DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A8 and Mal-A2

DIOPT Version :9

Sequence 1:	NP_610384.1	Gene:	Mal-A8 / 35830	FlyBaseID:	FBgn0033297	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_476625.2	Gene:	Mal-A2 / 35825	FlyBaseID:	FBgn0002569	Length:	567	Species:	Drosophila melanogaster

Alignment Length:	590	Identity:	278/590 - (47%)
Similarity:	370/590 - (62%)	Gaps:	41/590 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSLLTLLLLAIASNEACQVQSSSSETTK--DWWQTAQFYQIYPRSFKDSDGDGIGDLNGITSKLE 66
            |.|..|||:           |::.|.|.  |||:.|..||||||||:||||||||||.||||:|.
  Fly     7 LGLAALLLI-----------STTQEGTADIDWWENASLYQIYPRSFQDSDGDGIGDLKGITSRLG 60

  Fly    67 YLKDLGVTAAWLSPIFKSPMVDFGYDISDFFDIQPEYGTLEDFRTLIKRAKELDLKIVLDFVPNH 131
            |||::|:||.||||||.|||.|||||||:|:||.|.:||||||..||..||.|.:||:|||||||
  Fly    61 YLKEIGITATWLSPIFTSPMSDFGYDISNFYDIDPIFGTLEDFDDLIVEAKSLGVKIILDFVPNH 125

  Fly   132 SSNESEWFLKSVKREKGYEDYYVWHDGKVNSTTGKREPPTNWLQYFRGSAWEWNEVRQQYYLHQF 196
            ||:|:.||.|||.||.||:|:|||.|||:|..||.|:||:||:..|.|..|.|||.||||:||||
  Fly   126 SSDENVWFEKSVNREDGYDDFYVWDDGKLNEETGARDPPSNWVSVFSGPMWTWNEKRQQYFLHQF 190

  Fly   197 AVQQPDLNYRNPLVVEQMKRVLRYWLNEGVSGFRCDALPPLFEVVPDSDGQFPDEVVSGATEDKE 261
            .|:|||||:.||:|.|.|..||::||:.||.|||.||:|.::| ..::||.:|||.|||...|..
  Fly   191 QVKQPDLNFTNPMVREHMLDVLKFWLDRGVDGFRIDAVPHIYE-HRNADGSYPDEPVSGWGSDPN 254

  Fly   262 DRDYLTTTYIENQPETIDMVYQWRTVLDDHKRIFGGNSSVLLIETYSPAWFTMQFYGNRSTEGAH 326
            ..||....|.::||.|:|::|:||..||:::...||:|.|||.|.||.......::||.:.:|..
  Fly   255 AYDYHDHIYTKDQPATVDLMYEWREFLDNYRAQNGGDSRVLLAEAYSSVETLSAYFGNSTHQGTQ 319

  Fly   327 LPFNFNLITVMEQSGLS-ASNVQEAIDLWLKNM-PAGRTPNWVLGNHDKRRAASRYGKENIDGMN 389
            ||.||.|   |..||.| |.:|..:||.|:..| ...:|.|||:||||..|.|.|.|...:|.:|
  Fly   320 LPMNFQL---MYLSGYSTAKDVVGSIDYWMNTMWKEHQTANWVVGNHDTNRVADRMGAHKVDLLN 381

  Fly   390 MLVMILPGVSVTYQGEEIGMTDGEISWEDTVDPWGCNSNPNIYEQYTRDPERTPFQWTGGTNAGF 454
            ::|..|||.||||.||||||::.::  |.|.|  .|..         ||.||||.|||.|.||.|
  Fly   382 VIVNALPGASVTYYGEEIGMSNVDV--ECTGD--SCED---------RDGERTPMQWTAGKNADF 433

  Fly   455 TNGSSTWLPLAADYATINVEKELSDDHSHLKIYKALVALRKSSKTL---QNGSTKYQALSEDIFV 516
            ::|.||||||:.:|...||:.|.....|.|.|:|.|..|:.||..|   ::|...|:|::|.:..
  Fly   434 SDGESTWLPLSPEYQRYNVQTERGVSRSSLNIFKGLQELKSSSAFLAFKEDGGFSYEAVTEQVLQ 498

  Fly   517 VQRSLTKSATIVLVINFGSVAKTVDLSQFDKSRTESLQLLIRSIDSTKKEGTRYD-PKALSLDPS 580
            :.|:...|....:::|.|:     .:...|....::.:.::.:..||...|.:.| .:.:.|.|.
  Fly   499 IIRTNKISEEYRILVNMGN-----GMEILDGLAPKTYEYVLATAYSTHYSGQKADLSQRIILMPY 558

  Fly   581 EALVL 585
            ||:||
  Fly   559 EAVVL 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A8	NP_610384.1	AmyAc_maltase	30..506	CDD:200467	253/482 (52%)
		trehalose_treC	33..585	CDD:274115	267/557 (48%)
		Malt_amylase_C	487..585	CDD:295440	23/101 (23%)
Mal-A2	NP_476625.2	AmyAc_maltase	24..484	CDD:200467	251/476 (53%)
Mal-A2	NP_476625.2	Alpha-amylase	50..405	CDD:278554	195/358 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469244
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	12	11.800