DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and grm1

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	XP_017949676.2	Gene:	grm1 / 100495945	XenbaseID:	XB-GENE-980107	Length:	1172	Species:	Xenopus tropicalis

Alignment Length:	1155	Identity:	401/1155 - (34%)
Similarity:	591/1155 - (51%)	Gaps:	163/1155 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 LNNMNLMLPLSSADGSGKYLRSLPDSVSFQNDRLYATQPQRHWPVKREAIVEGDVILGGLMMVH- 404
            |..:||:|.|....|...:...|....:|   .:.|:.|      :..|.::||:|:|.|..||
Frog    13 LKMVNLLLILMMTVGLDIFYGGLFGRNTF---LVCASSP------RSVARMDGDIIIGALFSVHH 68

  Fly   405 ----SREDSITCGPIMPQGGIQALEAMLFTIDRINREQ-LLPNITLGAHILDDCDKDSYGLEMAV 464
                .:.....||.|..|.|||.:|||..|:|:||.:| ||||||||..|.|.|...|..||.::
Frog    69 QPPAEKVPERKCGEIREQYGIQRVEAMFHTLDQINMDQNLLPNITLGTEIRDSCWHSSVALEQSI 133

  Fly   465 DFIKGSISNIDDAEYHCNKT---------QVRKVISGVVGAASSVTSIQVANLLRLFRIPQVSYF 520
            :||:.|:.::.|.:....|.         :::|.|:||:|..||..:|||.|||:||.|||::|.
Frog   134 EFIRDSLISMRDEKDGAGKCLDATPTPHGRIKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYS 198

  Fly   521 STSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYGIKAFEELEELLARH 585
            :||.:||:|..::||.|.:|||..|.:||::||||..|:|||.::.|.|||....|..:|:.|:.
Frog   199 ATSIDLSDKTLYKYFLRVVPSDILQARAMLDIVKRYNWTYVSAVHTEGNYGESGMEAFKEMAAQE 263

  Fly   586 NICIAIKEKLVKDSGVAEDIAYDNIVQKLLTK-PRARGAIIFGSDQEVRQVMRAVRRANATGSFS 649
            .:|||..:|:..::|   :..:|.:::||..: |:||..|.|.....||.::.|:||....|.|.
Frog   264 GLCIAHTDKIYSNAG---ERNFDRLLKKLRERLPKARVVICFCEGMTVRGILMAMRRLGVAGEFL 325

  Fly   650 WIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNPWFVEFWEDHFQC 714
            .||||||:.|:.|.:.||.|..|.::::.|:..|..|:.|:|.|.::.|.|||||.|||:..|||
Frog   326 LIGSDGWADRDEVIEGYEAEANGGITMKLQSAEVMSFDTYYLGLRLDTNSRNPWFTEFWQHRFQC 390

  Fly   715 RYPGSTSTPYNN--YTKQCTTKERLSRQNTDFEDQLQFVSDAVMAFAYALRDMHRDLCGGGPSLC 777
            |.||.   |..|  :.|.|...|.| .:|...:.::.||.:|:.|.|:.|.|||..||.|...||
Frog   391 RIPGH---PQENRSFKKICKGNETL-EENYVQDSKMGFVINAIYAMAHGLHDMHSALCPGHVGLC 451

  Fly   778 EAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFKQSQAGQYHWVKVGEYTEGE 842
            :||||..|:.||::|.|..|.|:||::..||..||.|.||:|::.:|.:..:|.:|::|.:.||
Frog   452 DAMKPIDGSKLLEFLIKASFLGISGEDVWFDEKGDAPGRYDIMNLQQIEPNRYDYVQIGAWHEG- 515

  Fly   843 LRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGE-SCCWHCFNCTTYQIRHPDDETHCKLC 906
             .|:|.:.:.:........||||.||..|:.|...:|| ||||.|..|...:.  ..||..||.|
Frog   516 -ILSMDDYRIQANKSGIVRSVCSDPCSKGEIKVIRKGEVSCCWICTPCKENEF--VQDEFTCKAC 577

  Fly   907 KLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTPIVRASGREL 971
            ..|..|:.....|.|||..||:.....:|.|:|||..|||:|:||..:|:.:.|||:|::|.|||
Frog   578 DQGAWPNPGLTGCEPIPVKYLQWSDIESIIAVAFSCLGILITMFVTLIFILYRDTPVVKSSSREL 642

  Fly   972 SYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNRIARIFKAGKQS--A 1034
            .||:|||||:.|...|.|:.|||...|.:||..||....:.|:||:|||||||||....|:.  .
Frog   643 CYIILAGIFLGYICPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICT 707

  Fly  1035 KRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHYPTREDNLLVCDSYIDASYMIAFSY 1099
            ::|.|:|..:|:||.:.|:|:|:.:....:::.|...:..||:.::..|:|:: .:...:....|
Frog   708 RKPRFMSACAQVVIASILISLQLSLVVSLIIMEPPMPILSYPSIKEVYLICNT-SNLGVVAPLGY 771

  Fly  1100 PIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSMSVTIS 1164
            ...||:.||.||..||.:|..|||:|:|.|||||||:|||||||:||| :|:   :|.:.|..:|
Frog   772 NGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFG-SNY---KIITTSFAVS 832

  Fly  1165 LSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSSMMAAAVVTAATCAQEEK 1229
            ||.:|.:.|:|:||:|||:.:||||||.:........||...|..|             |.
Frog   833 LSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKTP-------------CR---- 880

  Fly  1230 IQKHITPTNTENSLKTKKLCEMATQTISSIITSLDINAYNQIPYADQYVPNNATTATTTPTDKGS 1294
                   :||..|:..:|                              .|:...|         :
Frog   881 -------SNTFLSIFRRK------------------------------KPSTGNT---------N 899

  Fly  1295 GNGNSNSNSNTNG-------------SSNSNSNSNGDGDVATEQVVANNNKINQRQHGQPAVAFA 1346
            .||.|.|.|...|             |.:..|...|....|   |:....|..|.|:  .::.|:
Frog   900 SNGKSVSWSEPGGRQVQKGQHMWHRLSVHVKSKETGSNQTA---VIKPLTKGYQAQN--KSLTFS 959

  Fly  1347 ITSTNNHISGPAATITTTAATGETTTEALVATITTPLATVDGSETMSVAPNNGHGNNGSQRPPVL 1411
            .||||        |:.......|..|....|.:::|.:.:             |....|..||
Frog   960 DTSTN--------TLYNVEEEDENETGRFNAMMSSPTSII-------------HRRLNSTPPP-- 1001

  Fly  1412 QTNLXLNAQQLQQ--QLLKEQQRQQAELQTQHPQQQHGTQSSSSDTASTG 1459
                   :|:..:  ..|.||..:...||.....|.||.    .|..|||
Frog  1002 -------SQEFDEGSMYLSEQVSKSLPLQKSIIDQLHGV----IDRFSTG 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	191/471 (41%)
		ANF_receptor	422..820	CDD:279440	170/410 (41%)
		NCD3G	861..910	CDD:284890	21/49 (43%)
		7tm_3	945..1181	CDD:278433	102/237 (43%)
grm1	XP_017949676.2	PBP1_mGluR_groupI	49..522	CDD:380597	193/481 (40%)
		NCD3G	533..583	CDD:400103	22/51 (43%)
		7tmC_mGluR1	603..852	CDD:320565	111/253 (44%)
		TM helix 1	604..628	CDD:320565	12/23 (52%)
		TM helix 2	640..661	CDD:320565	12/20 (60%)
		TM helix 3	670..692	CDD:320565	9/21 (43%)
		TM helix 4	720..736	CDD:320565	5/15 (33%)
		TM helix 5	761..784	CDD:320565	6/22 (27%)
		TM helix 6	796..818	CDD:320565	16/21 (76%)
		TM helix 7	821..846	CDD:320565	9/27 (33%)
		GluR_Homer-bdg	1123..1172	CDD:402304
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910