DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A8 and Slc3a1

DIOPT Version :9

Sequence 1:	NP_610384.1	Gene:	Mal-A8 / 35830	FlyBaseID:	FBgn0033297	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_058912.1	Gene:	Slc3a1 / 29484	RGDID:	3709	Length:	683	Species:	Rattus norvegicus

Alignment Length:	603	Identity:	216/603 - (35%)
Similarity:	315/603 - (52%)	Gaps:	59/603 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ELLSLLTL--LLLAIASNEACQVQSSSSETTKDWWQTAQFYQIYPRSFKDSDGDGIGDLNGITSK 64
            |:|..||:  :.|.|.:..|..:   .|....||||....||||||||||||.||.|||.||..|
  Rat    84 EILFWLTVVSVFLLIGATIAIII---ISPKCLDWWQAGPMYQIYPRSFKDSDKDGNGDLKGIQEK 145

  Fly    65 LEYLKDLGVTAAWLSPIFKSPMVDFGYDISDFFDIQPEYGTLEDFRTLIKRAKELDLKIVLDFVP 129
            |:|:..|.:...|::..:|||:.||.|.:.||.:|.|.:||::||..|:....:..||:::||:|
  Rat   146 LDYITALNIKTIWITSFYKSPLKDFRYAVEDFKEIDPIFGTMKDFENLVAAVHDKGLKLIIDFIP 210

  Fly   130 NHSSNESEWFLKSVKREKGYEDYYVWHDGKVNSTTGKREPPTNWLQYFRGSAWEWNEVRQQYYLH 194
            ||:|::..||..|..|...|.|||:||:  .....|...||.|||..:..|:|:::|.|:|.|.|
  Rat   211 NHTSDKHPWFQSSRTRSGKYTDYYIWHN--CTHANGVTTPPNNWLSVYGNSSWQFDEERKQCYFH 273

  Fly   195 QFAVQQPDLNYRNPLVVEQMKRVLRYWLNEGVSGFRCDALPPLFEV------VPDSDGQFPDEVV 253
            ||..:|||||:|||.|.|::|.::::||::||.||..||:..|.|.      :..:..|.||.|
  Rat   274 QFLKEQPDLNFRNPAVQEEIKEIIKFWLSKGVDGFSFDAVKFLLEAKDLRNEIQVNTSQIPDTV- 337

  Fly   254 SGATEDKEDRDYLTTTYIENQPETIDMVYQWRTVLDDHK------RIFGGNSSVLLIETYSPAWF 312
               |...|.....|||.:...    |:|..:|..::...      |..|...|....|.
  Rat   338 ---TRYSELYHDFTTTQVGMH----DLVRDFRQTMNQFSREPGRYRFMGTEVSAESTER------ 389

  Fly   313 TMQFYGNRSTEGAHLPFNFNLITVMEQSGLSASNVQEAIDLWLKNMPAGRTPNWVLGNHDKRRAA 377
            ||.:||....:.|..|||..|.|:   ..||...|.|||..|::|||.|:.|||::|..:..|..
  Rat   390 TMVYYGLSFIQEADFPFNKYLATL---DTLSGHTVYEAITSWMENMPEGKWPNWMIGGPETSRLT 451

  Fly   378 SRYGKENIDGMNMLVMILPGVSVTYQGEEIGMTDGEISWEDTVDPWGCNSNPNIYEQYTRDP--E 440
            ||.|.|.::.||||:..|||..:||.||||||.|..|:              |:.|:|..:.  .
  Rat   452 SRVGSEYVNAMNMLLFTLPGTPITYYGEEIGMGDISIT--------------NLNERYDTNALLS 502

  Fly   441 RTPFQWTGGTNAGFTNGSSTWLPLAADYATINVEKELSDDHSHLKIYKALVALRKSSKTLQNGST 505
            ::|.||...:|||||..:.||||..:||.|:||:.:.:...|.|::|:.|..|......|..|
  Rat   503 KSPMQWDNSSNAGFTEANHTWLPTNSDYHTVNVDVQKTQPSSALRLYQDLSLLHARELLLSRG-- 565

  Fly   506 KYQALSED--IFVVQRSLTKSATIVLVI-NFGSVAKTVDLSQFDKSRTESLQLLIRSIDSTKKEG 567
            .:..|.:|  ..|..|.|.....:.||: |||..:..::|.:........|::.:.:..::|  |
  Rat   566 WFCLLRDDNHSVVYTRELDGIDKVFLVVLNFGESSTVLNLQETISDVPTKLRIRLSTNPASK--G 628

  Fly   568 TRYDPKALSLDPSEALVL 585
            :..|..|:||:..|.|:|
  Rat   629 SDVDTHAVSLEKGEGLIL 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A8	NP_610384.1	AmyAc_maltase	30..506	CDD:200467	187/489 (38%)
		trehalose_treC	33..585	CDD:274115	206/568 (36%)
		Malt_amylase_C	487..585	CDD:295440	25/100 (25%)
Slc3a1	NP_058912.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
Slc3a1	NP_058912.1	AmyAc_SLC3A1	113..566	CDD:200494	187/487 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337362
Domainoid	1	1.000	288	1.000	Domainoid score	I1508
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	379	1.000	Inparanoid score	I1996
OMA	1	1.010	-	-		QHG53234
OrthoDB	1	1.010	-	-		D1384693at2759
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		otm44438
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	O	PTHR10357
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X202
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.810