGWSARNLV 662
            .|.:.:  :||:::::||.||.||..::|....:.|:::.|..|.||  ||:|:.||||.|:..:
Mouse   249 RSNIRK--SYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRVNA--SFTWVASDGWGAQESI 309

  Fly   663 SDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNPWFVEFWEDHFQCRYPGSTSTPYNNY 727
            ....|....|.::::..::|||.|:.||.||...||.|||||.:|||..|||.....     .|:
Mouse   310 VKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNK-----RNH 369

  Fly   728 TKQCTTKERLSRQNTDFEDQLQFVSDAVMAFAYALRDMHRDLCGGGPSLCEAMKPTKGADLLK-Y 791
            .:.|.....:...|.:.|.::.||.:||.|.|:||..|.|.||.....||:|||...|..|.| |
Mouse   370 RQICDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDY 434

  Fly   792 LRKVEF-----EGLSGDEF-RFDGNGDGPARYNIIHFKQSQAGQYHWVKVGEYTEGELRLNMTEV 850
            |.|:.|     .....|.. :||..|||..|||:.:| |...|:|.::|||.:.| .|.|::..:
Mouse   435 LLKINFTAPFNPNKGADSIVKFDTYGDGMGRYNVFNF-QHIGGKYSYLKVGHWAE-TLYLDVDSI 497

  Fly   851 KFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAH 915
            .:.|.|  .|.|.||.||...:.|....|:.|||.|..|..|:  :..||..|..|..|..|.|.
Mouse   498 HWSRNS--VPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYE--YLVDEFTCMDCGPGQWPTAD 558

  Fly   916 KQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIF 980
            ...|..:||.|:|.|.|||||.:..:..|.:.|..|:.||::||:||:|:||||||.||||.|:.
Mouse   559 LSGCYNLPEDYIRWEDAWAIGPVTIACLGFMCTCIVITVFIKHNNTPLVKASGRELCYILLFGVS 623

  Fly   981 MCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISPKSQ 1045
            :.|.:||..:.||:.::||::|.|:|..|.:.|:|||||||.|||||...|..|:||.||||.||
Mouse   624 LSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQ 688

  Fly  1046 LVICACLVSVQILINGVWMVI-APSHAMHHYPTREDNLLVCDSYIDASYMIAFSYPIFLIVICTV 1109
            :.||..|:.|||::..||::: .|....:..|.:.:.:::..:..|:|.:|:.:|.:.|:::|||
Mouse   689 VFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTV 753

  Fly  1110 YAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSMSVTISLSASVTIACL 1174
            ||..|||.||.|||:|.|||||||||:|||||:|:::.|::...::.|:|.:::|||..|.:.||
Mouse   754 YAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCL 818

  Fly  1175 FSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPS-SMMAAAVVTAATCAQEEKIQKHITPTN 1238
            |:||::|:|.:|::||....:   :.|....:||..: |..:|:......|...|.:.      :
Mouse   819 FAPKVHIVLFQPQKNVVTHRL---HLNRFSVSGTATTYSQSSASTYVPTVCNGREVLD------S 874

  Fly  1239 TENSL 1243
            |.:||
Mouse   875 TTSSL 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	194/468 (41%)
		ANF_receptor	422..820	CDD:279440	173/411 (42%)
		NCD3G	861..910	CDD:284890	17/48 (35%)
		7tm_3	945..1181	CDD:278433	110/236 (47%)
Grm3	NP_862898.1	PBP1_mGluR_groupII	33..494	CDD:380598	195/472 (41%)
		Glutamate binding. /evidence=ECO:0000250	172..174		0/1 (0%)
		NCD3G	505..555	CDD:400103	19/51 (37%)
		7tmC_mGluR3	575..828	CDD:320564	117/252 (46%)
		TM helix 1	576..600	CDD:320564	9/23 (39%)
		TM helix 2	612..633	CDD:320564	11/20 (55%)
		TM helix 3	642..664	CDD:320564	11/21 (52%)
		TM helix 4	690..706	CDD:320564	6/15 (40%)
		TM helix 5	733..756	CDD:320564	9/22 (41%)
		TM helix 6	768..790	CDD:320564	16/21 (76%)
		TM helix 7	797..822	CDD:320564	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710