DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and grm4

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	XP_031752707.1	Gene:	grm4 / 100491626	XenbaseID:	XB-GENE-6045861	Length:	914	Species:	Xenopus tropicalis

Alignment Length:	903	Identity:	386/903 - (42%)
Similarity:	547/903 - (60%)	Gaps:	70/903 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 VEGDVILGGLMMVHSR-EDSITCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNITLGAHILDDC 453
            ::||:|||||..||.| .|...||.:..:.||..||||||.:||||.: :|||||||||.|||.|
Frog    35 IDGDLILGGLFPVHGRGSDGRACGELKKEKGIHRLEAMLFALDRINSDLELLPNITLGARILDTC 99

  Fly   454 DKDSYGLEMAVDFIKGSISNIDDAEYHCNK------TQVRKVISGVVGAASSVTSIQVANLLRLF 512
            .:|::.||.::.|::..|.. |.||..|..      .|..:|| ||:||:||..||.|||:||||
Frog   100 SRDTHALEQSLSFVQPLIDK-DRAEVRCLSGGNPIIAQPERVI-GVIGASSSSVSIMVANILRLF 162

  Fly   513 RIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNY---GIKA 574
            :||||||.||:||||:..|:::|||.:|||.||.:|||:|||.:.|||||.:..|.:|   |::|
Frog   163 KIPQVSYASTAPELSDNSRYDFFSRVVPSDTYQAQAMVDIVKALKWSYVSTLASEGSYGESGVEA 227

  Fly   575 FEELEELLARHNICIAIKEKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMRAV 639
            |  :::.....::|:|...|:.:|:...:   :|.|:::||....||..|||.|:.::|:|:.|.
Frog   228 F--IQKSREDGSLCVAQSVKIPRDAKPGD---FDKIIRRLLETSNARAVIIFASEDDIRRVLAAA 287

  Fly   640 RRANATGSFSWIGSDGWSARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNPWF 704
            :|||.||.|.|:|||.|.::.......|...||.:::.|:...|:||:.||.|.|::||:||.||
Frog   288 KRANQTGHFMWVGSDSWGSKISPVHLQEEVAEGAVTILPKRATVKGFDRYFTSRTLDNNRRNVWF 352

  Fly   705 VEFWEDHFQCRYPGSTSTPYNNYTKQCTTKERLSRQNT-DFEDQLQFVSDAVMAFAYALRDMHRD 768
            .|||||:|.||. ...|.....:.|:||.:||:...:. :.|.::|||.|||.:.||||..||:.
Frog   353 AEFWEDNFHCRL-SRNSLRRGGHGKKCTNQERIGVGSAYEQEGKVQFVIDAVYSMAYALHTMHKT 416

  Fly   769 LCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFKQSQAGQYHWV 833
            :|.|...||..|.|..|.:||||:|.|.|.|::|....|:.|||.|.||.|..: |...|...:.
Frog   417 VCPGSVGLCSRMDPVDGVELLKYIRSVNFTGIAGTPVTFNENGDAPGRYEIYQY-QINNGSTEYR 480

  Fly   834 KVGEYTEGELRLNMTEVKFKRLS------------PKPPESVCSLPCLVGQAKKYVEGESCCWHC 886
            .:|::.: .|.|.:.::.:..||            ||.|.|:||.||..|:.||.|:|..|||||
Frog   481 VIGQWAD-HLHLKIDQMHWPDLSSSSSSSVSSSHLPKIPPSICSQPCRPGERKKVVKGIPCCWHC 544

  Fly   887 FNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFV 951
            ..|..||  :..|...||.|.|...|:.:...|.|||.|.|...|.||:..:..:..||:.||.|
Frog   545 ERCDGYQ--YQLDTYTCKRCPLHMRPNVNHTSCIPIPIIKLEWSSPWAVVPLLLAVLGIIATLVV 607

  Fly   952 MGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAAL 1016
            :|.|:|:||||||:||||||||:||:|||:||..||.:|.:|....|:::|..:|...::.||||
Frog   608 VGTFMRYNDTPIVKASGRELSYVLLSGIFLCYVNTFIMVAQPGFGTCSLRRVFLGLGMSISYAAL 672

  Fly  1017 LTKTNRIARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHY------ 1075
            |||||||.|||:.||:|...|.:|||.|||||.|.|.|:|:|...||.::.||..:..|
Frog   673 LTKTNRIYRIFEQGKRSVSAPRYISPSSQLVITASLSSIQLLGVLVWFLVDPSRPIVDYENQRTP 737

  Fly  1076 -PTREDNLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWL 1139
             |.....:|.|| ..|.|.:....|.:.|:|.|||||:.||.:||.|||:|.|||||||||:|||
Frog   738 DPQLTRGVLKCD-ISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWL 801

  Fly  1140 AFVPLYFGT---ANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGN 1201
            ||:|::|||   |..:.::.|::::::||||||::..|:.||:|:||..||:||     |.|..:
Frog   802 AFIPIFFGTAQSAEKMHIQTTTLTISVSLSASVSLGMLYMPKVYVILFHPEQNV-----PKRKRS 861

  Fly  1202 MHRTAGTGPSSMMAAAVVTAATCAQEEKIQKHITPTNTENSLKTKKLCE-MATQTISS 1258
            :             .|||||||.:.:...:....|    |.....:||: |..|.:::
Frog   862 L-------------KAVVTAATMSNKFTQKGSYRP----NGEAKTELCDNMEVQALAT 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	203/465 (44%)
		ANF_receptor	422..820	CDD:279440	182/408 (45%)
		NCD3G	861..910	CDD:284890	23/48 (48%)
		7tm_3	945..1181	CDD:278433	122/245 (50%)
grm4	XP_031752707.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10393
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000883
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000