Protein Alignment Mal-A2 and AMY2A

DIOPT Version :10

• Sequence 1: NP_476625.2
• Gene: Mal-A2 / 35825
• FlyBaseID: FBgn0002569
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_000690.1
• Gene: AMY2A / 279
• HGNCID: 477
• Length: 511
• Species: Homo sapiens
• Alignment Length: 426
• Identity: 85/426 - (19%)
• Similarity: 142/426 - (33%)
• Gaps: 148/426 - (34%)

  Fly    98 GTLEDFDDLIVEAKSLGVKIILDFVPNH----------SSDENVWFEKSVNREDGYDDFYV---- 148
            |..::|.:::....::||:|.:|.|.||          ||....:|      ..|..||..
Human    89 GNEDEFRNMVTRCNNVGVRIYVDAVINHMCGNAVSAGTSSTCGSYF------NPGSRDFPAVPYS 147

  Fly   149 -WD--DGKLNEETGARDPPSNWVSVFSGPMWTWNEKRQQYFLHQFQVKQ------PDLNFTNPMV 204
             ||  |||.  :||            ||.:..:|:..        ||:.      .||......|
Human   148 GWDFNDGKC--KTG------------SGDIENYNDAT--------QVRDCRLTGLLDLALEKDYV 190

  Fly   205 REHMLDVLKFWLDRGVDGFRIDAVPHIY-----------EHRNAD----GSYP--DEPVSGWGSD 252
            |..:.:.:...:|.||.|||:||..|::           .:.|::    ||.|  .:.|...|.:
Human   191 RSKIAEYMNHLIDIGVAGFRLDASKHMWPGDIKAILDKLHNLNSNWFPAGSKPFIYQEVIDLGGE 255

  Fly   253 P-NAYDYHDH--------------IYTKDQPATVDLMYEWRE------------FLDNYRAQNG- 289
            | .:.||..:              :..|.....:..:..|.|            |:||:..|.|
Human   256 PIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGFVPSDRALVFVDNHDNQRGH 320

  Fly   290 ----------GDSRV-------LLAEAYSSVETLSAY-------FGNSTHQGTQLPMNFQLMYLS 330
                      .|:|:       :||..|.....:|:|       .||..:.....|.|..:  :.
Human   321 GAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWPRQFQNGNDVNDWVGPPNNNGV--IK 383

  Fly   331 GYSTAKDVVGSIDYWMNTMWKEHQT-------------ANWVVGNHDTNRVADRMGAHKVDLLN- 381
            ..:...|.....|:.....|::.:.             .||.  ::.:|:||...|.....:.|
Human   384 EVTINPDTTCGNDWVCEHRWRQIRNMVIFRNVVDGQPFTNWY--DNGSNQVAFGRGNRGFIVFNN 446

  Fly   382 -------VIVNALPGASVTYYGEEIGMSNVDVECTG 410
                   .:...||..:   |.:.|....::..|||
Human   447 DDWSFSLTLQTGLPAGT---YCDVISGDKINGNCTG 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A2	NP_476625.2	AmyAc_maltase	24..484	CDD:200467	85/426 (20%)
AMY2A	NP_000690.1	AmyAc_bac_euk_AmyA	25..416	CDD:200456	71/356 (20%)
		Aamy_C	422..510	CDD:214749	14/63 (22%)