DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A8 and Mal-A5

DIOPT Version :9

Sequence 1:	NP_610384.1	Gene:	Mal-A8 / 35830	FlyBaseID:	FBgn0033297	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_610382.2	Gene:	Mal-A5 / 35828	FlyBaseID:	FBgn0050359	Length:	630	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	302/556 - (54%)
Similarity:	397/556 - (71%)	Gaps:	5/556 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 WWQTAQFYQIYPRSFKDSDGDGIGDLNGITSKLEYLKDLGVTAAWLSPIFKSPMVDFGYDISDFF 97
            |||||.||||||||||||:|||:||||||..:|.|||:||:||.||||||.|||.||||||::|.
  Fly    44 WWQTAAFYQIYPRSFKDSNGDGVGDLNGIAEQLPYLKELGITATWLSPIFTSPMADFGYDIANFT 108

  Fly    98 DIQPEYGTLEDFRTLIKRAKELDLKIVLDFVPNHSSNESEWFLKSVKREKGYEDYYVWHDGKVNS 162
            :|.|.:||:.||..|::.||:||:||:|||||||||:|.|||.:|..|:..::|:||||.|::.:
  Fly   109 EIAPIFGTMADFEHLMEVAKKLDIKIILDFVPNHSSDECEWFRRSAARDPEFKDFYVWHPGRMEN 173

  Fly   163 TTGKREPPTNWLQYFRGSAWEWNEVRQQYYLHQFAVQQPDLNYRNPLVVEQMKRVLRYWLNEGVS 227
              |.|.||:||:..||||||:|:|.||::|||||..:|||||||||.|.|.|..|||:||.:||:
  Fly   174 --GNRHPPSNWISVFRGSAWQWHEGRQEFYLHQFVKKQPDLNYRNPKVRETMSNVLRFWLGKGVA 236

  Fly   228 GFRCDALPPLFEVVPDSDGQFPDEVVSGATEDKEDRDYLTTTYIENQPETIDMVYQWRTVLDDHK 292
            |||.||:|.:||:.||:..|:.||..:....|.||..||...|.::||||||:||.||.|||.|:
  Fly   237 GFRIDAVPHVFEIAPDNQNQYRDEPRNDWDNDPEDYGYLQHIYTKDQPETIDLVYSWRAVLDAHQ 301

  Fly   293 RIFGGNSSVLLIETYSPAWFTMQFYGNRSTEGAHLPFNFNLITVMEQSGLSASNVQEAIDL-WLK 356
            |..||...:|:.|||||....||:|||.:.|||.|||||.||:  |.|..|.::..|...| ||:
  Fly   302 REHGGEDRILMAETYSPIDIVMQYYGNATAEGAQLPFNFLLIS--ELSNSSNAHAYEGTVLKWLQ 364

  Fly   357 NMPAGRTPNWVLGNHDKRRAASRYGKENIDGMNMLVMILPGVSVTYQGEEIGMTDGEISWEDTVD 421
            :||.|||.||||||||:.|..||.|::.:|.:|||...|||.||||||||:|||:..|||:||||
  Fly   365 HMPKGRTANWVLGNHDQPRVGSRLGRDRVDMLNMLTATLPGASVTYQGEELGMTNVWISWKDTVD 429

  Fly   422 PWGCNSNPNIYEQYTRDPERTPFQWTGGTNAGFTNGSSTWLPLAADYATINVEKELSDDHSHLKI 486
            |..||:||:|||||:|||||||||||...:|||:|.|.||||:|.||..:|||:|.....|||.:
  Fly   430 PSACNTNPSIYEQYSRDPERTPFQWTDAQDAGFSNASKTWLPIAVDYKEVNVEQERQKPLSHLNV 494

  Fly   487 YKALVALRKSSKTLQNGSTKYQALSEDIFVVQRSLTKSATIVLVINFGSVAKTVDLSQFDKSRTE 551
            :|.|..|||.|:||:.|.|:.:|||:.:..|:|.|.:.:|.:.::|.....:|::|.|.......
  Fly   495 FKQLWQLRKQSQTLKRGETEVKALSDAVLAVKRYLERDSTYLTLLNIYDGVETINLLQSFPDLPP 559

  Fly   552 SLQLLIRSIDSTKKEGTRYDPKALSLDPSEALVLTT 587
            .|::::.:..|..|.|...:..:|.|.|.::|||.|
  Fly   560 QLKVVVVTERSQVKVGDLVNSTSLQLQPKDSLVLQT 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A8	NP_610384.1	AmyAc_maltase	30..506	CDD:200467	279/473 (59%)
		trehalose_treC	33..585	CDD:274115	299/552 (54%)
		Malt_amylase_C	487..585	CDD:295440	29/97 (30%)
Mal-A5	NP_610382.2	AmyAc_maltase	41..514	CDD:200467	279/473 (59%)
Mal-A5	NP_610382.2	Alpha-amylase	67..421	CDD:278554	203/357 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443629
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	1	0.950	-	0.709012	Normalized mean entropy	S2995
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	13	12.750