DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A7 and IMA5

DIOPT Version :9

Sequence 1:	NP_001286198.1	Gene:	Mal-A7 / 35829	FlyBaseID:	FBgn0033296	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_012319.1	Gene:	IMA5 / 853214	SGDID:	S000003752	Length:	581	Species:	Saccharomyces cerevisiae

Alignment Length:	517	Identity:	153/517 - (29%)
Similarity:	242/517 - (46%)	Gaps:	82/517 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 WWENAQFYQIYPRSFMDSDGDGIGDLNGITSKLEYLKDLGVTAAWLSPIFTSPMVDFGYDISDFF 102
            ||:.|..|||||.||.||:.||.|||.||||||:|:|:|||.|.|:.|.:.||..|.||||:::.
Yeast     9 WWKEATVYQIYPASFKDSNNDGWGDLAGITSKLDYVKELGVDAIWVCPFYDSPQEDMGYDIANYE 73

  Fly   103 DIQPEYGTLDDFRALIKRANELDLKIILDFVPNHSSDENSWFVKS-VNREKGYEDYYVWHDGRVN 166
            .:.|.|||.:|...:|:.|::..:|:|:|.|.||.|:|:.||.:| .::.....|::.|...:..
Yeast    74 KVWPRYGTNEDCFQMIEEAHKRGIKVIVDLVINHCSEEHEWFKESRSSKANPKRDWFFWRPPKGY 138

  Fly   167 ATTGGREPPSNWLQAFRGSAWEWNEKRQQYYLHQFAVQQADLNYRNPLVVEQMKRVL-----RYW 226
            ...|...||:||...|.||||.::||..:::||.||:.|.|.|:.|    |:.::.:     .||
Yeast   139 DEKGNPIPPNNWRSFFGGSAWRYDEKTGEFFLHVFALGQPDFNWEN----EECRKAIYDSSVGYW 199

  Fly   227 LDLGVAGFRCDAVPVLFEIE--PDADGQYADEELSGLTDDVDDRKYLK-SDLIENRPETIDMAYQ 288
            |...|.|||.|...:..::|  |||.          :||..  ..|.| ::...|.|.    .::
Yeast   200 LRHNVDGFRIDVGSMYSKVEGLPDAP----------ITDPT--VPYQKGTEFFINGPR----IHE 248

  Fly   289 WRVVMDDYQRIHGGETRVLL--------------IETYAPPA-YTMQFYGNRSTAGAHLPFNFNL 338
            :...|.:|......|.:.::              :.|.|... ..|.|....::.|.:....:.|
Yeast   249 YHKEMHNYMLSQVPEGKEIMTVGEVGIGNEDDFRVYTSAKEGELNMMFNFKHTSVGENPKCKYEL 313

  Fly   339 ITVLASDGVSAGSIKTAVDN---WLDNLPAGRTANWVIGNHDQRRAASRYGT-------ANADAM 393
            |.....|      .|.|:..   :::|.....|.  .:.||||.|:.||:|:       .::..:
Yeast   314 IPFTLKD------FKLALAESFLFIENTDCWSTI--YLENHDQPRSVSRFGSDSPKWREISSKML 370

  Fly   394 NMLVMVLPGASVTYQGEELGM------------------TDGEISWEDTQDPAACNSNSDIYEQF 440
            ..|::.|.|....|||:||||                  |...|..:..:|........:.....
Yeast   371 ATLIISLTGTVFIYQGQELGMPNFKNRKIEQIKCVEGTGTYAAIKRDYGEDSEKMKKFFEALALI 435

  Fly   441 TRDPSRTPFQWT-NGTNAGFSTASKTWLPLAADYQT-LNVETEAAAQRSHLKIYKALVELRK 500
            :||..||||.|: :..:||||..:|.|:.:...::. :|.|.|...:.|....:|..:::||
Yeast   436 SRDHGRTPFPWSADEPSAGFSKDAKPWIDMNESFRDGINAEAELKDKNSVFFFWKKALQVRK 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A7	NP_001286198.1	AmyAc_maltase	36..511	CDD:200467	153/517 (30%)
Mal-A7	NP_001286198.1	trehalose_treC	38..547	CDD:274115	153/517 (30%)
IMA5	NP_012319.1	AmyAc_SI_OligoGlu_DGase	11..498	CDD:200472	151/515 (29%)
IMA5	NP_012319.1	Malt_amylase_C	509..>548	CDD:413446
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342172
Domainoid	1	1.000	192	1.000	Domainoid score	I624
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	257	1.000	Inparanoid score	I641
Isobase	1	0.950	-	0.712175	Normalized mean entropy	S6632
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm9159
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	O	PTHR10357
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R680
SonicParanoid	1	1.000	-	-		X202
TreeFam	0	0.000	Not matched by this tool.
	14	13.770