DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A2 and Mal-A1

DIOPT Version :9

Sequence 1:	NP_476625.2	Gene:	Mal-A2 / 35825	FlyBaseID:	FBgn0002569	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_476627.3	Gene:	Mal-A1 / 35824	FlyBaseID:	FBgn0002570	Length:	577	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	263/577 - (45%)
Similarity:	355/577 - (61%)	Gaps:	32/577 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AALLLISTTQEGTADIDWWENASLYQIYPRSFQDSDGDGIGDLKGITSRLGYLKEIGITATWLSP 74
            |.|||......|..  :|||:.:.||||||||:||||||||||.|:|.:|.|||:||.|.|||||
  Fly     7 ACLLLAIVGFVGAT--EWWESGNYYQIYPRSFRDSDGDGIGDLNGVTEKLQYLKDIGFTGTWLSP 69

  Fly    75 IFTSPMSDFGYDISNFYDIDPIFGTLEDFDDLIVEAKSLGVKIILDFVPNHSSDENVWFEKSVNR 139
            ||.|||.|||||||:||.|.|.:||:|||:.:|.:||.:|:||||||||||||.||.||.|||:.
  Fly    70 IFKSPMVDFGYDISDFYQIHPEYGTMEDFERMIAKAKEVGIKIILDFVPNHSSTENEWFTKSVDS 134

  Fly   140 EDGYDDFYVWDDGKLNEETGARDPPSNWVSVFSGPMWTWNEKRQQYFLHQFQVKQPDLNFTNPMV 204
            :..|.|||:|.|||:|.|||.|:|||||.|.|....|.|||.||||:||||.::|.|||:.||.|
  Fly   135 DPVYKDFYIWHDGKINNETGEREPPSNWNSEFRYSAWEWNEVRQQYYLHQFAIQQADLNYRNPAV 199

  Fly   205 REHMLDVLKFWLDRGVDGFRIDAVPHIYE-HRNADGSYPDEPVSGWG---SDPNAYDYHDHIYTK 265
            ...|.:|::|||.:||.||||||||:::| ..:....|||||::...   .||:.:.|..||||:
  Fly   200 VNEMKNVIRFWLGKGVSGFRIDAVPYLFEVDLDRYNQYPDEPLTNDSVNCPDPDDHCYTQHIYTQ 264

  Fly   266 DQPATVDLMYEWREFLDNYRAQNGGDSRVLLAEAYSSVETLSAYFGNSTHQGTQLPMNFQ-LMYL 329
            |.|.|:|::|:|||.:|.:..:||||.|:|:.|||:|.|.:..|:||....|:.:|.||. |..:
  Fly   265 DMPETIDMVYQWRELVDEFHVENGGDKRLLMTEAYTSFENIMTYYGNGVRNGSHIPFNFDFLTSI 329

  Fly   330 SGYSTAKDVVGSIDYWMNTMWKEHQTANWVVGNHDTNRVADRMGAHKVDLLNVIVNALPGASVTY 394
            :..|.|.:.|..|..||:.| .|...||||:||||..|||.|.|..:.||:|:::..|||.:|||
  Fly   330 NNASKAGEYVEHIKKWMDAM-PEGVYANWVLGNHDNKRVASRFGVQRTDLINILLQTLPGHAVTY 393

  Fly   395 YGEEIGMSNVDVE---------CTGDS----CEDRDGERTPMQWTAGKNADFSDGESTWLPLSPE 446
            .|||:||::|.:.         |..|.    ...||..|:|.||.|...|.|:..:.||||::.:
  Fly   394 NGEELGMTDVWISWEDTVDPNACNSDPDNYYARSRDPARSPYQWDASSKAGFTSADHTWLPVADD 458

  Fly   447 YQRYNVQTERGVSRSSLNIFKGLQELKSSSAFLAFKEDGGFSYEAVTEQVLQIIRTNKISEEYRI 511
            |:..|...:....||.|.|||.|..::...:|    ..|..:.:|:.:.|:...|....|:.|.|
  Fly   459 YKTNNALQQLRAPRSHLQIFKKLVRVRKEPSF----RQGELNIQAIDDDVIIYSRQKTGSDLYVI 519

  Fly   512 LVNMGNGMEILDGLAPKTYEY-----VLATAYSTHYSGQKADLSQRIILMPYEAVVL 563
            ::|:|:..:.||  ..|.||.     |:.|:.|:.|.......|...:..||...||
  Fly   520 VLNLGSTSKTLD--LTKYYELGTQAEVITTSLSSQYIDGDVIKSTEFVANPYVGTVL 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A2	NP_476625.2	AmyAc_maltase	24..484	CDD:200467	235/477 (49%)
Mal-A2	NP_476625.2	Alpha-amylase	50..405	CDD:278554	191/359 (53%)
Mal-A1	NP_476627.3	AmyAc_maltase	21..496	CDD:200467	236/479 (49%)
Mal-A1	NP_476627.3	Alpha-amylase	45..404	CDD:278554	191/359 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	11	10.870