DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mal-A8 and GBE1

DIOPT Version :9

Sequence 1:	NP_610384.1	Gene:	Mal-A8 / 35830	FlyBaseID:	FBgn0033297	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_000149.4	Gene:	GBE1 / 2632	HGNCID:	4180	Length:	702	Species:	Homo sapiens

Alignment Length:	292	Identity:	63/292 - (21%)
Similarity:	102/292 - (34%)	Gaps:	85/292 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DW--WQTAQFYQI------YPRSFKDSDGD-GIGDLNGITSKLEY--------LKDLGVTAAWLS 79
            ||  |.....|:.      .|||.:..:.. ||....|..:..::        :|.||.....|.
Human   174 DWIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLM 238

  Fly    80 PIFK-SPMVDFGYDISDFFDIQPEYGTLEDFRTLIKRAKELDLKIVLDFVPNHSSNESEWFLKSV 143
            .|.: :....|||.|:.||.....|||.|:.:.|:..|..:.:.::||.|.:|:|..|   ...:
Human   239 AIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHASKNS---ADGL 300

  Fly   144 KREKGYEDYYVWHDGKVNSTTGKREPPTNW-LQYFRGSAWEWNEVRQQYYLHQFAVQQPDLNYRN 207
            ....|.:..| :|       :|.|.....| .:.|..|:||
Human   301 NMFDGTDSCY-FH-------SGPRGTHDLWDSRLFAYSSWE------------------------ 333

  Fly   208 PLVVEQMKRVLRYWLNE-GVSGFRCDALPPLFEVVPDSDGQFPDEVVSGATED-------KEDRD 264
              ::..:...:|:||.| ...|||.|.:..:.        .....|..|.:.|       :.|.|
Human   334 --ILRFLLSNIRWWLEEYRFDGFRFDGVTSML--------YHHHGVGQGFSGDYSEYFGLQVDED 388

  Fly   265 YLTTTYIENQ------PETIDMVYQWRTVLDD 290
            .||...:.|.      |::|       |:.:|
Human   389 ALTYLMLANHLVHTLCPDSI-------TIAED 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A8	NP_610384.1	AmyAc_maltase	30..506	CDD:200467	63/292 (22%)
		trehalose_treC	33..585	CDD:274115	62/291 (21%)
		Malt_amylase_C	487..585	CDD:295440
GBE1	NP_000149.4	PulA	2..699	CDD:330769	63/292 (22%)
		Substrate binding. /evidence=ECO:0000305\|PubMed:26199317, ECO:0007744\|PDB:5CLT, ECO:0007744\|PDB:5CLW	62..63
		Substrate binding. /evidence=ECO:0000305\|PubMed:26199317, ECO:0007744\|PDB:5CLT, ECO:0007744\|PDB:5CLW	91..93
		Substrate binding. /evidence=ECO:0000305\|PubMed:26199317, ECO:0007744\|PDB:5CLT, ECO:0007744\|PDB:5CLW	118..121
		Substrate binding. /evidence=ECO:0000305\|PubMed:26199317, ECO:0007744\|PDB:5CLT, ECO:0007744\|PDB:5CLW	333..336		1/28 (4%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000