DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A7 and MAL32

DIOPT Version :9

Sequence 1:	NP_001286198.1	Gene:	Mal-A7 / 35829	FlyBaseID:	FBgn0033296	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_009858.3	Gene:	MAL32 / 852602	SGDID:	S000000503	Length:	584	Species:	Saccharomyces cerevisiae

Alignment Length:	554	Identity:	166/554 - (29%)
Similarity:	241/554 - (43%)	Gaps:	123/554 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LVILAHPSWSCETTTSTTVTKDWWENAQFYQIYPRSFMDSDGDGIGDLNGITSKLEYLKDLGVTA 80
            :.|..||    ||...      ||:.|..|||||.||.||:.||.|||.||||||:|:|||||.|
Yeast     1 MTISDHP----ETEPK------WWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDA 55

  Fly    81 AWLSPIFTSPMVDFGYDISDFFDIQPEYGTLDDFRALIKRANELDLKIILDFVPNHSSDENSWFV 145
            .|:.|.:.||..|.|||||::..:.|.|||.:|...||.:.::|.:|.|.|.|.||.|.|:.||.
Yeast    56 IWVCPFYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFK 120

  Fly   146 KS-VNREKGYEDYYVWHDGRVNATTGGREPPSNWLQAFRGSAWEWNEKRQQYYLHQFAVQQADLN 209
            :| .::.....|::.|...:.....|...||:||...|.||||.::|...::||..||.:|.|||
Yeast   121 ESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASRQVDLN 185

  Fly   210 YRNPLVVEQMKRVL-----RYWLDLGVAGFRCDAVPVLFEIEPDADGQYADEELSGLTDD-VDDR 268
            :.|    |..:|.:     .:|||.||.|||.|..           |.|:  :..||.|. :.|:
Yeast   186 WEN----EDCRRAIFESAVGFWLDHGVDGFRIDTA-----------GLYS--KRPGLPDSPIFDK 233

  Fly   269 -------------------------KYLKSDLIENRPETIDMAYQWRVVMDDYQRIHGGETRVLL 308
                                     :::|:.:.:.|.           :|...:..||.:.  .|
Yeast   234 TSKLQHPNWGSHNGPRIHEYHQELHRFMKNRVKDGRE-----------IMTVGEVAHGSDN--AL 285

  Fly   309 IETYAPPAYTMQFYGNRSTAGAHLPFNFNLI--------TVLASDGVSAGSIKTAVDNWLDNLPA 365
            ..:.|....:..|.......|....|.:|::        ..:||:.:    .....|:|
Yeast   286 YTSAARYEVSEVFSFTHVELGTSPFFRYNIVPFTLKQWKEAIASNFL----FINGTDSW------ 340

  Fly   366 GRTANWVIGNHDQRRAASR-------YGTANADAMNMLVMVLPGASVTYQGEELGMTDGEISW-- 421
               |...|.||||.|:.:|       |...:...:.:|...|.|....|||:|:|..:.: .|
Yeast   341 ---ATTYIENHDQARSITRFADDSPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFK-EWPI 401

  Fly   422 EDTQDPAACNSNSDIYEQF-----------------TRDPSRTPFQWT-NGTNAGFSTAS-KTWL 467
            |..:|....|:...|.:.|                 :||.||||..|| :..||||:... |.|.
Yeast   402 EKYEDVDVKNNYEIIKKSFGKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWF 466

  Fly   468 PLAADY-QTLNVETEAAAQRSHLKIYKALVELRK 500
            .|...: |.:|||.|:....|.|..:|..::.||
Yeast   467 FLNESFEQGINVEQESRDDDSVLNFWKRALQARK 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A7	NP_001286198.1	AmyAc_maltase	36..511	CDD:200467	161/534 (30%)
Mal-A7	NP_001286198.1	trehalose_treC	38..547	CDD:274115	161/532 (30%)
MAL32	NP_009858.3	AmyAc_SI_OligoGlu_DGase	15..501	CDD:200472	159/530 (30%)
MAL32	NP_009858.3	Malt_amylase_C	511..583	CDD:406946
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342171
Domainoid	1	1.000	192	1.000	Domainoid score	I624
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	257	1.000	Inparanoid score	I641
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm9159
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	O	PTHR10357
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R680
SonicParanoid	1	1.000	-	-		X202
TreeFam	0	0.000	Not matched by this tool.
	13	12.820