Protein Alignment Mal-A5 and SLC3A2

DIOPT Version :10

• Sequence 1: NP_610382.2
• Gene: Mal-A5 / 35828
• FlyBaseID: FBgn0050359
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_001012680.1
• Gene: SLC3A2 / 6520
• HGNCID: 11026
• Length: 631
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 122/567 - (21%)
• Similarity: 211/567 - (37%)
• Gaps: 160/567 - (28%)

  Fly    43 KWWQTAAFYQIYPRSFKDSNGDGVGDLNGIAEQLPYLKELGITATWLSPIFTSPMADFGYDIANF 107
            |||.|.|.|:|  ...:...|.|.|:|.|:..:|.||..|.:....|.||..:...|...  .:.
Human   218 KWWHTGALYRI--GDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQ--TDL 278

  Fly   108 TEIAPIFGTMADFEHLMEVAKKLDIKIILDFVPNHSSDECEWFRRSAARDPEFKDFYVWHPGRME 172
            .:|.|.||:..||:.|::.|||..|::|||..||:                           |.|
Human   279 LQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNY---------------------------RGE 316

  Fly   173 NGNRHPPSNWISVFRGSAWQWHEGRQEFYLHQFVKKQPDLNYRNPKVRETMSNVLRFWLGKGVAG 237
            |       :|.|.                       |.|      .|...:.:.|.|||..||.|
Human   317 N-------SWFST-----------------------QVD------TVATKVKDALEFWLQAGVDG 345

  Fly   238 FRIDAVPHVFEIAPDNQNQYRDEPRNDWDNDPEDYGYLQHIYTKDQPETIDLVYSWRAVLDAHQR 302
            |::                      .|.:|..:...:|.               .|:.:....
Human   346 FQV----------------------RDIENLKDASSFLA---------------EWQNITKGF-- 371

  Fly   303 EHGGEDRILMAETYSPIDIVMQYYGNATAEGAQLPFNFLLISELSNSSNAHAYEGTVLKWLQHMP 367
               .|||:|:|.|.|.   .:|...:.......|   .|..|.||:|.:...:..:::....:..
Human   372 ---SEDRLLIAGTNSS---DLQQILSLLESNKDL---LLTSSYLSDSGSTGEHTKSLVTQYLNAT 427

  Fly   368 KGRTANWVLGNHDQPR-VGSRLGRDRVDMLNMLTATLPGASVTYQGEELGMTNVWISWKDTVDPS 431
            ..|..:|.|   .|.| :.|.|....:.:..::..||||..|...|:|:|:           |.:
Human   428 GNRWCSWSL---SQARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYGDEIGL-----------DAA 478

  Fly   432 ACNTNPSIYEQYSRDPERTPFQWTDAQDAGFSNASKTWLPIAVDYKEVNVEQERQKPLSHLNVFK 496
            |....|.         |.....|   .::.|.:     :|.||. ..:.|:.:.:.|.|.|::|:
Human   479 ALPGQPM---------EAPVMLW---DESSFPD-----IPGAVS-ANMTVKGQSEDPGSLLSLFR 525

  Fly   497 QLWQLRKQSQTLKRGETEVKALSDAVLAVKRYLERDSTYLTLLNIYD-----GVETINLLQSFPD 556
            :|...|.:.::|..|:....:....:.:..|:.:::..:|.:||..|     |::..:|..| ..
Human   526 RLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPAS-AS 589

  Fly   557 LPPQLKVVVVTERSQVKVGDLVNSTSLQLQPKDSLVLQTTSSYYSYA 603
            ||.:..:::.|:..: :.|..:....|:|:|.:.|:|:     :.||
Human   590 LPAKADLLLSTQPGR-EEGSPLELERLKLEPHEGLLLR-----FPYA 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A5	NP_610382.2	AmyAc_maltase	41..514	CDD:200467	103/471 (22%)
SLC3A2	NP_001012680.1	SLC3A2_N	161..226	CDD:464983	5/7 (71%)
		AmyAc_SLC3A2	208..537	CDD:200483	101/465 (22%)
		DUF3459	520..625	CDD:432205	22/106 (21%)