DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A7 and Mal-B1

DIOPT Version :9

Sequence 1:	NP_001286198.1	Gene:	Mal-A7 / 35829	FlyBaseID:	FBgn0033296	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_609522.1	Gene:	Mal-B1 / 34597	FlyBaseID:	FBgn0032381	Length:	584	Species:	Drosophila melanogaster

Alignment Length:	584	Identity:	282/584 - (48%)
Similarity:	382/584 - (65%)	Gaps:	18/584 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLVCGLV-ILAHPSWSCETTTSTTVTKDWWENAQFYQIYPRSFMDSDGDGIGDLNGITSKLEYLK 74
            :|..||| ||||...|.|....    .:||::..|||||||||.||:|||||||.||||:|:|.|
  Fly     9 ILSVGLVGILAHKHQSKELDAK----YNWWQHEVFYQIYPRSFQDSNGDGIGDLQGITSRLQYFK 69

  Fly    75 DLGVTAAWLSPIFTSPMVDFGYDISDFFDIQPEYGTLDDFRALIKRANELDLKIILDFVPNHSSD 139
            |.|:|:.|||||:.|||||||||||::.:||||||||:||.|||.:||||.:|:||||||||||:
  Fly    70 DTGITSVWLSPIYESPMVDFGYDISNYTNIQPEYGTLEDFDALIAKANELGVKVILDFVPNHSSN 134

  Fly   140 ENSWFVKSVNREKGYEDYYVWHDGRVNATTGGREPPSNWLQAFRGSAWEWNEKRQQYYLHQFAVQ 204
            ::.||:|||.||.||||:|||.|| :....|.|.||:|||..|.||||.||::||||||.||...
  Fly   135 KHPWFIKSVAREPGYEDFYVWEDG-ILLENGTRVPPNNWLSVFSGSAWMWNDERQQYYLRQFTYG 198

  Fly   205 QADLNYRNPLVVEQMKRVLRYWLDLGVAGFRCDAVPVLFEIEPDADGQYADEELSGLTDDVDDRK 269
            |.|||||||.|::.|..|:.:||:.|:||||.||:..::|     |.|..||..||.|||.::..
  Fly   199 QPDLNYRNPAVIKAMDDVMLFWLNKGIAGFRIDAIIYIYE-----DAQLRDEPPSGTTDDPNNEA 258

  Fly   270 YLKSDLIENRPETIDMAYQWRVVMDDYQRIHGGETRVLLIETYAPPAYTMQFY-GNRSTAGAHLP 333
            ||......|:||...:...||.::|:|...|.|..|:::.|.||..:..|::| .:....|...|
  Fly   259 YLSHIYTRNQPEDYGLLQHWRQLLDNYTANHDGPLRIMMTEGYASVSQLMEYYEDSNGVQGPQFP 323

  Fly   334 FNFNLITVLASDGVSAGSIKTAVDNWLDNLPAGRTANWVIGNHDQRRAASRYGTANADAMNMLVM 398
            |||:.||.|.::..:|..: ..:..||..:|.|..||||:||||..|.|||:|..:.||||||:|
  Fly   324 FNFDFITELNANSTAADFV-FYISRWLIYMPHGHVANWVMGNHDNPRVASRFGEKSVDAMNMLLM 387

  Fly   399 VLPGASVTYQGEELGMTD-GEISWEDTQDPAACNSNSDIYEQFTRDPSRTPFQWTNGTNAGFSTA 462
            .|||..:||.|||||||| .:|||.||.|..||.:..|.|:..:|||.|||.||::..|||||:|
  Fly   388 TLPGIGITYNGEELGMTDYRDISWSDTVDQPACEAGIDNYKTISRDPERTPMQWSSDVNAGFSSA 452

  Fly   463 SKTWLPLAADYQTLNVETEAAAQRSHLKIYKALVELRKSSLP-LQNGSTKYGVVGENVFVVKRYI 526
            .:||||:..:|:.||:..:..|:|||.|||::|::||:  || |:|||....||...||..||.:
  Fly   453 DRTWLPVNPNYKELNLRNQQQARRSHYKIYQSLLKLRQ--LPVLKNGSFVPEVVNRRVFAFKREL 515

  Fly   527 SGSASIIYVANFASKGVTVDLYEFDKTLPTHLTLLIRSLQSSKAEGSQFEVTGLSLAAGEALVL 590
            ....:::.:.|.:::...||:.:|.:. |..|::|:..:.|....|.:.:...:.||..|.||:
  Fly   516 KNEHTLLTIVNVSNRTELVDIADFIEQ-PNRLSVLVAGVDSQHRVGDRLKAETIELAPNEGLVI 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A7	NP_001286198.1	AmyAc_maltase	36..511	CDD:200467	252/477 (53%)
Mal-A7	NP_001286198.1	trehalose_treC	38..547	CDD:274115	260/511 (51%)
Mal-B1	NP_609522.1	AmyAc_maltase	30..500	CDD:200467	252/482 (52%)
Mal-B1	NP_609522.1	trehalose_treC	33..538	CDD:274115	261/513 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469256
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	11	10.800