DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A7 and Slc3a1

DIOPT Version :9

Sequence 1:	NP_001286198.1	Gene:	Mal-A7 / 35829	FlyBaseID:	FBgn0033296	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_058912.1	Gene:	Slc3a1 / 29484	RGDID:	3709	Length:	683	Species:	Rattus norvegicus

Alignment Length:	569	Identity:	205/569 - (36%)
Similarity:	302/569 - (53%)	Gaps:	44/569 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DWWENAQFYQIYPRSFMDSDGDGIGDLNGITSKLEYLKDLGVTAAWLSPIFTSPMVDFGYDISDF 101
            |||:....||||||||.|||.||.|||.||..||:|:..|.:...|::..:.||:.||.|.:.||
  Rat   113 DWWQAGPMYQIYPRSFKDSDKDGNGDLKGIQEKLDYITALNIKTIWITSFYKSPLKDFRYAVEDF 177

  Fly   102 FDIQPEYGTLDDFRALIKRANELDLKIILDFVPNHSSDENSWFVKSVNREKGYEDYYVWHDGRVN 166
            .:|.|.:||:.||..|:...::..||:|:||:|||:||::.||..|..|...|.|||:||    |
  Rat   178 KEIDPIFGTMKDFENLVAAVHDKGLKLIIDFIPNHTSDKHPWFQSSRTRSGKYTDYYIWH----N 238

  Fly   167 AT--TGGREPPSNWLQAFRGSAWEWNEKRQQYYLHQFAVQQADLNYRNPLVVEQMKRVLRYWLDL 229
            .|  .|...||:|||..:..|:|:::|:|:|.|.|||..:|.|||:|||.|.|::|.::::||..
  Rat   239 CTHANGVTTPPNNWLSVYGNSSWQFDEERKQCYFHQFLKEQPDLNFRNPAVQEEIKEIIKFWLSK 303

  Fly   230 GVAGFRCDAVPVLFEIEPDADGQYADEELSGLTDDVDDRKYLKSDLIENRPETIDMAYQWRVVMD 294
            ||.||..|||..|.|.: |...: .....|.:.|.|.....|..|....:....|:...:|..|:
  Rat   304 GVDGFSFDAVKFLLEAK-DLRNE-IQVNTSQIPDTVTRYSELYHDFTTTQVGMHDLVRDFRQTMN 366

  Fly   295 DYQRIHGGETRVLLIETYAPPA-YTMQFYGNRSTAGAHLPFNFNLITVLASDGVSAGSIKTAVDN 358
            .:.| ..|..|.:..|..|... .||.:||......|..|||..|.|:   |.:|..::..|:.:
  Rat   367 QFSR-EPGRYRFMGTEVSAESTERTMVYYGLSFIQEADFPFNKYLATL---DTLSGHTVYEAITS 427

  Fly   359 WLDNLPAGRTANWVIGNHDQRRAASRYGTANADAMNMLVMVLPGASVTYQGEELGMTDGEISWED 423
            |::|:|.|:..||:||..:..|..||.|:...:|||||:..|||..:||.|||:||.|..|
  Rat   428 WMENMPEGKWPNWMIGGPETSRLTSRVGSEYVNAMNMLLFTLPGTPITYYGEEIGMGDISI---- 488

  Fly   424 TQDPAACNSNSDIYEQFTRDP--SRTPFQWTNGTNAGFSTASKTWLPLAADYQTLNVETEAAAQR 486
                      :::.|::..:.  |::|.||.|.:||||:.|:.||||..:||.|:||:.:.....
  Rat   489 ----------TNLNERYDTNALLSKSPMQWDNSSNAGFTEANHTWLPTNSDYHTVNVDVQKTQPS 543

  Fly   487 SHLKIYKALVELRKSSLPLQNG------STKYGVVGENVFVVKRYISGSASI-IYVANFASKGVT 544
            |.|::|:.|..|....|.|..|      ...:.|      |..|.:.|...: :.|.||......
  Rat   544 SALRLYQDLSLLHARELLLSRGWFCLLRDDNHSV------VYTRELDGIDKVFLVVLNFGESSTV 602

  Fly   545 VDLYEFDKTLPTHLTLLIRSLQSSKAEGSQFEVTGLSLAAGEALVLSSS 593
            ::|.|....:||.|.:.:.:..:||  ||..:...:||..||.|:|..|
  Rat   603 LNLQETISDVPTKLRIRLSTNPASK--GSDVDTHAVSLEKGEGLILEHS 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A7	NP_001286198.1	AmyAc_maltase	36..511	CDD:200467	182/484 (38%)
Mal-A7	NP_001286198.1	trehalose_treC	38..547	CDD:274115	188/520 (36%)
Slc3a1	NP_058912.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
Slc3a1	NP_058912.1	AmyAc_SLC3A1	113..566	CDD:200494	181/476 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337361
Domainoid	1	1.000	288	1.000	Domainoid score	I1508
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	379	1.000	Inparanoid score	I1996
OMA	1	1.010	-	-		QHG53234
OrthoDB	1	1.010	-	-		D1384693at2759
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		otm44438
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	O	PTHR10357
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X202
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.810