DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A7 and Mal-A1

DIOPT Version :9

Sequence 1:	NP_001286198.1	Gene:	Mal-A7 / 35829	FlyBaseID:	FBgn0033296	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_476627.3	Gene:	Mal-A1 / 35824	FlyBaseID:	FBgn0002570	Length:	577	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	284/545 - (52%)
Similarity:	371/545 - (68%)	Gaps:	6/545 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DWWENAQFYQIYPRSFMDSDGDGIGDLNGITSKLEYLKDLGVTAAWLSPIFTSPMVDFGYDISDF 101
            :|||:..:||||||||.||||||||||||:|.||:||||:|.|..||||||.|||||||||||||
  Fly    21 EWWESGNYYQIYPRSFRDSDGDGIGDLNGVTEKLQYLKDIGFTGTWLSPIFKSPMVDFGYDISDF 85

  Fly   102 FDIQPEYGTLDDFRALIKRANELDLKIILDFVPNHSSDENSWFVKSVNREKGYEDYYVWHDGRVN 166
            :.|.|||||::||..:|.:|.|:.:||||||||||||.||.||.|||:.:..|:|:|:||||::|
  Fly    86 YQIHPEYGTMEDFERMIAKAKEVGIKIILDFVPNHSSTENEWFTKSVDSDPVYKDFYIWHDGKIN 150

  Fly   167 ATTGGREPPSNWLQAFRGSAWEWNEKRQQYYLHQFAVQQADLNYRNPLVVEQMKRVLRYWLDLGV 231
            ..||.|||||||...||.|||||||.||||||||||:||||||||||.||.:||.|:|:||..||
  Fly   151 NETGEREPPSNWNSEFRYSAWEWNEVRQQYYLHQFAIQQADLNYRNPAVVNEMKNVIRFWLGKGV 215

  Fly   232 AGFRCDAVPVLFEIEPDADGQYADEELSGLT---DDVDDRKYLKSDLIENRPETIDMAYQWRVVM 293
            :|||.||||.|||::.|...||.||.|:..:   .|.||..|.:....::.||||||.||||.::
  Fly   216 SGFRIDAVPYLFEVDLDRYNQYPDEPLTNDSVNCPDPDDHCYTQHIYTQDMPETIDMVYQWRELV 280

  Fly   294 DDYQRIHGGETRVLLIETYAPPAYTMQFYGNRSTAGAHLPFNFNLITVLASDGVSAGSIKTAVDN 358
            |::...:||:.|:|:.|.|......|.:|||....|:|:||||:.:|.: ::...||.....:..
  Fly   281 DEFHVENGGDKRLLMTEAYTSFENIMTYYGNGVRNGSHIPFNFDFLTSI-NNASKAGEYVEHIKK 344

  Fly   359 WLDNLPAGRTANWVIGNHDQRRAASRYGTANADAMNMLVMVLPGASVTYQGEELGMTDGEISWED 423
            |:|.:|.|..||||:||||.:|.|||:|....|.:|:|:..|||.:|||.||||||||..|||||
  Fly   345 WMDAMPEGVYANWVLGNHDNKRVASRFGVQRTDLINILLQTLPGHAVTYNGEELGMTDVWISWED 409

  Fly   424 TQDPAACNSNSDIYEQFTRDPSRTPFQWTNGTNAGFSTASKTWLPLAADYQTLNVETEAAAQRSH 488
            |.||.||||:.|.|...:|||:|:|:||...:.|||::|..||||:|.||:|.|...:..|.|||
  Fly   410 TVDPNACNSDPDNYYARSRDPARSPYQWDASSKAGFTSADHTWLPVADDYKTNNALQQLRAPRSH 474

  Fly   489 LKIYKALVELRKSSLPLQNGSTKYGVVGENVFVVKRYISGSASIIYVANFASKGVTVDLYEFDKT 553
            |:|:|.||.:||.. ..:.|......:.::|.:..|..:||...:.|.|..|...|:||.::.:
  Fly   475 LQIFKKLVRVRKEP-SFRQGELNIQAIDDDVIIYSRQKTGSDLYVIVLNLGSTSKTLDLTKYYE- 537

  Fly   554 LPTHLTLLIRSLQSSKAEGSQFEVT 578
            |.|...::..||.|...:|...:.|
  Fly   538 LGTQAEVITTSLSSQYIDGDVIKST 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A7	NP_001286198.1	AmyAc_maltase	36..511	CDD:200467	267/476 (56%)
Mal-A7	NP_001286198.1	trehalose_treC	38..547	CDD:274115	275/511 (54%)
Mal-A1	NP_476627.3	AmyAc_maltase	21..496	CDD:200467	267/476 (56%)
Mal-A1	NP_476627.3	Alpha-amylase	45..404	CDD:278554	203/359 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	11	10.870