DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A8 and Mal-A4

DIOPT Version :9

Sequence 1:	NP_610384.1	Gene:	Mal-A8 / 35830	FlyBaseID:	FBgn0033297	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_610381.1	Gene:	Mal-A4 / 35827	FlyBaseID:	FBgn0033294	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	583	Identity:	278/583 - (47%)
Similarity:	379/583 - (65%)	Gaps:	16/583 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLSLLTLLLLAIASNEACQVQSSSSETTKDWWQTAQFYQIYPRSFKDSDGDGIGDLNGITSKLEY 67
            |..||.|.|||:             :....||:||.||||||||||||||:|:|||||:|.||||
  Fly     7 LFLLLGLGLLAV-------------DAAAPWWKTASFYQIYPRSFKDSDGNGVGDLNGVTEKLEY 58

  Fly    68 LKDLGVTAAWLSPIFKSPMVDFGYDISDFFDIQPEYGTLEDFRTLIKRAKELDLKIVLDFVPNHS 132
            ||::||||.||||..||||.|||||||||..:.|.:||:|||..::.|||||.:||:||||||||
  Fly    59 LKEIGVTATWLSPFLKSPMADFGYDISDFKAVDPLFGTMEDFENMVSRAKELGVKIILDFVPNHS 123

  Fly   133 SNESEWFLKSVKREKGYEDYYVWHDGKVNSTTGKREPPTNWLQYFRGSAWEWNEVRQQYYLHQFA 197
            |:|.:|||:|...|:.|:|||:||.|.::. .|.|.|||||:..||||||||:|.||:||||||.
  Fly   124 SDECDWFLRSAAGEEEYKDYYMWHPGFLDE-DGTRRPPTNWVSVFRGSAWEWHEGRQEYYLHQFH 187

  Fly   198 VQQPDLNYRNPLVVEQMKRVLRYWLNEGVSGFRCDALPPLFEVVPDSDGQFPDEVVSGATEDKED 262
            .:|||.|:|||:|.|:|..|||:||.:||.|||.||:...||:..|.:|.:|||..:..|.|.::
  Fly   188 KKQPDFNFRNPVVREEMNNVLRFWLEKGVDGFRVDAIYHAFEIEADENGNYPDEPRNDWTNDPDE 252

  Fly   263 RDYLTTTYIENQPETIDMVYQWRTVLDDHKRIFGGNSSVLLIETYSPAWFTMQFYGNRSTEGAHL 327
            ..|....|..:||||..:||:||.:|:..:...||:..:|::||:||....|.:|||.:.:||.:
  Fly   253 YGYTHKIYTVDQPETPHLVYEWRQILEQFQADNGGDERILMVETWSPIEIVMHYYGNETADGAQI 317

  Fly   328 PFNFNLITVMEQSGLSASNVQEAIDLWLKNMPAGRTPNWVLGNHDKRRAASRYGKENIDGMNMLV 392
            ||||.||:.:.... .|.:.:..|:.||..||.|::.|||:|||||.|..||:|.:.:|..|:|:
  Fly   318 PFNFQLISNLHYDS-DAYHYEYLINNWLNLMPEGKSANWVIGNHDKNRVGSRFGADRVDLFNILL 381

  Fly   393 MILPGVSVTYQGEEIGMTDGEISWEDTVDPWGCNSNPNIYEQYTRDPERTPFQWTGGTNAGFTNG 457
            :.|||.|:||||||:||.||.:||||||||..||.....|...:|||.|||..|:..|.||||.|
  Fly   382 LTLPGCSITYQGEELGMLDGYVSWEDTVDPQACNGYEANYMDNSRDPARTPMHWSDETMAGFTTG 446

  Fly   458 SSTWLPLAADYATINVEKELSDDHSHLKIYKALVALRKSSKTLQNGSTKYQALSEDIFVVQRSLT 522
            :|||||::.||...||:.|.....|||.::|.|..||: ..:::.||.:.:|:|..:..|:|.|:
  Fly   447 NSTWLPVSTDYRQRNVKTERGVSLSHLNVFKRLQQLRQ-EPSIEEGSAEVKAVSNYVLAVKRHLS 510

  Fly   523 KSATIVLVINFGSVAKTVDLSQFDKSRTESLQLLIRSIDSTKKEGTRYDPKALSLDPSEALVL 585
            .....:.:.|.....:.|:||....|.....|..:.:..|.||.|.:....:::|.|.|::||
  Fly   511 GDFVYISLFNIFDSIENVNLSSVFGSLPAKFQYALVTEKSIKKVGDQVSAGSVTLMPHESIVL 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A8	NP_610384.1	AmyAc_maltase	30..506	CDD:200467	251/475 (53%)
		trehalose_treC	33..585	CDD:274115	269/551 (49%)
		Malt_amylase_C	487..585	CDD:295440	24/97 (25%)
Mal-A4	NP_610381.1	AmyAc_maltase	24..492	CDD:200467	249/470 (53%)
Mal-A4	NP_610381.1	Alpha-amylase	47..401	CDD:278554	187/355 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469238
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	1	0.950	-	0.709012	Normalized mean entropy	S2995
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	13	12.750