DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and vn2r1p

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	XP_012818896.1	Gene:	vn2r1p / 100496607	XenbaseID:	XB-GENE-876508	Length:	908	Species:	Xenopus tropicalis

Alignment Length:	891	Identity:	244/891 - (27%)
Similarity:	418/891 - (46%)	Gaps:	104/891 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 DVILGGLMMVHSR----EDSITCGPIMPQ------GGIQALEAMLFTIDRINREQ-LLPNITLGA 447
            ::|:||:...|.|    .||....|..|:      ..::...||:|.|::||::: :|||||||.
Frog    45 ELIIGGMFPFHFRTILQNDSAMEEPKSPKCEGFNFRSLRWARAMIFAINKINKQRDILPNITLGY 109

  Fly   448 HILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHCNKTQVRKVISGVVGAASSVTSIQVANLLRLF 512
            .|.|.|...|..:|..:.|:.|  .|.....:.|:   ....::.||||..|..||..|.:|.|:
Frog   110 QIFDTCFTISKAVEGTLSFLTG--QNETHPNFRCS---AGAPLAAVVGAGGSALSIATARILGLY 169

  Fly   513 RIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESN---YGIKA 574
            ..|||.|.|:...||:|.:|..|.|||.||..|.|.:..:|...||::|..|..:.:   ||||.
Frog   170 YFPQVGYASSCSVLSDKFQFPSFLRTIASDTTQSKGIAALVTYFGWTWVGTIAADDDYGKYGIKL 234

  Fly   575 FEELEELLARHNICIAIKEKLV----KDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQV 635
            |:|..|   ::.:||:..|.|.    |||       .|.|| ..:.|..|...:||.||.::..:
Frog   235 FKEEVE---KNGVCISFSETLPRIYNKDS-------IDKIV-ATIRKSTANIIVIFSSDIDLSSL 288

  Fly   636 MRAVRRANATGSFSWIGSDGWSARNLVSDDYEPE----VEGTLSVQPQANPVRGFEEYFLSLTVE 696
            |.|:...|.||. ::|.|:.|:...|::   :|:    :.||:....|...:.||||:...:..|
Frog   289 MEALAETNITGK-TYISSEAWTTSALIA---KPKHFHFLGGTIGFAVQRASIPGFEEFLHDIHPE 349

  Fly   697 NNQRNPWFVEFWEDHFQCRYPGSTSTPYNNYTKQ--------------CTTKERLSRQNTDFEDQ 747
            :. .:....||||:.|.|.:|.:.:..|.|.:.:              ||.:|.|:.....:.|.
Frog   350 HG-NDDLVYEFWEEAFNCTWPTNRALFYTNISLEAAMAGRKRDVSPIPCTGRENLNTSLNTYSDV 413

  Fly   748 LQF-----VSDAVMAFAYALRDMHRDLC--GGGP---SLCEAMKPTKGADLLKYLRKVEFEGLSG 802
            .:.     |..||...|:||.|:  |:|  ..||   :.|..:...:...|:.||:|.:|..|:.
Frog   414 SELRITYNVYKAVYTIAHALHDL--DVCVPKHGPFPNNECANVLDFEPWQLMYYLKKAKFTSLNN 476

  Fly   803 DEFRFDGNGDGPARYNIIHFKQSQAGQYHWVKVGEY---TEG-ELRLNMTEVKFKRLSPKPPESV 863
            :...||.:||....|::::::........:||:|.|   |.| |.:::.:.:.:...:..||.||
Frog   477 ETISFDDSGDIKGHYDVLNWQWKDNQTMSFVKIGYYKDLTSGYEFKIDNSSILWNTPNTMPPRSV 541

  Fly   864 CSLPCLVGQAKKYVEGES-CCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEI-Y 926
            ||..|:.|..|...:||. ||:.|..|...:|.:..|...|..|......::|:..| .:.|: :
Frog   542 CSESCIPGTRKGIRQGEPVCCFDCIACADGEITNETDARECISCPSDFWSNSHRNEC-VLKEVEF 605

  Fly   927 LRPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVL 991
            |..:.|..|..:..|..|..:.:....|::.:.:|.:|:|:.|.||:::...:...:..:...|.
Frog   606 LATDEALGITLIFLSVFGASLVIAFTVVYIMYRETALVKANSRSLSFLIQVSLVFTFMTSVLFVG 670

  Fly   992 KPTNIVCAIQRFGVGFCFTVVYAALLTKTNRIARIFKAGKQSAKRP------SFISPKSQLVICA 1050
            ||....|..::..:...|::..:::|.||    .:....|:|||..      ..:.|..|:::..
Frog   671 KPEQWSCMARQITLALGFSLCLSSILGKT----IVLMLRKKSAKSKLAERGHDALKPVYQIIVAV 731

  Fly  1051 CLVSVQILINGVWMVIAPSHAMHHYPTREDN----LLVCDSYIDASYMIAFSYPIFLIVICTVYA 1111
            ..:::|..|...:::|.|...   |...|..    :|.|:..........|.:.:||.::..:.|
Frog   732 IGLTIQAGICTAYLLIYPPWV---YKNMESQNVKIILECNEGSIEFLCSMFGFDVFLAILSFITA 793

  Fly  1112 VLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSMSVTISLSASV-TIACLF 1175
            .:.||:|:.|||:|.|.|.|....::|::|||.|..|.....:.:...::   |::|. .:.|:|
Frog   794 FIARKLPDNFNEAKFITFGMLVFFIVWISFVPAYLSTRGKFKVAVEIFAI---LASSFGLLGCIF 855

  Fly  1176 SPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSSMMAAAVVTA 1221
            .||.||||::||||..:.:     |.  |.|....|:...:|.:|:
Frog   856 VPKSYIILLKPERNTEEIV-----GG--RAATNDKSAPATSASITS 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	148/502 (29%)
		ANF_receptor	422..820	CDD:279440	132/433 (30%)
		NCD3G	861..910	CDD:284890	17/49 (35%)
		7tm_3	945..1181	CDD:278433	55/246 (22%)
vn2r1p	XP_012818896.1	PBP1_CaSR	47..530	CDD:380587	148/505 (29%)
		NCD3G	538..591	CDD:369426	18/52 (35%)
		7tmC_V2R-like	611..866	CDD:320407	63/264 (24%)
		TM helix 1	611..636	CDD:320407	5/24 (21%)
		TM helix 2	648..669	CDD:320407	3/20 (15%)
		TM helix 3	678..702	CDD:320407	4/27 (15%)
		TM helix 4	728..744	CDD:320407	2/15 (13%)
		TM helix 5	771..797	CDD:320407	4/25 (16%)
		TM helix 6	805..828	CDD:320407	9/22 (41%)
		TM helix 7	833..858	CDD:320407	4/27 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910