DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A7 and IMA4

DIOPT Version :9

Sequence 1:	NP_001286198.1	Gene:	Mal-A7 / 35829	FlyBaseID:	FBgn0033296	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_012314.1	Gene:	IMA4 / 853235	SGDID:	S000003757	Length:	589	Species:	Saccharomyces cerevisiae

Alignment Length:	598	Identity:	181/598 - (30%)
Similarity:	270/598 - (45%)	Gaps:	108/598 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AHPSWSCETTTSTTVTKDWWENAQFYQIYPRSFMDSDGDGIGDLNGITSKLEYLKDLGVTAAWLS 84
            |||    ||...      ||:.|..|||||.||.||:.||.||:.||.|||||:|:||..|.|:|
Yeast     6 AHP----ETEPK------WWKEATIYQIYPASFKDSNNDGWGDMKGIASKLEYIKELGTDAIWIS 60

  Fly    85 PIFTSPMVDFGYDISDFFDIQPEYGTLDDFRALIKRANELDLKIILDFVPNHSSDENSWFVKS-V 148
            |.:.||..|.||||:::..:.|.|||.:|..|||::.::|.:|.|.|.|.||.|.|:.||.:| .
Yeast    61 PFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRS 125

  Fly   149 NREKGYEDYYVWHDGRVNATTGGREPPSNWLQAFRGSAWEWNEKRQQYYLHQFAVQQADLNYRNP 213
            ::.....|::.|...:.....|...||:||...|.||||.::||.|::||..|...|.|||:.|
Yeast   126 SKTNPKRDWFFWRPPKGYDAEGKPIPPNNWRSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWEN- 189

  Fly   214 LVVEQMKRVL-----RYWLDLGVAGFRCDAVPVLFEIEPDADGQYADEELSGLTD----DVDDRK 269
               |..::.:     .||||.||.|||.| |..|:            .:::||.|    |.:.:.
Yeast   190 ---EDCRKAIYESAVGYWLDHGVDGFRID-VGSLY------------SKVAGLPDAPVIDENSKW 238

  Fly   270 YLKSDLIENRPETIDMAYQWRVVMDDY--QRIHGGETRVLLIETYAPPAYTMQFYGNRSTAGAHL 332
            .|......|.|.    .:::...|:.:  .|:..|...:.:.|.......|.:.|.:.|......
Yeast   239 QLSDPFTMNGPR----IHEFHQEMNKFIRNRVKDGREIMTVGEMRHATDETKRLYTSASRHELSE 299

  Fly   333 PFNFNLITVLASDGVSAGSIKTAVDNWLDNLP-----AGRTANW---VIGNHDQRRAASRYG--- 386
            .|||:...|..|.......|...:.:|...|.     ...|..|   .:.||||.|:.:|:|
Yeast   300 LFNFSHTDVGTSPKFRQNLIPYELKDWKVALAELFRYVNGTDCWSTIYLENHDQPRSITRFGDDS 364

  Fly   387 ----TANADAMNMLVMVLPGASVTYQGEELGMTDGEI---SW--EDTQDPAACNSNSDIYEQ--- 439
                ..:...:::|::.|.|....|||:||    |||   :|  |..:|....|:...|.|:
Yeast   365 PKNRVISGKLLSVLLVSLSGTLYVYQGQEL----GEINFKNWPIEKYEDVEVRNNYDAIKEEHGE 425

  Fly   440 --------------FTRDPSRTPFQWT-NGTNAGFS-TASKTWLPLAADY-QTLNVETEAAAQRS 487
                          .:||.:|||.||: ...||||| ..:|.|..|...: :.:|.|.|:....|
Yeast   426 NSKEMKRFLEAIALISRDHARTPMQWSREEPNAGFSGPNAKPWFYLNESFREGINAEDESKDPNS 490

  Fly   488 HLKIYKALVELRKSSLPLQNGSTKYGVVGENVFV--------VKRYISGSASIIYVANFASKGVT 544
            .|..:|..:..||:...:    |.||...|.:.:        .|:|  .:.::....||:|..:
Yeast   491 VLNFWKEALRFRKAHKDI----TVYGYDFEFIDLDNKKLFSFTKKY--DNKTLFAALNFSSDSI- 548

  Fly   545 VDLYEFDKTLPTH 557
                  |.|:|.:
Yeast   549 ------DFTIPNN 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A7	NP_001286198.1	AmyAc_maltase	36..511	CDD:200467	164/526 (31%)
Mal-A7	NP_001286198.1	trehalose_treC	38..547	CDD:274115	173/568 (30%)
IMA4	NP_012314.1	AmyAc_SI_OligoGlu_DGase	16..503	CDD:200472	160/511 (31%)
IMA4	NP_012314.1	Malt_amylase_C	514..585	CDD:406946	9/51 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342166
Domainoid	1	1.000	192	1.000	Domainoid score	I624
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	257	1.000	Inparanoid score	I641
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm9159
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	O	PTHR10357
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R680
SonicParanoid	1	1.000	-	-		X202
TreeFam	0	0.000	Not matched by this tool.
	13	12.820