DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A8 and slc3a1

DIOPT Version :9

Sequence 1:	NP_610384.1	Gene:	Mal-A8 / 35830	FlyBaseID:	FBgn0033297	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	XP_021336428.1	Gene:	slc3a1 / 557757	ZFINID:	ZDB-GENE-090313-225	Length:	674	Species:	Danio rerio

Alignment Length:	580	Identity:	227/580 - (39%)
Similarity:	319/580 - (55%)	Gaps:	60/580 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSLLTLLLLAIASNEACQVQSSSSETTKDWWQTAQFYQIYPRSFKDSDGDGIGDLNGITSKLEYL 68
            |:|:.:....:|.:..|.          .|||.:..||:||||||||:.||:|||.||..||.:.
Zfish    88 LALIAMTAAIVALSPRCM----------SWWQLSPIYQVYPRSFKDSNADGVGDLRGIKEKLSHF 142

  Fly    69 KDLGVTAAWLSPIFKSPMVDFGYDISDFFDIQPEYGTLEDFRTLIKRAKELDLKIVLDFVPNHSS 133
            :.|.:.|.|:||.:||||.|||||:.||.|:.|.:||:|||..|:....:..||:::|::|||:|
Zfish   143 EYLNIKAIWISPFYKSPMRDFGYDVEDFRDVDPLFGTMEDFDDLLTSMHDKGLKLIMDYIPNHTS 207

  Fly   134 NESEWFLKSVKREKGYEDYYVWHDGKVNSTTGKREPPTNWLQYFRGSAWEWNEVRQQYYLHQFAV 198
            ::..||..|....:.|.|||:|    ||.|..|.  |.||:..|..|.||::|:|||.|.|||..
Zfish   208 DKHVWFQLSRNYTEPYTDYYIW----VNCTADKH--PNNWVSVFGNSTWEYDEIRQQCYFHQFLK 266

  Fly   199 QQPDLNYRNPLVVEQMKRVLRYWLNEGVSGFRCDALPPLFE---------VVPDSDGQFPDEVVS 254
            :|||||||||||:::|..::.:||.:||.|||.||:..:.|         |.||.|
Zfish   267 EQPDLNYRNPLVLQEMTDIIHFWLKKGVDGFRMDAVKHMLEATHLRDEPQVNPDQD--------- 322

  Fly   255 GATEDKEDRDYLTTTYIENQPETIDMVYQWRTVLDDHKRIFGGNSSVLLIETYSPAWF--TMQFY 317
            .:|.|.|...|...||  .|....:::..||..:|.:.| ..|....:::|:|.....  ||::|
Zfish   323 PSTVDTEFELYHDYTY--TQAGLHEILTDWRIQMDTYSR-EPGRYRFMVMESYDYEEIDKTMRYY 384

  Fly   318 GNRSTEGAHLPFNFNLITVMEQSGLSASNVQEAIDLWLKNMPAGRTPNWVLGNHDKRRAASRYGK 382
            |....:.:..||||.|:.:.:  .||.:..:..::.|:.|||.|:.||||:|||||.|..|..||
Zfish   385 GTNYAKESDFPFNFYLLDLPD--NLSGNYAKSIVERWMSNMPKGKWPNWVVGNHDKPRIGSSAGK 447

  Fly   383 ENIDGMNMLVMILPGVSVTYQGEEIGMTDGEISWEDTVDPWGCNSNPNIYEQY----TRDPERTP 443
            |.:..:|||::.|||...||.||||||.|..||  ...||.|         ||    :|||:|||
Zfish   448 EYVRALNMLLLTLPGTPTTYYGEEIGMVDVNIS--VIQDPAG---------QYDPSKSRDPQRTP 501

  Fly   444 FQWTGGTNAGFTNG-SSTWLPLAADYATINVEKELSDDHSHLKIYKALVALRKSSKTLQNGSTKY 507
            .||....||||:.. :.|||.:|:||.|:|||.:..|..|.:..|:||..||.|:..|..|...|
Zfish   502 MQWNNELNAGFSESLNGTWLDIASDYRTVNVEVQQDDTSSTISQYRALSLLRSSNVILSRGWFCY 566

  Fly   508 QALSEDIFVVQRSLT-KSATIVLVINFGSVAKTVDLSQFDKSRTESLQLLIRSIDSTKKE 566
            .....::|...|.|. .|...::|:|||. ..|.|||.. |...:||.|.:.:...|:.|
Zfish   567 VWNDVNVFAYLRELDGLSKGFLVVLNFGK-ETTTDLSSV-KELPDSLTLHLSTESITQTE 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A8	NP_610384.1	AmyAc_maltase	30..506	CDD:200467	204/491 (42%)
		trehalose_treC	33..585	CDD:274115	223/551 (40%)
		Malt_amylase_C	487..585	CDD:295440	27/81 (33%)
slc3a1	XP_021336428.1	SLC3A2_N	55..113	CDD:318284	7/34 (21%)
slc3a1	XP_021336428.1	AmyAc_SLC3A1	106..563	CDD:200494	203/487 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576507
Domainoid	1	1.000	311	1.000	Domainoid score	I1286
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
OMA	1	1.010	-	-		QHG53234
OrthoDB	1	1.010	-	-		D1384693at2759
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	O	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.810