DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mtt and grm1b

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001289181.2	Gene:	grm1b / 100150246	ZFINID:	ZDB-GENE-090821-3	Length:	1158	Species:	Danio rerio

Alignment Length:	1069	Identity:	379/1069 - (35%)
Similarity:	558/1069 - (52%)	Gaps:	145/1069 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 LYATQPQRHWPVKREAI----------VEGDVILGGLMMVHSREDS-----ITCGPIMPQGGIQA 423
            |:.|  :.|...:|.|:          ::||:|:|.|..||.:..:     ..||.|..|.|||.
Zfish    16 LFCT--RLHLSTERSAVSRAASRSVARMDGDIIIGALFSVHHQPSAEKVAERKCGEIREQYGIQR 78

  Fly   424 LEAMLFTIDRINRE-QLLPNITLGAHILDDCDKDSYGLEMAVDFIKGSISNIDD----------A 477
            :|||.:|:||||.: .||||||||..|.|.|...|..||.:::||:.|:.:|.|          .
Zfish    79 VEAMFYTLDRINSDPYLLPNITLGCEIRDSCWHSSVALEQSIEFIRDSLISIRDEREGPKWCVEG 143

  Fly   478 EYHCNKTQVRKVISGVVGAASSVTSIQVANLLRLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSD 542
            .........:|.|:||:|..||..:|||.|||:||.|||::|.:||.:||:|..::||.|.:|||
Zfish   144 NPSAQPPATKKPIAGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSIDLSDKTLYKYFLRVVPSD 208

  Fly   543 HYQVKAMVEIVKRMGWSYVSIIYEESNYGIKAFEELEELLARHNICIAIKEKLVKDSGVAEDIAY 607
            ..|.:|:::||||..|:|||.::.|.|||....|..:||.::..:|||..:|:..::|   :..:
Zfish   209 TLQARALLDIVKRYNWTYVSAVHTEGNYGESGMEAFKELASQEGLCIAHSDKIYSNAG---EKHF 270

  Fly   608 DNIVQKLLTK-PRARGAIIFGSDQEVRQVMRAVRRANATGSFSWIGSDGWSARNLVSDDYEPEVE 671
            |.:::||..: |:||..:.|.....||.::.|:||....|.|..||||||:.|:.|.:.||.|..
Zfish   271 DRLLRKLRERLPKARVVVCFCEGMTVRGLLMAMRRLGVAGEFLLIGSDGWADRDEVVEGYEEEAV 335

  Fly   672 GTLSVQPQANPVRGFEEYFLSLTVENNQRNPWFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKER 736
            |.::|:.|...|..|.:|||.|.:..|.|||||.|||:..||||..|... ...||.|.|:..|.
Zfish   336 GGITVKLQTEEVTSFNDYFLKLRLATNNRNPWFAEFWQHRFQCRLAGHPQ-ENTNYRKNCSGYES 399

  Fly   737 LSRQNTDFEDQLQFVSDAVMAFAYALRDMHRDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLS 801
            | ..|...:.::.||.:|:.|.|:.|.|||..||.|...|||.|.|..|:.||.:|.|..|.|:|
Zfish   400 L-EDNYVQDSKMGFVINAIYAMAHGLHDMHEHLCPGHVGLCEEMDPIDGSKLLDFLLKTSFAGVS 463

  Fly   802 GDEFRFDGNGDGPARYNIIHFKQSQAGQYHWVKVGEYTEGELRLNMTEVKFKRLSPKPPESVCSL 866
            |::..||.|||.|.||:|::.:..:.|.:.::.||.:.||.|.::...::..|  .:...||||.
Zfish   464 GEDVWFDENGDSPGRYDIMNLQYVEPGVFDYINVGSWHEGILSIDDYMIQMNR--SEMVRSVCSE 526

  Fly   867 PCLVGQAKKYVEGE-SCCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYL--- 927
            ||..|:.|...:|| ||||.|..|...:  :..||..||.|:||..||...|.|.|:|..||
Zfish   527 PCSKGEIKVIRKGEVSCCWICTPCKDNE--YVQDEFTCKACELGWWPDEELQVCEPLPLRYLEWS 589

  Fly   928 RPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLK 992
            .|||   |.|:.||..|||||.||..||:.:.|||:|::|.|||.||:|||||:.|...|.|:.:
Zfish   590 HPES---IAAVVFSCLGILVTSFVTLVFILYRDTPVVKSSSRELCYIILAGIFLGYICPFTLIAR 651

  Fly   993 PTNIVCAIQRFGVGFCFTVVYAALLTKTNRIARIFKAGKQS--AKRPSFISPKSQLVICACLVSV 1055
            |:...|.:||..||...::.|:||:|||||||||....|:.  .::|.|:|..:|:||...|:|:
Zfish   652 PSIASCYLQRLLVGLSASMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVVIAFILISM 716

  Fly  1056 QILINGVWMVIAPSHAMHHYPTREDNLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEA 1120
            |:.:....:::.|...:..||:..:..|:|:: .:...:....|...||:.||.||..||.:|..
Zfish   717 QLTLEVTLIILEPPEPIKSYPSIREVFLICNT-SNMGMVAPLGYNGLLILSCTYYAFKTRNVPAN 780

  Fly  1121 FNESKHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIR 1185
            |||:|:|.|||||||:|||||||:||| :|:   :|.:.|.::|||.:|.:.|:|:||:|||:.:
Zfish   781 FNEAKYIAFTMYTTCIIWLAFVPIYFG-SNY---KIITTSFSVSLSVTVALGCMFTPKMYIIIAK 841

  Fly  1186 PERNVRQSMMPPRYGNMHRTAGTGPSSMMAAAVVTAATCAQEEKIQKHITPTNTENSLKTKKLCE 1250
            ||||||.:........||  .|.|..:..:.:::                     |..|.||
Zfish   842 PERNVRSAFTTSDVVRMH--VGDGKIACRSNSLL---------------------NMFKRKK--- 880

  Fly  1251 MATQTISSIITSLDINAYNQIPYADQYVPNNATTATTTPTDKGSGNGNSNSNSNTNGSSNSNSNS 1315
                                          ||           |||.|||..|.:.....|....
Zfish   881 ------------------------------NA-----------SGNANSNGKSVSWSEPGSRHPP 904

  Fly  1316 NGDG-------DVATEQVVANNNKINQ---RQHGQPAVAFAITSTNNHISGPAATITTTAATGE- 1369
            .|:.       .|..::..:|...|.:   ..:..|.:.|:..||.        |:...|...|
Zfish   905 KGEHMWHRLSVHVKKQEAGSNQTAIIKPLTNTYNNPGMEFSDLSTK--------TLYNVAEEDEI 961

  Fly  1370 -------TTTEALVATITTPLATVDGSET 1391
                   :.:..|:|.::.|:..|..:.|
Zfish   962 DPIRYNPSNSPHLMAPVSKPMKEVGANLT 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	189/470 (40%)
		ANF_receptor	422..820	CDD:279440	169/409 (41%)
		NCD3G	861..910	CDD:284890	22/49 (45%)
		7tm_3	945..1181	CDD:278433	102/237 (43%)
grm1b	NP_001289181.2	PBP1_mGluR_groupI	36..510	CDD:107369	189/478 (40%)
		NCD3G	521..571	CDD:311495	23/51 (45%)
		7tmC_mGluR1	591..840	CDD:320565	113/256 (44%)
		TM helix 1	591..616	CDD:320565	16/27 (59%)
		TM helix 2	628..649	CDD:320565	12/20 (60%)
		TM helix 3	658..682	CDD:320565	11/23 (48%)
		TM helix 4	706..726	CDD:320565	6/19 (32%)
		TM helix 5	749..775	CDD:320565	7/25 (28%)
		TM helix 6	783..806	CDD:320565	17/22 (77%)
		TM helix 7	809..834	CDD:320565	9/27 (33%)
		GluR_Homer-bdg	1108..1158	CDD:313760
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100392
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810