DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A7 and GBE1

DIOPT Version :9

Sequence 1:	NP_001286198.1	Gene:	Mal-A7 / 35829	FlyBaseID:	FBgn0033296	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_000149.4	Gene:	GBE1 / 2632	HGNCID:	4180	Length:	702	Species:	Homo sapiens

Alignment Length:	612	Identity:	119/612 - (19%)
Similarity:	197/612 - (32%)	Gaps:	200/612 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VTKDW--WENAQFYQI------YPRSFMDSDGD-GIGDLNGITSKLEY--------LKDLGVTAA 81
            |..||  |:....|:.      .|||....:.. ||....|..:..::        :|.||....
Human   171 VNYDWIHWDPEHSYEFKHSRPKKPRSLRIYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCI 235

  Fly    82 WLSPIFT-SPMVDFGYDISDFFDIQPEYGTLDDFRALIKRANELDLKIILDFVPNHSSDENSWFV 145
            .|..|.. :....|||.|:.||.....|||.::.:.|:..|:.:.:.::||.|.:|:| :||  .
Human   236 QLMAIMEHAYYASFGYQITSFFAASSRYGTPEELQELVDTAHSMGIIVLLDVVHSHAS-KNS--A 297

  Fly   146 KSVNREKGYEDYYVWHDGRVNATTGGREPPSNW-LQAFRGSAWEWNEKRQQYYLHQFAVQQADLN 209
            ..:|...|.:..| :|       :|.|.....| .:.|..|:||
Human   298 DGLNMFDGTDSCY-FH-------SGPRGTHDLWDSRLFAYSSWE--------------------- 333

  Fly   210 YRNPLVVEQMKRVLRYWL-DLGVAGFRCDAV-PVLFE---IEPDADGQYADEELSGLTDDVDDRK 269
                 ::..:...:|:|| :....|||.|.| .:|:.   :.....|.|:  |..||..|.|...
Human   334 -----ILRFLLSNIRWWLEEYRFDGFRFDGVTSMLYHHHGVGQGFSGDYS--EYFGLQVDEDALT 391

  Fly   270 YLKSDLIENRPETIDMAYQWRVVMDDYQRIHGGETRVLLIETYAPPAYTMQFYGNRSTAGAHLPF 334
            ||   ::.|.                            |:.|..|.:.|:.    ...:|  :|.
Human   392 YL---MLANH----------------------------LVHTLCPDSITIA----EDVSG--MPA 419

  Fly   335 NFNLITVLASDGVSAGSIKTAV---DNWLDNLPAGRTANWVIG--------------------NH 376
            ..:.|    |.|......:.|:   |.|:..|...:..:|.:|                    :|
Human   420 LCSPI----SQGGGGFDYRLAMAIPDKWIQLLKEFKDEDWNMGDIVYTLTNRRYLEKCIAYAESH 480

  Fly   377 DQRRAASR---YGTANADAMNMLVMVLPGASVTYQGEEL--------------------GMTDGE 418
            ||.....:   :...:|:....:.::.|...|..:|.:|                    |...|.
Human   481 DQALVGDKSLAFWLMDAEMYTNMSVLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGH 545

  Fly   419 ISWEDTQDPAACNSNSDIY--EQF-TRDPSRTPFQWTNGTNAGFSTASKTWLPLAADYQTLNVET 480
            ..|.|.  |...|:.|..|  .|| ..|.....:::.|..:...:...:.:..|||        .
Human   546 PEWLDF--PRKGNNESYHYARRQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAA--------P 600

  Fly   481 EAAAQRSHLKIYKALVELRKSSLPLQNGSTKYGVVGENVFVVKRYISGSASIIYVANF-ASKGVT 544
            :|.....|                          .|..:...:|     |.::::.|| .||..|
Human   601 QAYVSEKH--------------------------EGNKIIAFER-----AGLLFIFNFHPSKSYT 634

  Fly   545 VDLYEFDKTLPTHLTLLIRSLQSSKAE 571
            .  |.....||....::   |.|..||
Human   635 D--YRVGTALPGKFKIV---LDSDAAE 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A7	NP_001286198.1	AmyAc_maltase	36..511	CDD:200467	103/547 (19%)
Mal-A7	NP_001286198.1	trehalose_treC	38..547	CDD:274115	110/582 (19%)
GBE1	NP_000149.4	PulA	2..699	CDD:330769	119/612 (19%)
		Substrate binding. /evidence=ECO:0000305\|PubMed:26199317, ECO:0007744\|PDB:5CLT, ECO:0007744\|PDB:5CLW	62..63
		Substrate binding. /evidence=ECO:0000305\|PubMed:26199317, ECO:0007744\|PDB:5CLT, ECO:0007744\|PDB:5CLW	91..93
		Substrate binding. /evidence=ECO:0000305\|PubMed:26199317, ECO:0007744\|PDB:5CLT, ECO:0007744\|PDB:5CLW	118..121
		Substrate binding. /evidence=ECO:0000305\|PubMed:26199317, ECO:0007744\|PDB:5CLT, ECO:0007744\|PDB:5CLW	333..336		1/28 (4%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000