DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A1 and MAL12

DIOPT Version :9

Sequence 1:	NP_476627.3	Gene:	Mal-A1 / 35824	FlyBaseID:	FBgn0002570	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_011808.3	Gene:	MAL12 / 853209	SGDID:	S000003524	Length:	584	Species:	Saccharomyces cerevisiae

Alignment Length:	627	Identity:	177/627 - (28%)
Similarity:	270/627 - (43%)	Gaps:	132/627 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EWWESGNYYQIYPRSFRDSDGDGIGDLNGVTEKLQYLKDIGFTGTWLSPIFKSPMVDFGYDISDF 85
            :||:....|||||.||:||:.||.|||.|:|.||||:||:|....|:.|.:.||..|.|||||::
Yeast    12 KWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCPFYDSPQQDMGYDISNY 76

  Fly    86 YQIHPEYGTMEDFERMIAKAKEVGIKIILDFVPNHSSTENEWF--TKSVDSDPVYKDFYIWHDGK 148
            .::.|.|||.||...:|.|..::|:|.|.|.|.||.|||:|||  ::|..::| .:|::.|...|
Yeast    77 EKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFKESRSSKTNP-KRDWFFWRPPK 140

  Fly   149 INNETGEREPPSNWNSEFRYSAWEWNEVRQQYYLHQFAIQQADLNYRNP----AVVNEMKNVIRF 209
            ..:..|:..||:||.|.|..|||.::|...::||..||.:|.|||:.|.    |:   .::.:.|
Yeast   141 GYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASRQVDLNWENEDCRRAI---FESAVGF 202

  Fly   210 WLGKGVSGFRIDAVPYLFEVDLDRYNQ---YPDEPLTNDSVNCPDPDDHCYTQ---HIYTQDMPE 268
            ||..||.|||||..        ..|::   .||.|:.:.:.....|:...:..   |.|.|::..
Yeast   203 WLDHGVDGFRIDTA--------GLYSKRPGLPDSPIFDKTSKLQHPNWGSHNGPRIHEYHQELHR 259

  Fly   269 TI-DMVYQWRELVDEFHVENGGDKRLLMTEAYTSFENIMTYYGNGVRNGSHIPFNFDFLTSINNA 332
            .: :.|...||::....|.:|.|..|..:.|......:.::....|.......:|....|
Yeast   260 FMKNRVKDGREIMTVGEVAHGSDNALYTSAARYEVSEVFSFTHVEVGTSPFFRYNIVPFT----- 319

  Fly   333 SKAGEYVEHIKKWMDAMPEGV--------YANWVLGNHDNKRVASRFGVQRT-------DLINIL 382
                     :|:|.:|:....        :|...:.|||..|..:||.....       .|:.:|
Yeast   320 ---------LKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADDSPKYRKISGKLLTLL 375

  Fly   383 LQTLPGHAVTYNGEELGMTDV--W--ISWEDTVDPNACNSDPDNYY------------------- 424
            ..:|.|....|.|:|:|..:.  |  ..:||.        |..|.|
Yeast   376 ECSLTGTLYVYQGQEIGQINFKEWPIEKYEDV--------DVKNNYEIIKKSFGKNSKEMKDFFK 432

  Fly   425 ---ARSRDPARSPYQWDASS-KAGFTSAD-HTWLPVADDYKTN-NALQQLRAPRSHLQIFKKLVR 483
               ..|||.:|:|..|.... .||||..| ..|..:.:.::.. |..|:.|...|.|..:|:.::
Yeast   433 GIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFLLNESFEQGINVEQESRDDDSVLNFWKRALQ 497

  Fly   484 VRKEPSFRQGELNIQAIDDDVIIYSRQKTGSDLYVIVLNLGSTSKTLDLTKYYE-------LGTQ 541
            .||:..             :::||     |.|...|.|:   :.:....||.||       |...
Yeast   498 ARKKYK-------------ELMIY-----GYDFQFIDLD---SDQIFSFTKEYEDKTLFAALNFS 541

  Fly   542 AEVITTSLSSQ----------YIDGDVIKSTEFVANPYVGTV 573
            .|.|..||..:          |.|.||   :..|..|:.|.:
Yeast   542 GEEIEFSLPREGASLSFILGNYDDTDV---SSRVLKPWEGRI 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A1	NP_476627.3	AmyAc_maltase	21..496	CDD:200467	155/531 (29%)
Mal-A1	NP_476627.3	Alpha-amylase	45..404	CDD:278554	116/388 (30%)
MAL12	NP_011808.3	AmyAc_SI_OligoGlu_DGase	15..501	CDD:200472	152/519 (29%)
MAL12	NP_011808.3	Malt_amylase_C	511..583	CDD:406946	19/76 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	192	1.000	Domainoid score	I624
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	257	1.000	Inparanoid score	I641
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm9159
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	O	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
TreeFam	0	0.000	Not matched by this tool.
	11	10.860