DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A1 and SLC3A1

DIOPT Version :9

Sequence 1:	NP_476627.3	Gene:	Mal-A1 / 35824	FlyBaseID:	FBgn0002570	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_000332.2	Gene:	SLC3A1 / 6519	HGNCID:	11025	Length:	685	Species:	Homo sapiens

Alignment Length:	532	Identity:	201/532 - (37%)
Similarity:	298/532 - (56%)	Gaps:	33/532 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SAACLLLAIVGFVGAT----EWWESGNYYQIYPRSFRDSDGDGIGDLNGVTEKLQYLKDIGFTGT 65
            |...|:.|.:..:..:    :||:.|..||||||||:||:.||.|||.|:.:||.|:..:.....
Human    96 SVLVLIAATIAIIALSPKCLDWWQEGPMYQIYPRSFKDSNKDGNGDLKGIQDKLDYITALNIKTV 160

  Fly    66 WLSPIFKSPMVDFGYDISDFYQIHPEYGTMEDFERMIAKAKEVGIKIILDFVPNHSSTENEWFTK 130
            |::..:||.:.||.|.:.||.::.|.:|||||||.::|...:.|:|:|:||:|||:|.::.||..
Human   161 WITSFYKSSLKDFRYGVEDFREVDPIFGTMEDFENLVAAIHDKGLKLIIDFIPNHTSDKHIWFQL 225

  Fly   131 SVDSDPVYKDFYIWHDGKINNETGEREPPSNWNSEFRYSAWEWNEVRQQYYLHQFAIQQADLNYR 195
            |......|.|:|||||  ..:|.|:..||:||.|.:..|:|.::|||.|.|.|||..:|.|||:|
Human   226 SRTRTGKYTDYYIWHD--CTHENGKTIPPNNWLSVYGNSSWHFDEVRNQCYFHQFMKEQPDLNFR 288

  Fly   196 NPAVVNEMKNVIRFWLGKGVSGFRIDAVPYLFEVDLDRYNQYPDEPLTNDSVNCPDP-DDHCYTQ 259
            ||.|..|:|.::||||.|||.||.:|||.:|.|.     ....||...| ....||. ..:....
Human   289 NPDVQEEIKEILRFWLTKGVDGFSLDAVKFLLEA-----KHLRDEIQVN-KTQIPDTVTQYSELY 347

  Fly   260 HIYTQDMPETIDMVYQWRELVDEFHVENGGDKRLLMTEAYT-SFENIMTYYGNGVRNGSHIPFNF 323
            |.:|.......|:|..:|:.:|::..| .|..|.:.||||. |.:..:.|||......:..|||
Human   348 HDFTTTQVGMHDIVRSFRQTMDQYSTE-PGRYRFMGTEAYAESIDRTVMYYGLPFIQEADFPFN- 410

  Fly   324 DFLTSINNASKAGEYVEHIKKWMDAMPEGVYANWVLGNHDNKRVASRFGVQRTDLINILLQTLPG 388
            ::|:.::..|....| |.|..||:.||||.:.||::|..|:.|:.||.|.|..:::|:||.||||
Human   411 NYLSMLDTVSGNSVY-EVITSWMENMPEGKWPNWMIGGPDSSRLTSRLGNQYVNVMNMLLFTLPG 474

  Fly   389 HAVTYNGEELGMTD-VWISWEDTVDPNACNSDPDNYYARSRDPARSPYQWDASSKAGFTSADHTW 452
            ..:||.|||:||.: |..:..::.|.|...|             :||.|||.||.|||:.|.:||
Human   475 TPITYYGEEIGMGNIVAANLNESYDINTLRS-------------KSPMQWDNSSNAGFSEASNTW 526

  Fly   453 LPVADDYKTNNALQQLRAPRSHLQIFKKLVRVR-KEPSFRQGELNIQAIDDDVIIYSRQKTGSD- 515
            ||...||.|.|...|...|||.|::::.|..:. .|....:|.......|...::|:|:..|.|
Human   527 LPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGIDR 591

  Fly   516 LYVIVLNLGSTS 527
            ::::|||.|.::
Human   592 IFIVVLNFGEST 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A1	NP_476627.3	AmyAc_maltase	21..496	CDD:200467	189/478 (40%)
Mal-A1	NP_476627.3	Alpha-amylase	45..404	CDD:278554	143/361 (40%)
SLC3A1	NP_000332.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56
SLC3A1	NP_000332.2	AmyAc_SLC3A1	116..569	CDD:200494	188/476 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	287	1.000	Domainoid score	I1588
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2094
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53234
OrthoDB	1	1.010	-	-		D1384693at2759
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		otm40309
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	O	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.880