DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and grm3

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	XP_031754896.1	Gene:	grm3 / 100492610	XenbaseID:	XB-GENE-977445	Length:	878	Species:	Xenopus tropicalis

Alignment Length:	894	Identity:	367/894 - (41%)
Similarity:	535/894 - (59%)	Gaps:	61/894 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 VKREAIVEGDVILGGLMMVHSREDSI-TCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNITLGA 447
            |::|...|||::||||..::.:...: .||.|....|||.||||||.||:|||: .|||.:.||.
Frog    27 VRKEIKFEGDLVLGGLFPINEKGGGMDECGRINEDRGIQRLEAMLFAIDQINRDSSLLPGVKLGV 91

  Fly   448 HILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHC--NKTQVRK----VISGVVGAASSVTSIQVA 506
            ||||.|.:|:|.||.:::|::.|::.:|:|||.|  ....:::    .|:||:|.:.|..|||||
Frog    92 HILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENSPLPIAGVIGGSYSSVSIQVA 156

  Fly   507 NLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYG 571
            ||||||.|||:||.|||.:||:|.|::||:||:|.|.||.|||.||::...|:|||.:..|.:||
Frog   157 NLLRLFHIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYG 221

  Fly   572 IKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVM 636
            ....|..|......|||||..|| |..|.:.:  :|||.:::||.||.|:..::|....:.|:::
Frog   222 ETGIEAFEHEARLRNICIATSEK-VGRSNLKK--SYDNAIKELLQKPNAKVVVLFMRSDDTRELL 283

  Fly   637 RAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRN 701
            .|..|.||  ||:||.||||.|:..:....|....|.::::..::||:.|::||.|||..||.||
Frog   284 AAANRFNA--SFTWIASDGWGAQESIVKGNEHIAYGAITLELASHPVKEFDKYFQSLTPYNNHRN 346

  Fly   702 PWFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNTDFEDQLQFVSDAVMAFAYALRDMH 766
            |||.:||:..|||.....     |...|.|..:..::..|.:.|.::.||.:||.|.||||..|.
Frog   347 PWFKDFWQQKFQCSLQNK-----NQQVKFCDKRLNINSSNYEQESKIMFVINAVYAMAYALHQMQ 406

  Fly   767 RDLCGGGPSLCEAMKPTKGADLLK-YLRKVEFEG-----LSGDEF-RFDGNGDGPARYNIIHFKQ 824
            |.:|.....||:|||...|..|.| ||.||.|..     .:.|.. :||..|||...||:.:| |
Frog   407 RTVCPNTNILCDAMKVLDGKKLYKDYLLKVNFTAPFIPPSNTDSIVKFDAYGDGIGLYNVFNF-Q 470

  Fly   825 SQAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHCFNC 889
            ...|:|.::|:|::.| .|.|::..:::.:  ...|.|.||.||...:.|....|:.|||.|..|
Frog   471 YHNGKYSYLKIGQWAE-TLSLDVDIIQWSK--SLVPTSQCSDPCAPNEMKNMQPGDVCCWICIPC 532

  Fly   890 TTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGV 954
            ..|:  :..||..|..|..|..|.|....|..:||.|::.|.|||||.:..:..|.:.|..|.||
Frog   533 EKYE--YLADEFTCIDCGEGRWPTADLTSCFDLPEDYIKWEDAWAIGPVTIACLGFVCTCLVGGV 595

  Fly   955 FVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTK 1019
            |:::|.||:|:||||||.||||.|:||||.:||..:.||:.::|.::|.|:|..|.|.|:|||||
Frog   596 FIKNNSTPLVKASGRELCYILLIGVFMCYCMTFFFIAKPSPVICTLRRLGLGTSFVVCYSALLTK 660

  Fly  1020 TNRIARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVIA-PSHAMHHYPTREDNLL 1083
            ||||||||...|..|:||.|||||||:|||..|:||||::..||:::. |....:..|.:.:.::
Frog   661 TNRIARIFSGVKDGAQRPKFISPKSQVVICLSLISVQIVVVSVWLMLEFPGTRRYTLPEKRETVI 725

  Fly  1084 VCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGT 1148
            :..:..|:|.:|:.:|.:.|:::|||||..|||.||.|||:|.|||||||||:|||||:|:::.|
Frog   726 LKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVT 790

  Fly  1149 ANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSSM 1213
            ::...::.|:|.:::|||..|.:.|||:||::|||.:|::||....:   :.|....:||
Frog   791 SSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRL---HLNRFSVSGT----- 847

  Fly  1214 MAAAVVTAATCAQEEKIQKHITPTNTENSLKTKKLC---EMATQTISSI 1259
                    ||...:.....|.|||          :|   |:...|.||:
Frog   848 --------ATTYSQSSASAHYTPT----------ICNGGEVLDSTTSSL 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	195/468 (42%)
		ANF_receptor	422..820	CDD:279440	175/411 (43%)
		NCD3G	861..910	CDD:284890	17/48 (35%)
		7tm_3	945..1181	CDD:278433	117/236 (50%)
grm3	XP_031754896.1	PBP1_mGluR_groupII	31..492	CDD:380598	196/472 (42%)
		NCD3G	503..553	CDD:400103	19/51 (37%)
		7tmC_mGluR_group2	573..826	CDD:320411	125/252 (50%)
		TM helix 1	574..598	CDD:320411	10/23 (43%)
		TM helix 2	610..631	CDD:320411	14/20 (70%)
		TM helix 3	640..662	CDD:320411	11/21 (52%)
		TM helix 4	688..704	CDD:320411	8/15 (53%)
		TM helix 5	731..754	CDD:320411	9/22 (41%)
		TM helix 6	766..788	CDD:320411	16/21 (76%)
		TM helix 7	795..820	CDD:320411	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010