DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and olfcg1

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001153312.1	Gene:	olfcg1 / 100147940	ZFINID:	ZDB-GENE-060503-630	Length:	840	Species:	Danio rerio

Alignment Length:	845	Identity:	216/845 - (25%)
Similarity:	375/845 - (44%)	Gaps:	83/845 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 EGDVILGGLMMVHSRE-----------DSITCGPIMPQGGIQALEAMLFTIDRINR-EQLLPNIT 444
            :||:.:|.|..:.|:|           ..::|..:..: ..:..:.|:|.|:.||| :.||||::
Zfish    37 DGDITIGALFAILSKETLPSFQFTQKPQLLSCSSVNLR-DFRMTQIMIFAIEEINRSKSLLPNVS 100

  Fly   445 LGAHILDDCDKDSYGLEMAVDFIKGSISNIDDAEYHCNKTQVRKVISGVVGAASSVTSIQVANLL 509
            :|..|.|.|......:...:..:.|.....|..   ||.   ...|..::|...|..:|.::...
Zfish   101 IGYRIYDTCGSRMSAMSATMALMNGPEFTADKI---CNG---ESPIHAIIGETESSATIILSKTT 159

  Fly   510 RLFRIPQVSYFSTSPELSNKQRFEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYGIKA 574
            ..|:||.:|:.::...|||::.:..|.|||.||::|.:|:..|||..|||:|..:..:::||...
Zfish   160 GPFKIPVISHSASCECLSNRKIYPSFFRTIASDYHQGRALAFIVKHFGWSWVGTVNSDNDYGNNV 224

  Fly   575 FEELEELLARHNICI--AIK------EKLVKDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQE 631
            .........:..||:  ::|      |||.|             |.:.:.|..|:..:.|.|..|
Zfish   225 MAIFLNTAQKEGICVEYSVKFYRTEPEKLKK-------------VVETIKKSTAKVIVAFVSLVE 276

  Fly   632 VRQVMRAVRRANATGSFSWIGSDGW-SARNLVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTV 695
            :..::..:...|.|| |..||.:|| :.::|::......:.|:|....:...:.||.:|.:.
Zfish   277 MGLLIDQLSIQNITG-FQVIGGEGWITTKSLINSKSFHVLGGSLGFAFRKIIIEGFADYVIK--- 337

  Fly   696 ENNQRNPWFVEFWEDHFQCRYPGSTSTPYNNYTKQCTTKE---RLSRQNTDFEDQLQFVSD---A 754
                      .|||..|.|.   :....|:.|...|::.:   .|...|.|..:| ::.|:   |
Zfish   338 ----------TFWERDFPCL---TNEGNYSQYALTCSSYQDLFTLKHYNEDIPEQ-RYASNVYKA 388

  Fly   755 VMAFAYALRDMHRDLCGGGPSLCEAMKPTKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNI 819
            |.|.|::|.::.:.....|   ||.....:...:::.|:.|.|....||...||..|...|.|.:
Zfish   389 VYAVAHSLHNLLKCKENEG---CEKSLTMQPQQVVEALKNVNFTLKFGDRVWFDSTGGAVAHYEV 450

  Fly   820 IHFKQSQAGQYHWVKVGEYTEGEL------RLNMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVE 878
            ::::|...|.:.:.||| |.:..|      .||...:.:.....:.|.||||..|..|..|...:
Zfish   451 VNWQQDSDGSFQFKKVG-YFDASLPPDQSFMLNTKNIIWSGGQLERPRSVCSESCPPGTRKASQK 514

  Fly   879 GES-CCWHCFNCTTYQIRHPDDETHCKLCKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSA 942
            |.. ||:.|..|...:|.:..|..:||.|:.....:..|..|......:|.......|..:.||.
Zfish   515 GRPVCCYDCIPCAEGEISNETDSVNCKQCQGEYWSNVEKNKCVLKAVEFLSFTDFMGIVLVFFSL 579

  Fly   943 TGILVTLFVMGVFVRHNDTPIVRASGRELSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGF 1007
            .|:.:|:.|..:|....|||||:|:..|||::||..:.:|:..:...:.:||...|.::....|.
Zfish   580 FGVGLTVLVAILFYSKKDTPIVKANNSELSFLLLLSLTLCFLCSLTFIGRPTEWSCMLRHTAFGI 644

  Fly  1008 CFTVVYAALLTKTNRIARIFKAGKQSAKRPSFISPKSQLVICACLVSVQILINGVWMVIA---PS 1069
            .|.:..:.:|.||..:...|||....:....:..|..|.:.......:|:||..:|:.::   |.
Zfish   645 TFVLCISCVLGKTIVVLMAFKATLPGSNVMKWFGPVQQRLSVLAFTLIQVLICVLWLTMSSPFPY 709

  Fly  1070 HAMHHYPTREDNLLVCDSYIDASYMIAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTT 1134
            ..|.:|  :|..:|.|.......:.....|...|..:|.:.|.|.|.:|:.|||:|.|.|:|...
Zfish   710 KNMKYY--KEKIILECSLGSVIGFWAVLGYIGLLAALCFILAFLARTLPDNFNEAKFITFSMLIF 772

  Fly  1135 CVIWLAFVPLYFGTANHVPLRITSMSVTISLSASVTIACLFSPKLYIILIRPERNVRQSMMPPRY 1199
            |.:|:.|:|.|..:.....:.:...::..|...  .:.|:|.||.:||:.:||:|.:|.||...|
Zfish   773 CAVWVTFIPAYVSSPGKYTVAVEIFAILASTFG--LLFCIFVPKCHIIIFKPEQNTKQHMMGKNY 835

Fly 1200 1199
Zfish 836 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	119/486 (24%)
		ANF_receptor	422..820	CDD:279440	104/413 (25%)
		NCD3G	861..910	CDD:284890	17/49 (35%)
		7tm_3	945..1181	CDD:278433	62/238 (26%)
olfcg1	NP_001153312.1	PBP1_GPCR_family_C_like	41..483	CDD:153138	117/483 (24%)
		ANF_receptor	82..454	CDD:279440	104/411 (25%)
		NCD3G	497..548	CDD:284890	17/50 (34%)
		7tm_3	584..817	CDD:278433	62/236 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910