DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A7 and Mal-A8

DIOPT Version :9

Sequence 1:	NP_001286198.1	Gene:	Mal-A7 / 35829	FlyBaseID:	FBgn0033296	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_610384.1	Gene:	Mal-A8 / 35830	FlyBaseID:	FBgn0033297	Length:	588	Species:	Drosophila melanogaster

Alignment Length:	579	Identity:	418/579 - (72%)
Similarity:	485/579 - (83%)	Gaps:	2/579 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LVILAHPS-WSCET-TTSTTVTKDWWENAQFYQIYPRSFMDSDGDGIGDLNGITSKLEYLKDLGV 78
            |::||..| .:|:. ::|:..|||||:.|||||||||||.|||||||||||||||||||||||||
  Fly     9 LLLLAIASNEACQVQSSSSETTKDWWQTAQFYQIYPRSFKDSDGDGIGDLNGITSKLEYLKDLGV 73

  Fly    79 TAAWLSPIFTSPMVDFGYDISDFFDIQPEYGTLDDFRALIKRANELDLKIILDFVPNHSSDENSW 143
            |||||||||.|||||||||||||||||||||||:|||.|||||.||||||:|||||||||:|:.|
  Fly    74 TAAWLSPIFKSPMVDFGYDISDFFDIQPEYGTLEDFRTLIKRAKELDLKIVLDFVPNHSSNESEW 138

  Fly   144 FVKSVNREKGYEDYYVWHDGRVNATTGGREPPSNWLQAFRGSAWEWNEKRQQYYLHQFAVQQADL 208
            |:|||.||||||||||||||:||:|||.||||:||||.||||||||||.|||||||||||||.||
  Fly   139 FLKSVKREKGYEDYYVWHDGKVNSTTGKREPPTNWLQYFRGSAWEWNEVRQQYYLHQFAVQQPDL 203

  Fly   209 NYRNPLVVEQMKRVLRYWLDLGVAGFRCDAVPVLFEIEPDADGQYADEELSGLTDDVDDRKYLKS 273
            |||||||||||||||||||:.||:||||||:|.|||:.||:|||:.||.:||.|:|.:||.||.:
  Fly   204 NYRNPLVVEQMKRVLRYWLNEGVSGFRCDALPPLFEVVPDSDGQFPDEVVSGATEDKEDRDYLTT 268

  Fly   274 DLIENRPETIDMAYQWRVVMDDYQRIHGGETRVLLIETYAPPAYTMQFYGNRSTAGAHLPFNFNL 338
            ..|||:||||||.||||.|:||::||.||.:.|||||||:|..:||||||||||.||||||||||
  Fly   269 TYIENQPETIDMVYQWRTVLDDHKRIFGGNSSVLLIETYSPAWFTMQFYGNRSTEGAHLPFNFNL 333

  Fly   339 ITVLASDGVSAGSIKTAVDNWLDNLPAGRTANWVIGNHDQRRAASRYGTANADAMNMLVMVLPGA 403
            |||:...|:||.:::.|:|.||.|:|||||.|||:||||:||||||||..|.|.||||||:|||.
  Fly   334 ITVMEQSGLSASNVQEAIDLWLKNMPAGRTPNWVLGNHDKRRAASRYGKENIDGMNMLVMILPGV 398

  Fly   404 SVTYQGEELGMTDGEISWEDTQDPAACNSNSDIYEQFTRDPSRTPFQWTNGTNAGFSTASKTWLP 468
            ||||||||:||||||||||||.||..||||.:||||:||||.|||||||.||||||:..|.||||
  Fly   399 SVTYQGEEIGMTDGEISWEDTVDPWGCNSNPNIYEQYTRDPERTPFQWTGGTNAGFTNGSSTWLP 463

  Fly   469 LAADYQTLNVETEAAAQRSHLKIYKALVELRKSSLPLQNGSTKYGVVGENVFVVKRYISGSASII 533
            |||||.|:|||.|.:...||||||||||.|||||..||||||||..:.|::|||:|.::.||:|:
  Fly   464 LAADYATINVEKELSDDHSHLKIYKALVALRKSSKTLQNGSTKYQALSEDIFVVQRSLTKSATIV 528

  Fly   534 YVANFASKGVTVDLYEFDKTLPTHLTLLIRSLQSSKAEGSQFEVTGLSLAAGEALVLSS 592
            .|.||.|...||||.:|||:....|.|||||:.|:|.||::::...|||...|||||::
  Fly   529 LVINFGSVAKTVDLSQFDKSRTESLQLLIRSIDSTKKEGTRYDPKALSLDPSEALVLTT 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A7	NP_001286198.1	AmyAc_maltase	36..511	CDD:200467	371/474 (78%)
Mal-A7	NP_001286198.1	trehalose_treC	38..547	CDD:274115	386/508 (76%)
Mal-A8	NP_610384.1	AmyAc_maltase	30..506	CDD:200467	372/475 (78%)
		trehalose_treC	33..585	CDD:274115	407/551 (74%)
		Malt_amylase_C	487..585	CDD:295440	53/97 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469232
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	12	11.800