Protein Alignment Mal-A8 and SLC3A1

DIOPT Version :10

• Sequence 1: NP_610384.1
• Gene: Mal-A8 / 35830
• FlyBaseID: FBgn0033297
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: NP_000332.2
• Gene: SLC3A1 / 6519
• HGNCID: 11025
• Length: 685
• Species: Homo sapiens
• Alignment Length: 606
• Identity: 211/606 - (34%)
• Similarity: 319/606 - (52%)
• Gaps: 68/606 - (11%)

  Fly     2 ELLSLLTL--LLLAIASNEACQVQSSSSETTKDWWQTAQFYQIYPRSFKDSDGDGIGDLNGITSK 64
            |:|..||:  :|:.||:..|.   .:.|....||||....|||||||||||:.||.|||.||..|
Human    87 EILFWLTVASVLVLIAATIAI---IALSPKCLDWWQEGPMYQIYPRSFKDSNKDGNGDLKGIQDK 148

  Fly    65 LEYLKDLGVTAAWLSPIFKSPMVDFGYDISDFFDIQPEYGTLEDFRTLIKRAKELDLKIVLDFVP 129
            |:|:..|.:...|::..:||.:.||.|.:.||.::.|.:||:|||..|:....:..||:::||:|
Human   149 LDYITALNIKTVWITSFYKSSLKDFRYGVEDFREVDPIFGTMEDFENLVAAIHDKGLKLIIDFIP 213

  Fly   130 NHSSNESEWFLKSVKREKGYEDYYVWHDGKVNSTTGKREPPTNWLQYFRGSAWEWNEVRQQYYLH 194
            ||:|::..||..|..|...|.|||:|||  .....||..||.|||..:..|:|.::|||.|.|.|
Human   214 NHTSDKHIWFQLSRTRTGKYTDYYIWHD--CTHENGKTIPPNNWLSVYGNSSWHFDEVRNQCYFH 276

  Fly   195 QFAVQQPDLNYRNPLVVEQMKRVLRYWLNEGVSGFRCDALPPLFEV------VPDSDGQFPDEVV 253
            ||..:|||||:|||.|.|::|.:||:||.:||.||..||:..|.|.      :..:..|.||.|
Human   277 QFMKEQPDLNFRNPDVQEEIKEILRFWLTKGVDGFSLDAVKFLLEAKHLRDEIQVNKTQIPDTV- 340

  Fly   254 SGATEDKEDRDYLTTTYIENQPETIDMVYQWRTVLDDHK------RIFGGNSSVLLIETYSPAWF 312
               |:..|.....|||.:...    |:|..:|..:|.:.      |..|..:....|:.
Human   341 ---TQYSELYHDFTTTQVGMH----DIVRSFRQTMDQYSTEPGRYRFMGTEAYAESIDR------ 392

  Fly   313 TMQFYGNRSTEGAHLPFNFNLITVMEQSGLSASNVQEAIDLWLKNMPAGRTPNWVLGNHDKRRAA 377
            |:.:||....:.|..||| |.:::::.  :|.::|.|.|..|::|||.|:.|||::|..|..|..
Human   393 TVMYYGLPFIQEADFPFN-NYLSMLDT--VSGNSVYEVITSWMENMPEGKWPNWMIGGPDSSRLT 454

  Fly   378 SRYGKENIDGMNMLVMILPGVSVTYQGEEIGMTDGEISWEDTVDPWGCNSNPNIYEQYTRDP--E 440
            ||.|.:.::.||||:..|||..:||.||||||  |.|            ...|:.|.|..:.  .
Human   455 SRLGNQYVNVMNMLLFTLPGTPITYYGEEIGM--GNI------------VAANLNESYDINTLRS 505

  Fly   441 RTPFQWTGGTNAGFTNGSSTWLPLAADYATINVEKELSDDHSHLKIYKALVALRKSSKTLQNG-- 503
            ::|.||...:||||:..|:||||..:||.|:||:.:.:...|.||:|:.|..|..:...|..|
Human   506 KSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWF 570

  Fly   504 -----STKYQALSEDIFVVQRSLTKSATIVLVINFGSVAKTVDLSQFDKSRTESLQLLIRSIDST 563
                 .:.|...:.::..:.|      ..::|:|||   ::..|:..:.......::.||...::
Human   571 CHLRNDSHYVVYTRELDGIDR------IFIVVLNFG---ESTLLNLHNMISGLPAKMRIRLSTNS 626

  Fly   564 KKEGTRYDPKALSLDPSEALV 584
            ..:|::.|...:.||..|.|:
Human   627 ADKGSKVDTSGIFLDKGEGLI 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A8	NP_610384.1	AmyAc_maltase	30..506	CDD:200467	187/496 (38%)
SLC3A1	NP_000332.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56
		AmyAc_SLC3A1	116..569	CDD:200494	186/485 (38%)