DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A7 and Mal-A2

DIOPT Version :9

Sequence 1:	NP_001286198.1	Gene:	Mal-A7 / 35829	FlyBaseID:	FBgn0033296	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_476625.2	Gene:	Mal-A2 / 35825	FlyBaseID:	FBgn0002569	Length:	567	Species:	Drosophila melanogaster

Alignment Length:	594	Identity:	280/594 - (47%)
Similarity:	359/594 - (60%)	Gaps:	47/594 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 HFGLLVCGLVILAHPSWSCETTTSTTVTKDWWENAQFYQIYPRSFMDSDGDGIGDLNGITSKLEY 72
            |.||....|:         .||...|...||||||..||||||||.||||||||||.||||:|.|
  Fly     6 HLGLAALLLI---------STTQEGTADIDWWENASLYQIYPRSFQDSDGDGIGDLKGITSRLGY 61

  Fly    73 LKDLGVTAAWLSPIFTSPMVDFGYDISDFFDIQPEYGTLDDFRALIKRANELDLKIILDFVPNHS 137
            ||::|:||.||||||||||.|||||||:|:||.|.:|||:||..||..|..|.:|||||||||||
  Fly    62 LKEIGITATWLSPIFTSPMSDFGYDISNFYDIDPIFGTLEDFDDLIVEAKSLGVKIILDFVPNHS 126

  Fly   138 SDENSWFVKSVNREKGYEDYYVWHDGRVNATTGGREPPSNWLQAFRGSAWEWNEKRQQYYLHQFA 202
            ||||.||.||||||.||:|:|||.||::|..||.|:|||||:..|.|..|.||||||||:||||.
  Fly   127 SDENVWFEKSVNREDGYDDFYVWDDGKLNEETGARDPPSNWVSVFSGPMWTWNEKRQQYFLHQFQ 191

  Fly   203 VQQADLNYRNPLVVEQMKRVLRYWLDLGVAGFRCDAVPVLFEIEPDADGQYADEELSGLTDDVDD 267
            |:|.|||:.||:|.|.|..||::|||.||.|||.||||.::| ..:|||.|.||.:||...|.:.
  Fly   192 VKQPDLNFTNPMVREHMLDVLKFWLDRGVDGFRIDAVPHIYE-HRNADGSYPDEPVSGWGSDPNA 255

  Fly   268 RKYLKSDLIENRPETIDMAYQWRVVMDDYQRIHGGETRVLLIETYAPPAYTMQFYGNRSTAGAHL 332
            ..|......:::|.|:|:.|:||..:|:|:..:||::||||.|.|:.......::||.:..|..|
  Fly   256 YDYHDHIYTKDQPATVDLMYEWREFLDNYRAQNGGDSRVLLAEAYSSVETLSAYFGNSTHQGTQL 320

  Fly   333 PFNFNLITVLASDGVSAGSIKTAVDNWLDNL-PAGRTANWVIGNHDQRRAASRYGTANADAMNML 396
            |.||.|:.:  |...:|..:..::|.|::.: ...:|||||:||||..|.|.|.|....|.:|::
  Fly   321 PMNFQLMYL--SGYSTAKDVVGSIDYWMNTMWKEHQTANWVVGNHDTNRVADRMGAHKVDLLNVI 383

  Fly   397 VMVLPGASVTYQGEELGMTDGEISWEDTQDPAACNSNSDIYEQFTRDPSRTPFQWTNGTNAGFST 461
            |..||||||||.|||:||::.::  |.|.|  :|..         ||..|||.|||.|.||.||.
  Fly   384 VNALPGASVTYYGEEIGMSNVDV--ECTGD--SCED---------RDGERTPMQWTAGKNADFSD 435

  Fly   462 ASKTWLPLAADYQTLNVETEAAAQRSHLKIYKALVELRKSSLPL---QNGSTKYGVVGENVFVVK 523
            ...|||||:.:||..||:||....||.|.|:|.|.||:.||..|   ::|...|..|.|.|..:.
  Fly   436 GESTWLPLSPEYQRYNVQTERGVSRSSLNIFKGLQELKSSSAFLAFKEDGGFSYEAVTEQVLQII 500

  Fly   524 RYISGSASIIYVANFAS-----KGVTVDLYEF--DKTLPTHLTLLIRSLQSSKAEGSQFEVTGLS 581
            |....|.....:.|..:     .|:....||:  .....||.:       ..||:.||    .:.
  Fly   501 RTNKISEEYRILVNMGNGMEILDGLAPKTYEYVLATAYSTHYS-------GQKADLSQ----RII 554

  Fly   582 LAAGEALVL 590
            |...||:||
  Fly   555 LMPYEAVVL 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A7	NP_001286198.1	AmyAc_maltase	36..511	CDD:200467	252/478 (53%)
Mal-A7	NP_001286198.1	trehalose_treC	38..547	CDD:274115	259/517 (50%)
Mal-A2	NP_476625.2	AmyAc_maltase	24..484	CDD:200467	251/475 (53%)
Mal-A2	NP_476625.2	Alpha-amylase	50..405	CDD:278554	191/357 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469246
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	12	11.800