DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A8 and Mal-A6

DIOPT Version :9

Sequence 1:	NP_610384.1	Gene:	Mal-A8 / 35830	FlyBaseID:	FBgn0033297	Length:	588	Species:	Drosophila melanogaster
Sequence 2:	NP_724679.2	Gene:	Mal-A6 / 246565	FlyBaseID:	FBgn0050360	Length:	601	Species:	Drosophila melanogaster

Alignment Length:	597	Identity:	343/597 - (57%)
Similarity:	440/597 - (73%)	Gaps:	19/597 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLSLLTLLLLAIASNEACQVQ------SSSSETTKDWWQTAQFYQIYPRSFKDSDGDGIGDLNGI 61
            |::.:.:|.:..|...|..|.      :::::||:||||.||||||||||:|||||||||||.||
  Fly     7 LIAAILVLGIHCALGSAAAVDLDLERATTAADTTRDWWQVAQFYQIYPRSYKDSDGDGIGDLQGI 71

  Fly    62 TSKLEYLKDLGVTAAWLSPIFKSPMVDFGYDISDFFDIQPEYGTLEDFRTLIKRAKELDLKIVLD 126
            .|||:|||::||||.|||||:.|||.|||||||||||||||||||.||..||..||:.::||:||
  Fly    72 ISKLDYLKEIGVTATWLSPIYSSPMADFGYDISDFFDIQPEYGTLADFDELIAEAKKRNIKIILD 136

  Fly   127 FVPNHSSNESEWFLKSVKREKGYEDYYVWHDGKVNSTTGKREPPTNWLQYFRGSAWEWNEVRQQY 191
            |||||||:|:.||.|||||||||||||:||||.||:||||||||:||||.|||||||||:.||||
  Fly   137 FVPNHSSDENVWFQKSVKREKGYEDYYMWHDGYVNATTGKREPPSNWLQAFRGSAWEWNDERQQY 201

  Fly   192 YLHQFAVQQPDLNYRNPLVVEQMKRVLRYWLNEGVSGFRCDALPPLFEVVPDSDGQFPDEVVSGA 256
            |||||||:|||||||||.||.||||||.|||:.||:|||.||:|..|||:||:||::|||.:||.
  Fly   202 YLHQFAVKQPDLNYRNPAVVAQMKRVLTYWLDRGVAGFRMDAVPWCFEVLPDADGRYPDEPLSGY 266

  Fly   257 TEDKEDRDYLTTTYIENQPETIDMVYQWRTVLDDHKRIFGGNSSVLLIETYSPAWFTMQFYGNRS 321
            |:|.:|..||...|.::..||::||:||||:|||::||.||::.|:::||||...:.|||||||:
  Fly   267 TDDPDDSSYLKHIYTQDLRETVEMVFQWRTLLDDYQRIHGGDTRVIMVETYSGLDYVMQFYGNRT 331

  Fly   322 TEGAHLPFNFNLIT----VMEQSGLSASNVQEAIDLWLKNMPAGRTPNWVLGNHDKRRAASRYGK 382
            |:||.:||||..|.    ....:.|:|:...:.|..||..||||:|.|||:||||:||..||||:
  Fly   332 TKGAQMPFNFQFIIGGNGDKNNTQLNATGFVKIISSWLSQMPAGQTANWVMGNHDQRRVGSRYGE 396

  Fly   383 ENIDGMNMLVMILPGVSVTYQGEEIGMTDGEISWEDTVDPWGCNSNPNIYEQYTRDPERTPFQWT 447
            ..||.||||.|.|||||:||||||:||||.:|||||:.||..||||.:||||:||||.||||||:
  Fly   397 NRIDLMNMLQMFLPGVSITYQGEELGMTDLDISWEDSRDPAACNSNSDIYEQFTRDPARTPFQWS 461

  Fly   448 GGTNAGFTNGSSTWLPLAADYATINVEKELSDDHSHLKIYKALVALRKSSKTLQNGSTKYQALSE 512
            ...||||:..::||||:..:|.|:|.:.|.|...|||.:||.||.||| |||||.|:|:|..:.:
  Fly   462 DEANAGFSTNATTWLPINPNYVTVNAKAENSTSPSHLSLYKQLVDLRK-SKTLQFGATRYANVGD 525

  Fly   513 DIFVVQRSLTKSATIVLVINFGSVAKTVDLSQFDKS----RTESLQLLIRSIDSTKKEGTRYDPK 573
            ::..::|.|:...:.|||.|   |..| .:|..|.:    .|.|.::.:.:..:....|......
  Fly   526 NVVAIRRYLSGEPSYVLVAN---VLDT-SVSGIDVASAIYATGSYKIKLLNPQAKATVGDSVTLS 586

  Fly   574 ALSLDPSEALVL 585
            .|:|:|..||:|
  Fly   587 NLTLEPYAALIL 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A8	NP_610384.1	AmyAc_maltase	30..506	CDD:200467	316/479 (66%)
		trehalose_treC	33..585	CDD:274115	334/559 (60%)
		Malt_amylase_C	487..585	CDD:295440	33/101 (33%)
Mal-A6	NP_724679.2	AmyAc_maltase	40..516	CDD:200467	315/476 (66%)
Mal-A6	NP_724679.2	trehalose_treC	43..599	CDD:274115	335/561 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469233
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	12	11.800