DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A7 and Mal-A4

DIOPT Version :9

Sequence 1:	NP_001286198.1	Gene:	Mal-A7 / 35829	FlyBaseID:	FBgn0033296	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_610381.1	Gene:	Mal-A4 / 35827	FlyBaseID:	FBgn0033294	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	585	Identity:	274/585 - (46%)
Similarity:	377/585 - (64%)	Gaps:	14/585 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LVCGLVILAHPSWSCETTTSTTVTKDWWENAQFYQIYPRSFMDSDGDGIGDLNGITSKLEYLKDL 76
            |:.||.:||           ......||:.|.|||||||||.||||:|:|||||:|.||||||::
  Fly     9 LLLGLGLLA-----------VDAAAPWWKTASFYQIYPRSFKDSDGNGVGDLNGVTEKLEYLKEI 62

  Fly    77 GVTAAWLSPIFTSPMVDFGYDISDFFDIQPEYGTLDDFRALIKRANELDLKIILDFVPNHSSDEN 141
            ||||.||||...|||.|||||||||..:.|.:||::||..::.||.||.:||||||||||||||.
  Fly    63 GVTATWLSPFLKSPMADFGYDISDFKAVDPLFGTMEDFENMVSRAKELGVKIILDFVPNHSSDEC 127

  Fly   142 SWFVKSVNREKGYEDYYVWHDGRVNATTGGREPPSNWLQAFRGSAWEWNEKRQQYYLHQFAVQQA 206
            .||::|...|:.|:|||:||.|.:: ..|.|.||:||:..||||||||:|.||:||||||..:|.
  Fly   128 DWFLRSAAGEEEYKDYYMWHPGFLD-EDGTRRPPTNWVSVFRGSAWEWHEGRQEYYLHQFHKKQP 191

  Fly   207 DLNYRNPLVVEQMKRVLRYWLDLGVAGFRCDAVPVLFEIEPDADGQYADEELSGLTDDVDDRKYL 271
            |.|:|||:|.|:|..|||:||:.||.|||.||:...||||.|.:|.|.||..:..|:|.|:..|.
  Fly   192 DFNFRNPVVREEMNNVLRFWLEKGVDGFRVDAIYHAFEIEADENGNYPDEPRNDWTNDPDEYGYT 256

  Fly   272 KSDLIENRPETIDMAYQWRVVMDDYQRIHGGETRVLLIETYAPPAYTMQFYGNRSTAGAHLPFNF 336
            ......::|||..:.|:||.:::.:|..:||:.|:|::||::|....|.:|||.:..||.:||||
  Fly   257 HKIYTVDQPETPHLVYEWRQILEQFQADNGGDERILMVETWSPIEIVMHYYGNETADGAQIPFNF 321

  Fly   337 NLITVLASDGVSAGSIKTAVDNWLDNLPAGRTANWVIGNHDQRRAASRYGTANADAMNMLVMVLP 401
            .||:.|..|. .|...:..::|||:.:|.|::|||||||||:.|..||:|....|..|:|::.||
  Fly   322 QLISNLHYDS-DAYHYEYLINNWLNLMPEGKSANWVIGNHDKNRVGSRFGADRVDLFNILLLTLP 385

  Fly   402 GASVTYQGEELGMTDGEISWEDTQDPAACNSNSDIYEQFTRDPSRTPFQWTNGTNAGFSTASKTW 466
            |.|:|||||||||.||.:|||||.||.|||.....|...:|||:|||..|::.|.|||:|.:.||
  Fly   386 GCSITYQGEELGMLDGYVSWEDTVDPQACNGYEANYMDNSRDPARTPMHWSDETMAGFTTGNSTW 450

  Fly   467 LPLAADYQTLNVETEAAAQRSHLKIYKALVELRKSSLPLQNGSTKYGVVGENVFVVKRYISGSAS 531
            ||::.||:..||:||.....|||.::|.|.:||:.. .::.||.:...|...|..|||::||...
  Fly   451 LPVSTDYRQRNVKTERGVSLSHLNVFKRLQQLRQEP-SIEEGSAEVKAVSNYVLAVKRHLSGDFV 514

  Fly   532 IIYVANFASKGVTVDLYEFDKTLPTHLTLLIRSLQSSKAEGSQFEVTGLSLAAGEALVLSSSSSS 596
            .|.:.|.......|:|.....:||......:.:.:|.|..|.|.....::|...|::||.|::::
  Fly   515 YISLFNIFDSIENVNLSSVFGSLPAKFQYALVTEKSIKKVGDQVSAGSVTLMPHESIVLRSTTTA 579

Fly 597 596
Fly 580 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A7	NP_001286198.1	AmyAc_maltase	36..511	CDD:200467	247/474 (52%)
Mal-A7	NP_001286198.1	trehalose_treC	38..547	CDD:274115	257/508 (51%)
Mal-A4	NP_610381.1	AmyAc_maltase	24..492	CDD:200467	245/470 (52%)
Mal-A4	NP_610381.1	Alpha-amylase	47..401	CDD:278554	186/355 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469240
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R680
SonicParanoid	1	1.000	-	-		X202
	13	12.830