DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mtt and olfcj1

DIOPT Version :9

Sequence 1:	NP_001260806.1	Gene:	mtt / 35832	FlyBaseID:	FBgn0050361	Length:	1472	Species:	Drosophila melanogaster
Sequence 2:	NP_001103761.1	Gene:	olfcj1 / 100005028	ZFINID:	ZDB-GENE-060503-724	Length:	857	Species:	Danio rerio

Alignment Length:	882	Identity:	232/882 - (26%)
Similarity:	402/882 - (45%)	Gaps:	83/882 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 LSSADGSGKYLRSLPDSVSFQNDR-LYATQPQRHWPVKREAIVEGDVILGGLMMVH--------- 404
            ||:|:         |:..::..|. ||.::             ||:|.:||:...|
Zfish    15 LSAAE---------PECEAYMTDELLYFSK-------------EGNVSIGGVFSFHQNPVGVNPT 57

  Fly   405 --SREDSITCGPIMPQGGIQALEAMLFTIDRI-NREQLLPNITLGAHILDDCDKDSYGLEMAVDF 466
              :...:|.|..:.| |.:|....|:|.|:.| ||..|||...||..|.|.|......:..::..
Zfish    58 LRTNPGNIRCNGLDP-GELQYAITMIFAIEEINNRTDLLPGFILGYRIYDSCPSIPLSVGASLTL 121

  Fly   467 IKGSISNIDDAEYHCNKTQVRKVISGVVGAASSVTSIQVANLLRLFRIPQVSYFSTSPELSNKQR 531
            :.|.:    :.:..|...   ..:..|:|..:|.::|.:|..:..|:||.:|:.:|...|||:|:
Zfish   122 MNGQM----ETKKSCASP---SAVQAVIGETTSTSTIDIARTIGPFKIPVLSHSATCACLSNRQQ 179

  Fly   532 FEYFSRTIPSDHYQVKAMVEIVKRMGWSYVSIIYEESNYGIKAFEELEELLARHNICIAIKEKLV 596
            :..|.||||||:||.:|:|::|...||.:|..:....:||........|...:..||:.....:.
Zfish   180 YPSFFRTIPSDYYQSRALVKLVTYFGWKWVGAVRSMGDYGNNGMATFLEAAEKEGICVEYSVSIY 244

  Fly   597 KDSGVAEDIAYDNIVQKLLTKPRARGAIIFGSDQEVRQVMRAVRRANATGSFSWIGSDGW-SARN 660
            :.:...:.:...:|::|..:|.    .:.|....::..:::.:...|.|| :.|:||:|| :.|.
Zfish   245 RTNSREKILEVTDIIKKSTSKV----IVAFADGNDLDMLIKELYYQNVTG-YQWVGSEGWITYRF 304

  Fly   661 LVSDDYEPEVEGTLSVQPQANPVRGFEEYFLSLTVENNQRNPWFVEFWEDHFQCRYPGSTSTPYN 725
            |.:......|.|.:........:.|.:|:...........|...||.||..|.|.....|    :
Zfish   305 LATAINYAVVGGAIGFAVPNAYIPGLKEFITGSQPSLRPGNTGLVELWESVFDCTLNSQT----H 365

  Fly   726 NYTKQCTTKERLSRQNTDFED-----QLQFVSDAVMAFAYALRDMHRDLCGGGP---SLCEAMKP 782
            |.:|.|..:|.|:..||.|.|     .|..|.:||.|.|:|:.::.....|.||   ..|.....
Zfish   366 NASKICNGQESLANINTRFTDVSDASLLNNVYNAVYAVAHAVEELLTCEKGKGPFHKKTCAEKGK 430

  Fly   783 TKGADLLKYLRKVEFEGLSGDEFRFDGNGDGPARYNIIHFKQSQAGQYHWVKVGEY----TEG-E 842
            .:...:|.||.:|.|...:|:...||.:||..|||.:::::.|..|...:..:|.|    .|| |
Zfish   431 IQPWQVLYYLTQVNFTTKNGENVHFDKHGDPVARYTLVNWQMSYEGIITFESIGLYDASKPEGQE 495

  Fly   843 LRL-NMTEVKFKRLSPKPPESVCSLPCLVGQAKKYVEGES-CCWHCFNCTTYQIRHPDDETHCKL 905
            ::: :..|..:.....|.|.||||..||.|..:.:|:|:. ||:.|.:|...:..:..:...|..
Zfish   496 IQMRDDIEAIWAGNQKKVPLSVCSETCLPGTRQAFVKGKPICCFDCIDCADGEFSNTTNAVTCIP 560

  Fly   906 CKLGTLPDAHKQYCRPIPEIYLRPESAWAIGAMAFSATGILVTLFVMGVFVRHNDTPIVRASGRE 970
            |.|....:.::..|......:|..........:.||..|..:|:.|..:|..|..||||||:..|
Zfish   561 CPLEYKSNGNRTQCVLKNIEFLTFNEVMGNILVTFSMCGGCLTITVGLIFFYHRHTPIVRANNSE 625

  Fly   971 LSYILLAGIFMCYGVTFALVLKPTNIVCAIQRFGVGFCFTVVYAALLTKTNRIARIFKAGKQSAK 1035
            ||::||..:.:|:..:...:.:||...|.::....|..|.:..:.:|.||..:...|:|....:.
Zfish   626 LSFLLLFSLTLCFLCSLTFIGQPTEWSCMLRHTAFGITFVLCISCVLGKTLVVLMAFRATLPGSN 690

  Fly  1036 RPSFISPKSQLVICACLVSVQILINGVWMVIAPSHAMHHYPTREDN------LLVCDSYIDASYM 1094
            ...:..|..|.:.......:|:||..:|:.::|.     :|.:..|      :|.|||.....:.
Zfish   691 VMKWFGPPQQRLSVFVFTFIQLLICMLWLTMSPP-----FPNKTTNNYKDKIILECDSGSAVGFW 750

  Fly  1095 IAFSYPIFLIVICTVYAVLTRKIPEAFNESKHIGFTMYTTCVIWLAFVPLYFGTANHVPLRITSM 1159
            ...||..||.::|.:.|.|.||:|:.|||:|.|.|:|...|.:|:.|:|.|..:.....:.:...
Zfish   751 AVLSYIGFLAILCFILAFLARKLPDNFNEAKFITFSMLIFCAVWITFIPAYISSPGKFTVAVEIF 815

  Fly  1160 SVTISLSASV-TIACLFSPKLYIILIRPERNVRQSMM 1195
            ::   |::|. .:.|:|.||.||||::|:.|.::.:|
Zfish   816 AI---LASSYGMLFCIFIPKCYIILLKPDLNSKKKIM 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mtt	NP_001260806.1	Periplasmic_Binding_Protein_Type_1	73..>152	CDD:299141
		PBP1_mGluR	393..847	CDD:107357	126/480 (26%)
		ANF_receptor	422..820	CDD:279440	110/407 (27%)
		NCD3G	861..910	CDD:284890	16/49 (33%)
		7tm_3	945..1181	CDD:278433	67/242 (28%)
olfcj1	NP_001103761.1	Periplasmic_Binding_Protein_Type_1	35..506	CDD:299141	128/500 (26%)
		ANF_receptor	78..471	CDD:279440	109/408 (27%)
		NCD3G	516..565	CDD:284890	16/48 (33%)
		7tm_3	601..835	CDD:278433	67/241 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910