DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A7 and mal1

DIOPT Version :9

Sequence 1:	NP_001286198.1	Gene:	Mal-A7 / 35829	FlyBaseID:	FBgn0033296	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_595063.1	Gene:	mal1 / 2539976	PomBaseID:	SPBC1683.07	Length:	579	Species:	Schizosaccharomyces pombe

Alignment Length:	591	Identity:	176/591 - (29%)
Similarity:	267/591 - (45%)	Gaps:	110/591 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 STTVTKDWWENAQFYQIYPRSFMDSDGDGIGDLNGITSKLEYLKDLGVTAAWLSPIFTSPMVDFG 95
            |..:..:||.....|||||.||.||:|||.|||.||.||::|||.|.|.:.||.||:.||:.|.|
pombe     6 SEKIKPNWWRETSVYQIYPASFKDSNGDGFGDLEGIISKVDYLKALNVESIWLCPIYPSPLKDMG 70

  Fly    96 YDISDFFDIQPEYGTLDDFRALIKRANELDLKIILDFVPNHSSDENSWFVKS-VNREKGYEDYYV 159
            ||:||:..|...||||:|...|:|..:|.|:|:::|.|.||:||::.||.:| .::.....|:|.
pombe    71 YDVSDYKQIDSRYGTLEDLDRLMKALHERDMKLVMDLVLNHTSDQHEWFKESRSSKTNPKRDWYF 135

  Fly   160 WHDGRVNATTGGREPPSNWLQAFRGSAWEWNEKRQQYYLHQFAVQQADLNYRNPLVVEQMKRVLR 224
            |...|.| ..|.|.||:||...|..|||||:|..|:||||.::|.|.|||:..|.|.|.:..:||
pombe   136 WKPARYN-EKGERLPPNNWRSYFDTSAWEWDEATQEYYLHLWSVGQPDLNWETPKVREAVHDILR 199

  Fly   225 YWLDLGVAGFRCDAVPVLFEIEPDADGQYADEELSGLTDDVDDRKYLKSDLIENRPETIDMAYQW 289
            :|||.||.|||.||:.::.:                      |:::|.:.:.::|.| ..:|||:
pombe   200 FWLDRGVDGFRLDAINMISK----------------------DQRFLDAPITDDRYE-YQLAYQY 241

  Fly   290 -----RV---------VMDDYQRIHGGETRVLLIETYAPPAYTMQFYGNRSTAGAH-----LPFN 335
                 |:         ::.:|.....||.           .|.:.........||.     :.|.
pombe   242 YANGPRIHEYLNGIGNILTEYDAFSVGEM-----------PYVLDTNEILHVVGADRRELTMIFQ 295

  Fly   336 FNLITV--------LASDGVSAGSIKTAVDNWLDNLPAGRTANW---VIGNHDQRRAASR----- 384
            |:.:.:        ..........:|.::..|...|.:|  ..|   .|.||||.|..||
pombe   296 FDFVDLDLDPNQHKYIEGSWELSDLKKSLKKWQSALLSG--GGWNASFIENHDQTRTVSRYLSDS 358

  Fly   385 --YGTANADAMNMLVMVLPGASVTYQGEELGMTDGEISWE-------DTQ---------DPA--A 429
              |...::..|.:.::...|....:||:||.:.:....|.       :||         :|:  .
pombe   359 PKYRAYSSKLMALFIIFQSGTPFVFQGQELALANIPRDWPIDEYLDVETQNFWKLFMSGNPSQEE 423

  Fly   430 CNSNSDIYEQFTRDPSRTPFQWTNGTNAGFSTAS-KTWLPLAADYQTLNVETEAAAQRSHLKIYK 493
            .....||..:..||..|||..|.:..|.||:.|. |.|:.:..||:..|...:.....|....:.
pombe   424 IEKTMDIVNKRARDNGRTPMHWDSSPNGGFTKAGVKPWMRVTNDYKEWNAANQVNDPESPYTFWS 488

  Fly   494 ALVELRKSSLPLQNGSTKYG---VVGENVFVVKRYI--SGSASIIYVANFASKGVTVDLYEFDKT 553
            ..:||||.    ...:..||   ::.|....:..::  |.:..:|.:.||....|:.|
pombe   489 KALELRKE----LKDAVVYGSFELISEEDPSIVAFVRESSTYKLIILLNFTGNKVSYD------- 542

  Fly   554 LPTHLT 559
            .|.:||
pombe   543 CPLNLT 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A7	NP_001286198.1	AmyAc_maltase	36..511	CDD:200467	163/531 (31%)
Mal-A7	NP_001286198.1	trehalose_treC	38..547	CDD:274115	171/570 (30%)
mal1	NP_595063.1	trehalose_treC	13..579	CDD:274115	175/584 (30%)
		AmyAc_SI_OligoGlu_DGase	15..496	CDD:200472	160/517 (31%)
		Malt_amylase_C	504..576	CDD:295440	11/52 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	218	1.000	Domainoid score	I560
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	285	1.000	Inparanoid score	I649
OMA	1	1.010	-	-		QHG53234
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		otm46985
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	O	PTHR10357
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R680
SonicParanoid	1	1.000	-	-		X202
TreeFam	0	0.000	Not matched by this tool.
	13	12.900