DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and grm2

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	XP_002935662.2	Gene:	grm2 / 100380092	XenbaseID:	XB-GENE-1012087	Length:	864	Species:	Xenopus tropicalis

Alignment Length:	925	Identity:	368/925 - (39%)
Similarity:	528/925 - (57%)	Gaps:	96/925 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 LMLP-LSSADGSGKYLRSLPDSVSFQNDRLYATQPQRHWPVKREAIVEGDVILGGLMMVHSR-ED 408
            |:|| |.:..|.|                          |.:.|..|:||.::|||..||.: ..
Frog     9 LLLPVLETGSGGG--------------------------PPRPEIRVDGDFVIGGLFPVHEKGAP 47

  Fly   409 SITCGPIMPQGGIQALEAMLFTIDRINRE-QLLPNITLGAHILDDCDKDSYGLEMAVDFIKGSIS 472
            ...||.:....|:|.||||||.:|.||.: .|||.:.|||||||.|.||:|.||.|::.::||::
Frog    48 GAECGRMNEHRGLQRLEAMLFALDAINNDPHLLPGLQLGAHILDTCSKDTYALEQALELVRGSLT 112

  Fly   473 NIDDAEYHCN------KTQVRKVISGVVGAASSVTSIQVANLLRLFRIPQVSYFSTSPELSNKQR 531
            ..|..::.|.      ..:....||||:|.:.|..|||||||||||:|.|:||.|||.:||:|.|
Frog   113 RTDGPQHLCPDGSYAIHGESPTAISGVIGGSYSDVSIQVANLLRLFQIAQISYASTSAKLSDKSR 177

  Fly   532 FEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNY---GIKAFEELEELLARHNICIAIKE 593
            :::|:||:|.|.||.|||.||::...|:|||.:..|.:|   ||:|||  :|..|| |||||..|
Frog   178 YDFFARTVPPDFYQAKAMAEILRYFNWTYVSTVASEGDYGETGIEAFE--QEARAR-NICIATSE 239

  Fly   594 KLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMRAVRRANATGSFSWIGSDGWSA 658
            |:.:.....   .:..:::.|..||.||..::|...::.|:::.|.:..|.  ||:|:.||||.|
Frog   240 KVGRSMNKK---TFAGVIKALQQKPSARVVVLFTKIEDARELLAAAQELNV--SFTWVASDGWGA 299

  Fly   659 RNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNPWFVEFWEDHFQCRYPGSTSTP 723
            ...|....|...||.::::..:.|:..|.|||.||..:||.|||||.||||:.|||
Frog   300 LESVVLGSEQVAEGAITIELASYPLMEFSEYFQSLHPDNNTRNPWFREFWENKFQC--------- 355

  Fly   724 YNNYTKQCTTKERLSRQNTDFEDQLQFVSDAVMAFAYALRDMHRDLCGGGPSLCEAMKPTKGADL 788
              :.|....::..|.:...:.|.::.||.:||.|.|:||.:|...:|.....||..|.|..|...
Frog   356 --SLTSPGCSEHSLRQVKFEQESKIMFVVNAVYAMAHALHNMQHAVCLNSTYLCPNMNPPNGKRF 418

  Fly   789 LK-YLRKVEFEGL-----SGDEFRFDGNGDGPARYNIIHFKQSQAGQYHWVKVGEYTEGELRLNM 847
            .: |:..|:|...     :....|||..|||..||||.:| |:..|:||:.|||.:.| ||.||.
Frog   419 YRDYILNVKFNAPFPPPDTKSTVRFDKYGDGIGRYNIFNF-QNTGGRYHYQKVGYWAE-ELTLNT 481

  Fly   848 TEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGESCCWHCFNCTTYQIRHPDDETHCKLCKLGTLP 912
            :.:.:.:.:  .|.|.||.||...:.|....|:.|||.|.:|..|:..  .||..||.|.||..|
Frog   482 SLIPWAKSA--VPVSQCSDPCKKNEVKSMQPGDVCCWICISCQPYEFL--VDEFTCKDCGLGYWP 542

  Fly   913 DAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLA 977
            :.....|..:|:.|:|...|||:|.:..|..|:|.||||:||||::|:||||:||||||.||||.
Frog   543 NLDLTGCYELPQEYIRWGDAWAVGPVCLSCLGLLSTLFVIGVFVQNNNTPIVKASGRELCYILLC 607

  Fly   978 GIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISP 1042
            |:.:||.:||..:.||:..||.::|.|:|..|.:.|:|||||||||||||...:...:||.||||
Frog   608 GVLLCYAMTFIFISKPSTSVCTLRRLGLGTSFAICYSALLTKTNRIARIFSGARDGVQRPRFISP 672

  Fly  1043 KSQLVICACLVSVQILINGVWMVIAPSHAMHHYPTREDN--------LLVCDSYIDASYMIAFSY 1099
            .||:.||..|:|.|:|:..:|::..|.      .||:|.        .|.|:|. |.|.:|:.||
Frog   673 ASQVGICLVLISCQLLVVLIWLLFEPP------GTRKDTAPDKRYIVTLKCNSG-DGSMLISLSY 730

  Fly  1100 PIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSMSVTIS 1164
            .:.|:::||:||..|||.||.|||:|.|||||||||:|||||:|:|:.|::...::.|::.|::|
Frog   731 NVLLVLLCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIYYVTSSDYRVQTTTLCVSVS 795

  Fly  1165 LSASVTIACLFSPKLYIILIRPERNVRQSMMPPRYGNMHRTAGTGPSSMMAAAVVTAAT-CAQEE 1228
            ||.||.:.|||:|||:||:.:|::||....:.     .:|.:.|||.....:||....| |...|
Frog   796 LSGSVVLGCLFTPKLHIIIFQPQKNVTSHRIA-----TNRFSATGPGGTHGSAVQYVPTVCNGRE 855

  Fly  1229 KIQKHITPTNTENSL 1243
            .:.      :|.:||
Frog   856 VVD------STTSSL 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	187/470 (40%)
		ANF_receptor	422..820	CDD:279440	164/413 (40%)
		NCD3G	861..910	CDD:284890	19/48 (40%)
		7tm_3	945..1181	CDD:278433	122/243 (50%)
grm2	XP_002935662.2	Periplasmic_Binding_Protein_type1	27..479	CDD:385651	187/472 (40%)
		NCD3G	492..542	CDD:369426	21/51 (41%)
		7tmC_mGluR2	562..815	CDD:320563	130/259 (50%)
		TM helix 1	562..587	CDD:320563	14/24 (58%)
		TM helix 2	599..620	CDD:320563	12/20 (60%)
		TM helix 3	629..653	CDD:320563	12/23 (52%)
		TM helix 4	675..695	CDD:320563	8/19 (42%)
		TM helix 5	720..746	CDD:320563	10/26 (38%)
		TM helix 6	754..777	CDD:320563	17/22 (77%)
		TM helix 7	784..809	CDD:320563	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920