DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A8 and amy2al2

DIOPT Version :9

Sequence 1:	NP_610384.1	Gene:	Mal-A8 / 35830	FlyBaseID:	FBgn0033297	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_001003729.1	Gene:	amy2al2 / 445049	ZFINID:	ZDB-GENE-040801-179	Length:	512	Species:	Danio rerio

Alignment Length:	564	Identity:	106/564 - (18%)
Similarity:	175/564 - (31%)	Gaps:	199/564 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELLSLLTLLLLAIASNEACQVQSSSSETTKDWWQTAQFYQIYPRSFKDSDGDGIGDLNGITSKL 65
            |.||.|:.:..|..|.:........:|......|:.|...:...|....:...|:    .|:...
Zfish     1 MMLLVLVAIFGLGFAQHNPNTKNGRTSIVHLFEWRWADIAEECERYLAPNGYGGV----QISPPS 61

  Fly    66 EYLKDLGVTAAW------LSPIFKSPMVDFGYDISDFFDIQPEYGTLEDFRTLIKRAKELDLKIV 124
            |::|   :|..|      ..||              .:::....||..:.:.:|.|...:.:.|.
Zfish    62 EHVK---LTNPWHPWWQRYQPI--------------SYNLCSRSGTEAELKDMITRCNNVGVNIY 109

  Fly   125 LDFVPNH-----------SSNESEWFLKSVKREKGYED-------YYVWHDGKVNSTTGKREPPT 171
            .|.|.||           ||..|.:       :...||       |..::|||..|.:|:.|
Zfish   110 ADVVINHMCKSIHGAGTPSSCGSHF-------DANKEDFPTVPYSYLDFNDGKCKSASGQIE--- 164

  Fly   172 NWLQYFRGSAWEWNEVRQQYYLHQFAVQQ-PDLNYRNPLVVEQMKRVLRYWLNEGVSGFRCDAL- 234
                       .:|::   |.:....::. .||......|..::...|...:..||:|||.||.
Zfish   165 -----------SYNDI---YQVRDCRLEDLLDLALEKDYVRGKVAEYLNKLIELGVAGFRVDACK 215

  Fly   235 ---------------------------PPLFEVVPDSDG---------------QFPDEVVSGAT 257
                                       |.:::.|.|..|               :|......|..
Zfish   216 HMWPGDLSNVYSRLKTLNTKWFPSGTKPFIYQEVIDLGGEPIKASEYYGLARVTEFKHSAKIGTA 280

  Fly   258 EDKEDRDYLTTTYIEN-------QPETIDMVYQWRTVLDDHKRIFG---GNSSVLLIETYSPAWF 312
            ..|.|.:.|  :|::|       .|....:|:     :|:|....|   |.:|||       .::
Zfish   281 VRKWDGEKL--SYLKNWGEGWGFMPSDKALVF-----VDNHDNQRGHGAGGASVL-------TFW 331

  Fly   313 TMQFYGNRSTEGAHLPFNFNLITVMEQSGLSASNVQEAIDLWLKNMPAGRTPN-WVLGNHDKRRA 376
            ..:.|  :...|..|...:.:..||       |:.|     |.:.:..|:..| |:
Zfish   332 DSRLY--KMAAGFMLAHPYGVTRVM-------SSYQ-----WDRKIVNGKDENDWM--------- 373

  Fly   377 ASRYGKENI-DGMNMLVMILPGVSVTYQGEEIGMTDGEISWEDTVDPWGCN------SNPNIYEQ 434
                |..:. ||....|.|.|           ..|.|        |.|.|.      .|..|:..
Zfish   374 ----GPPSFSDGSTKPVPINP-----------DSTCG--------DGWVCEHRWRQIRNMVIFRN 415

  Fly   435 YTRDPERTPFQW--TGGTNAGFTNGSSTWLPLAAD----YATIN 472
            ....  :..|.|  .|.:...|:.||..::.:..|    .||:|
Zfish   416 VVNG--QPLFNWWDNGNSQIAFSRGSKGFIVINNDNWELNATLN 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A8	NP_610384.1	AmyAc_maltase	30..506	CDD:200467	99/535 (19%)
		trehalose_treC	33..585	CDD:274115	99/532 (19%)
		Malt_amylase_C	487..585	CDD:295440
amy2al2	NP_001003729.1	AmyAc_bac_euk_AmyA	25..417	CDD:200456	90/496 (18%)
amy2al2	NP_001003729.1	Aamy_C	424..511	CDD:214749	9/34 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576519
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830