DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A7 and slc3a1

DIOPT Version :9

Sequence 1:	NP_001286198.1	Gene:	Mal-A7 / 35829	FlyBaseID:	FBgn0033296	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_001072903.1	Gene:	slc3a1 / 780365	XenbaseID:	XB-GENE-999160	Length:	693	Species:	Xenopus tropicalis

Alignment Length:	561	Identity:	198/561 - (35%)
Similarity:	296/561 - (52%)	Gaps:	29/561 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DWWENAQFYQIYPRSFMDSDGDGIGDLNGITSKLEYLKDLGVTAAWLSPIFTSPMVDFGYDISDF 101
            |||:.:..||:||:||.||:.||.|||.|:..|:::...|.|...|::|.:.|.:.||.|.:.|.
Frog   118 DWWQRSPIYQVYPKSFKDSNNDGSGDLKGVQEKIDHFIYLDVKNIWVAPFYKSSLKDFNYAVDDH 182

  Fly   102 FDIQPEYGTLDDFRALIKRANELDLKIILDFVPNHSSDENSWFVKSVNREKGYEDYYVWHDGRVN 166
            .::.|.:||:.||.::|...::..||:|:|.:|||:|:::.||..|.||...|.|||:|||   .
Frog   183 MEVDPTFGTMADFDSMISAMHDKGLKLIIDLIPNHTSNKHKWFQLSRNRTDKYTDYYIWHD---C 244

  Fly   167 ATTGG-REPPSNWLQAFRGSAWEWNEKRQQYYLHQFAVQQADLNYRNPLVVEQMKRVLRYWLDLG 230
            |..|| |.||:||:..:..||||::..|.|.|||||..:|.|||:.||.|.|::..::::||..|
Frog   245 AQVGGVRVPPNNWVSVYGDSAWEYDVTRNQCYLHQFRKEQPDLNFNNPDVHEEILNIIKFWLGKG 309

  Fly   231 VAGFRCDAVPVLFEIEPDADGQYADE-ELSGLTDDVDDRKY--LKSDLIENRPETIDMAYQWRVV 292
            |.||..::...:.|.|     .:.|| :::.|.|......|  |..|....:....|:...:|..
Frog   310 VDGFTINSAKFILEAE-----HFRDEPQVNKLQDPATISNYAELFHDYTTTQVGMHDIIRNFRQT 369

  Fly   293 MDDYQRIHGGETRVLLIETYAPPAY--TMQFYGNRSTAGAHLPFNFNLITVLASDGVSAGSIKTA 355
            ::.|.| ..|..|.:..|:...||.  ||.:|||.....|..|.|..|:. |:...::..||.:.
Frog   370 INKYSR-EPGRYRFMGTESNDQPAIDKTMLYYGNSFIQEADFPLNSYLLD-LSRTNLNGLSIFSN 432

  Fly   356 VDNWLDNLPAGRTANWVIGNHDQRRAASRYGTANADAMNMLVMVLPGASVTYQGEELGMTDGEIS 420
            ||.|:.::|:|:..:|::|.....|.:||.|....:.||||::.|||...||.||||||.||..:
Frog   433 VDLWMKSMPSGKWPSWMVGGPSYSRISSRVGRQYINVMNMLLLTLPGTPTTYYGEELGMEDGSPN 497

  Fly   421 WEDTQDPAACNSNSDIYEQFTRDPSRTPFQWTNGTNAGFSTASKTWLPLAADYQTLNVETEAAAQ 485
             .||..|...|.        ...|.:||.||.:..|||||.|:||||.:..||:.:|||.:...|
Frog   498 -VDTDKPEEYNP--------VEYPEKTPMQWDSSENAGFSGANKTWLSINPDYEAVNVEAQKNEQ 553

  Fly   486 RSHLKIYKALVELRKSSLPLQNGSTKYGVVGENVFVVKRYISGSASI-IYVANFASKGVTVDLYE 549
            .|.|.:|:.|..||.:.|||..|...|.....|||...|.:.|...: :.|.||.... |:::.:
Frog   554 YSTLNLYRELNNLRNNELPLHRGWLCYTWSDLNVFAYVRELDGLNKVFMMVLNFGGAS-TINMRQ 617

  Fly   550 FDKTLPTHLTLLIRSLQSSKAEGSQFEVTGLSLAAGEALVL 590
            ....||....:.: |...|:. |.......:....||.|:|
Frog   618 EVPDLPAEAKIRL-STDGSRV-GKAVNTGSIETKPGEGLIL 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A7	NP_001286198.1	AmyAc_maltase	36..511	CDD:200467	179/479 (37%)
Mal-A7	NP_001286198.1	trehalose_treC	38..547	CDD:274115	188/515 (37%)
slc3a1	NP_001072903.1	AmyAc_SLC3A1	118..577	CDD:200494	178/477 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	269	1.000	Domainoid score	I1811
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1909
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1384693at2759
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		otm47485
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R680
SonicParanoid	1	1.000	-	-		X202
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.090