DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A1 and slc3a1

DIOPT Version :9

Sequence 1:	NP_476627.3	Gene:	Mal-A1 / 35824	FlyBaseID:	FBgn0002570	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	XP_021336428.1	Gene:	slc3a1 / 557757	ZFINID:	ZDB-GENE-090313-225	Length:	674	Species:	Danio rerio

Alignment Length:	573	Identity:	221/573 - (38%)
Similarity:	311/573 - (54%)	Gaps:	47/573 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ACLLLAIVGFVGA--------TEWWESGNYYQIYPRSFRDSDGDGIGDLNGVTEKLQYLKDIGFT 63
            || .||::....|        ..||:....||:|||||:||:.||:|||.|:.|||.:.:.:...
Zfish    85 AC-TLALIAMTAAIVALSPRCMSWWQLSPIYQVYPRSFKDSNADGVGDLRGIKEKLSHFEYLNIK 148

  Fly    64 GTWLSPIFKSPMVDFGYDISDFYQIHPEYGTMEDFERMIAKAKEVGIKIILDFVPNHSSTENEWF 128
            ..|:||.:||||.|||||:.||..:.|.:||||||:.::....:.|:|:|:|::|||:|.::.||
Zfish   149 AIWISPFYKSPMRDFGYDVEDFRDVDPLFGTMEDFDDLLTSMHDKGLKLIMDYIPNHTSDKHVWF 213

  Fly   129 TKSVDSDPVYKDFYIWHDGKINNETGEREPPSNWNSEFRYSAWEWNEVRQQYYLHQFAIQQADLN 193
            ..|.:....|.|:|||     .|.|.::. |:||.|.|..|.||::|:|||.|.|||..:|.|||
Zfish   214 QLSRNYTEPYTDYYIW-----VNCTADKH-PNNWVSVFGNSTWEYDEIRQQCYFHQFLKEQPDLN 272

  Fly   194 YRNPAVVNEMKNVIRFWLGKGVSGFRIDAVPYLFEVDLDRYNQYPDEPLTNDSVNCPDPDDHCYT 258
            ||||.|:.||.::|.|||.|||.|||:|||.::.|.     ....|||..|...:....|.....
Zfish   273 YRNPLVLQEMTDIIHFWLKKGVDGFRMDAVKHMLEA-----THLRDEPQVNPDQDPSTVDTEFEL 332

  Fly   259 QHIYTQDMPETIDMVYQWRELVDEFHVENGGDKRLLMTEAYTSFENI---MTYYGNGVRNGSHIP 320
            .|.||.......:::..||..:|.:..| .|..|.::.|:| .:|.|   |.|||......|..|
Zfish   333 YHDYTYTQAGLHEILTDWRIQMDTYSRE-PGRYRFMVMESY-DYEEIDKTMRYYGTNYAKESDFP 395

  Fly   321 FNFDFLTSINNASKAGEYVEHI-KKWMDAMPEGVYANWVLGNHDNKRVASRFGVQRTDLINILLQ 384
            |||..|...:|.|  |.|.:.| ::||..||:|.:.|||:||||..|:.|..|.:....:|:||.
Zfish   396 FNFYLLDLPDNLS--GNYAKSIVERWMSNMPKGKWPNWVVGNHDKPRIGSSAGKEYVRALNMLLL 458

  Fly   385 TLPGHAVTYNGEELGMTDVWISWEDTVDPNACNSDPDNYYARSRDPARSPYQWDASSKAGFT-SA 448
            ||||...||.|||:||.||.||   .:...|...||    ::||||.|:|.||:....|||: |.
Zfish   459 TLPGTPTTYYGEEIGMVDVNIS---VIQDPAGQYDP----SKSRDPQRTPMQWNNELNAGFSESL 516

  Fly   449 DHTWLPVADDYKTNNALQQLRAPRSHLQIFKKLVRVR-KEPSFRQGELNIQAIDDDVIIYSRQKT 512
            :.|||.:|.||:|.|...|.....|.:..::.|..:| ......:|.......|.:|..|.|:..
Zfish   517 NGTWLDIASDYRTVNVEVQQDDTSSTISQYRALSLLRSSNVILSRGWFCYVWNDVNVFAYLRELD 581

  Fly   513 G-SDLYVIVLNLGSTSKTLDLTKYYELGTQAEVITTSLSSQYIDGDVIKSTEF 564
            | |..:::|||.|..: |.||:...||   .:.:|..||:     :.|..|||
Zfish   582 GLSKGFLVVLNFGKET-TTDLSSVKEL---PDSLTLHLST-----ESITQTEF 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A1	NP_476627.3	AmyAc_maltase	21..496	CDD:200467	194/480 (40%)
Mal-A1	NP_476627.3	Alpha-amylase	45..404	CDD:278554	150/362 (41%)
slc3a1	XP_021336428.1	SLC3A2_N	55..113	CDD:318284	7/28 (25%)
slc3a1	XP_021336428.1	AmyAc_SLC3A1	106..563	CDD:200494	193/478 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	311	1.000	Domainoid score	I1286
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
OMA	1	1.010	-	-		QHG53234
OrthoDB	1	1.010	-	-		D1384693at2759
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	O	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880