DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and Grm2

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001153825.1	Gene:	Grm2 / 108068	MGIID:	1351339	Length:	872	Species:	Mus musculus

Alignment Length:	893	Identity:	385/893 - (43%)
Similarity:	537/893 - (60%)	Gaps:	74/893 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 PVKREAIVEGDVILGGLMMVHSR----EDSITCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNI 443
            |.|:...:|||::||||..||.:    |:   |||:....|||.||||||.:|||||: .|||.:
Mouse    21 PAKKVLTLEGDLVLGGLFPVHQKGGPAEE---CGPVNEHRGIQRLEAMLFALDRINRDPHLLPGV 82

  Fly   444 TLGAHILDDCDKDSYGLEMAVDFIKGSISNIDDAEYH-------CNKTQVRKVISGVVGAASSVT 501
            .|||||||.|.||::.||.|:||::.|:|...|...|       ...:.....|:||:|.:.|..
Mouse    83 RLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATLSDAPTAITGVIGGSYSDV 147

  Fly   502 SIQVANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYE 566
            |||||||||||:|||:||.|||.:||:|.|::||:||:|.|.:|.|||.||::...|:|||.:..
Mouse   148 SIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVAS 212

  Fly   567 ESNY---GIKAFEELEELLAR-HNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFG 627
            |.:|   ||:||    ||.|| .|||:|..||:.:....|   |::.:|:.||.||.||.|::|.
Mouse   213 EGDYGETGIEAF----ELEARARNICVATSEKVGRAMSRA---AFEGVVRALLQKPSARVAVLFT 270

  Fly   628 SDQEVRQVMRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLS 692
            ..::.|:::.|.:|.||  ||:|:.||||.|...|....|...||.::::..:.|:..|..||.:
Mouse   271 RSEDARELLAATQRLNA--SFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQN 333

  Fly   693 LTVENNQRNPWFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNTDFEDQ--LQFVSDAV 755
            |...||.|||||.||||:.|:|.:          ..:.|...   |.:...||.:  :.||.:||
Mouse   334 LDPWNNSRNPWFREFWEERFRCSF----------RQRDCAAH---SLRAVPFEQESKIMFVVNAV 385

  Fly   756 MAFAYALRDMHRDLCGGGPSLCEAMKPTKGADLLK-YLRKVEFEGL-----SGDEFRFDGNGDGP 814
            .|.|:||.:|||.||.....||:||:|..|..|.| ::..|:|:..     :.||.|||..|||.
Mouse   386 YAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGI 450

  Fly   815 ARYNIIHFKQSQAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKP---PESVCSLPCLVGQAKKY 876
            .||||..:.::..|:|.:.|||.:.|| |.|:.:.:.:  .||..   |.|.||.|||..:.|..
Mouse   451 GRYNIFTYLRAGNGRYRYQKVGYWAEG-LTLDTSIIPW--ASPSAGTLPASRCSEPCLQNEVKSV 512

  Fly   877 VEGESCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFS 941
            ..||.|||.|..|..|:.|.  ||..|..|.||..|:|....|..:|:.|:|...|||:|.:..:
Mouse   513 QPGEVCCWLCIPCQPYEYRL--DEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIA 575

  Fly   942 ATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVG 1006
            ..|.|.||||:|||||||.||:|:||||||.||||.|:|:||.:||..:.||:..||.::|.|:|
Mouse   576 CLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLG 640

  Fly  1007 FCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVI-APSH 1070
            ..|:|.|:|||||||||||||...::.|:||.||||.||:.||..|:|.|:||...|:|: ||..
Mouse   641 TAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGI 705

  Fly  1071 AMHHYPTREDNLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTC 1135
            .....|.|.:.:.:..::.|||.:.:.:|.:.||.:||:||..|||.||.|||:|.|||||||||
Mouse   706 GKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTC 770

  Fly  1136 VIWLAFVPLYFGTANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMP-PRY 1199
            :|||||:|:::.|::...::.|:|.|::|||.||.:.|||:|||:|||.:|::||.....| .|:
Mouse   771 IIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRF 835

  Fly  1200 GNMHRTA----GTGPSSMMAAAVVTAATCAQEEKIQKHITPTNTENSL 1243
            |:....|    |.|..|.:...|     |...|.:.      :|.:||
Mouse   836 GSAAPRASANLGQGSGSQLVPTV-----CNGREVVD------STTSSL 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	202/477 (42%)
		ANF_receptor	422..820	CDD:279440	178/417 (43%)
		NCD3G	861..910	CDD:284890	21/48 (44%)
		7tm_3	945..1181	CDD:278433	125/236 (53%)
Grm2	NP_001153825.1	PBP1_mGluR_groupII	30..480	CDD:107370	201/475 (42%)
		ANF_receptor	60..456	CDD:279440	178/417 (43%)
		Glutamate binding. /evidence=ECO:0000250	166..168		0/1 (0%)
		NCD3G	498..545	CDD:284890	22/48 (46%)
		7tm_3	579..816	CDD:278433	125/236 (53%)
		Important for interaction with HTR2A. /evidence=ECO:0000250	677..685		4/7 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720