DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A8 and Mal-B2

DIOPT Version :9

Sequence 1:	NP_610384.1	Gene:	Mal-A8 / 35830	FlyBaseID:	FBgn0033297	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_001188791.2	Gene:	Mal-B2 / 34598	FlyBaseID:	FBgn0032382	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	589	Identity:	284/589 - (48%)
Similarity:	371/589 - (62%)	Gaps:	21/589 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLSLLTLLLLAIASNEACQVQSSSSETTKDWWQTAQFYQIYPRSFKDSDGDGIGDLNGITSKLEY 67
            |:.:|...||...|..|..|: |.:|...|||....||||||||||||:|||||||.||||||.|
  Fly     5 LIQILLFSLLNSGSIMAGLVK-SDTEDFIDWWPHTVFYQIYPRSFKDSNGDGIGDLKGITSKLRY 68

  Fly    68 LKDLGVTAAWLSPIFKSPMVDFGYDISDFFDIQPEYGTLEDFRTLIKRAKELDLKIVLDFVPNHS 132
            |.|.|:||.||||||:|||:||||||||:..|||||||::||..||..|.||.:|:|||||||||
  Fly    69 LADTGITATWLSPIFQSPMIDFGYDISDYKAIQPEYGTMQDFEELIDTAFELGIKVVLDFVPNHS 133

  Fly   133 SNESEWFLKSVKREKGYEDYYVWHDGKVNSTTGKREPPTNWLQYFRGSAWEWNEVRQQYYLHQFA 197
            |::.|||.||..||.||||:||||||.|.. .|.|.||.||...|.||||||:|.|:|||||||.
  Fly   134 SDQHEWFKKSAAREPGYEDFYVWHDGIVQE-NGTRVPPNNWPSVFYGSAWEWHEGREQYYLHQFT 197

  Fly   198 VQQPDLNYRNPLVVEQMKRVLRYWLNEGVSGFRCDALPPLFEVVPDSDGQFPDEVVSGATEDKED 262
            .:|||||||||.||:.|..||.:|||:||:|||.||:..|||     |....||.:||.|.|...
  Fly   198 KEQPDLNYRNPKVVQAMDDVLLFWLNKGVAGFRIDAVNHLFE-----DESLKDEPLSGKTTDSLS 257

  Fly   263 RDYLTTTYIENQPETIDMVYQWRTVLDDHKRIFGGN-----SSVLLIETYSPAWFTMQFY-GNRS 321
            .||....|..:.||.::|::.||.:|||    |...     :.:::.|.|:.......:| .:..
  Fly   258 YDYTKHIYSRDLPEVLEMIHHWRQLLDD----FSAKHPERPTRIMMTEAYAGLTQLADYYEDSNG 318

  Fly   322 TEGAHLPFNFNLITVMEQSGLSASNVQEAIDLWLKNMPAGRTPNWVLGNHDKRRAASRYGKENID 386
            ..|:||||||:.||.::... .|.:....::.||..||.|...|||:||||..|.|||:|..::|
  Fly   319 VRGSHLPFNFHFITDVKGDS-DARDYVYNVEKWLIYMPRGHAANWVMGNHDNPRVASRFGPASVD 382

  Fly   387 GMNMLVMILPGVSVTYQGEEIGMTD-GEISWEDTVDPWGCNSNPNIYEQYTRDPERTPFQWTGGT 450
            .||||::.||||:|||.|||:||.| .|:|||:||||...|....:|::.:|||.||||||...|
  Fly   383 AMNMLLLTLPGVAVTYNGEELGMVDYRELSWEETVDPPARNVGEKLYQEVSRDPVRTPFQWNNET 447

  Fly   451 NAGFTNGSSTWLPLAADYATINVEKELSDDHSHLKIYKALVALRKSSKTLQNGSTKYQALSEDIF 515
            ||||:..:.||||:..:|..:|:|.:...:.||.::||.|:.||||: .::.|....:.|:..:|
  Fly   448 NAGFSTAAKTWLPVHPNYLELNLEAQKVANRSHYQVYKDLLELRKSA-IMRVGRFNIEPLTRWVF 511

  Fly   516 VVQRSLTKSATIVLVINFGSVAKTVDLSQFDKSRTESLQLLIRSIDSTKKEGTRYDPKALSLDPS 580
            ..:||.....:|:.|||.....:.||||:| .|:.:.|.:.:..:||..:.|......||.|...
  Fly   512 AFKRSYPNFESIITVINVSDKEQLVDLSEF-LSQPKKLVVEVSGVDSKYQPGQSLAASALLLAAR 575

  Fly   581 EALV 584
            |.||
  Fly   576 EGLV 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A8	NP_610384.1	AmyAc_maltase	30..506	CDD:200467	251/482 (52%)
		trehalose_treC	33..585	CDD:274115	274/559 (49%)
		Malt_amylase_C	487..585	CDD:295440	32/98 (33%)
Mal-B2	NP_001188791.2	AmyAc_maltase	33..502	CDD:200467	251/480 (52%)
Mal-B2	NP_001188791.2	Malt_amylase_C	510..>541	CDD:351862	11/30 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469248
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	1	0.950	-	0.709012	Normalized mean entropy	S2995
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	11	10.850