DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A1 and amy2al1

DIOPT Version :9

Sequence 1:	NP_476627.3	Gene:	Mal-A1 / 35824	FlyBaseID:	FBgn0002570	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_956722.1	Gene:	amy2al1 / 393400	ZFINID:	ZDB-GENE-040426-1606	Length:	512	Species:	Danio rerio

Alignment Length:	550	Identity:	115/550 - (20%)
Similarity:	184/550 - (33%)	Gaps:	162/550 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 QYLKDIGFTGTWLSPIFKS--------PMVDFGYDISDFYQIHPEYGTMEDFERMIAKAKEVGIK 111
            :||...|:.|..:||..:|        |.......||  |.:....||.|:.:.|||:...||:.
Zfish    45 RYLAPNGYGGVQISPPSESIVLTKPWHPWWQRYQPIS--YNLCSRSGTEEELKDMIARCNNVGVN 107

  Fly   112 IILDFVPNH--SSTENEWFTKSVDSDPVYKDFYIWHDGKINNETGEREPPSNWNSEFRYSAWEWN 174
            |..|.|.||  .::..|....|.              |...|...|..|      ...||:|::|
Zfish   108 IYADAVINHMCGASGGEGTHSSC--------------GTYFNAKNEDFP------SVPYSSWDFN 152

  Fly   175 EVR-------QQYYLHQFAIQQADL----------NYRNPAVVNEMKNVIRFWLGKGVSGFRIDA 222
            :.:       .:.|...|.::...|          :|....|...|..:|..    ||:|||:||
Zfish   153 DNKCKTANEDIENYSDIFQVRDCRLVSLLDLALEKDYVRGKVAEYMNKLIDI----GVAGFRVDA 213

  Fly   223 VPYLFEVDLDRYNQYPDEPLTNDSVNCPDPDDHCYTQHIYTQDMPETIDMVYQWRELVDEFHVEN 287
            ..:::..||.  |.|......|:                 |...|.|...:||  |::|     .
Zfish   214 CKHMWPGDLS--NVYSRLKTLNN-----------------TWFSPGTKPFIYQ--EVID-----L 252

  Fly   288 GGDKRLLMTEAYTSFENIMTYYGNGVRNGSHIPFNFDFLTSINNASKAGEYVE--------HIKK 344
            ||:.  :....|.|...:                     |....::|.|..:.        ::|.
Zfish   253 GGEP--IKASEYVSLGRV---------------------TEFKYSAKLGTVIRKWEKEKLCYLKN 294

  Fly   345 WMDA---MPEGVYANWVLGNHDNKR-----VASRFGVQRTDLINILLQTLPGHAVTYNGEELGMT 401
            |.:.   ||......:| .||||:|     .||......:.|..|....:..|       ..|:|
Zfish   295 WGEGWGFMPSDKALVFV-DNHDNQRGHGAGGASVLTFWDSRLYKIATGLMLAH-------PYGVT 351

  Fly   402 DVWIS--WEDTVDPNACNSDPDNYYARSRDP---ARSPYQWDASSKAGFTSADHTWLPVADDYKT 461
            .|..|  |             |.::...:|.   ...|...|.|:|:...:.|.|   ..|::..
Zfish   352 AVMSSYRW-------------DRHFVNGKDQNDWMGPPSNADGSTKSVPINPDST---CGDNWIC 400

  Fly   462 NNALQQLRAPRSHLQIFKKLVRVRKEPSFRQGELNIQAIDDDVIIYSRQKTGSDLYVIVLNLGST 526
            .:..:|:|    ::..|:.:  |..:|.....:.|     ::.|.:||...|    .||:|....
Zfish   401 EHRWRQIR----NMVNFRNV--VNGQPLSNWWDNN-----NNQIAFSRGSKG----FIVINNNDW 450

  Fly   527 SKTLDLTKYYELGTQAEVITTSLSSQYIDG 556
            ...:.|......||..::|:...|.....|
Zfish   451 DLNVMLKTGLPSGTYCDIISGDKSGNSCTG 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A1	NP_476627.3	AmyAc_maltase	21..496	CDD:200467	101/488 (21%)
Mal-A1	NP_476627.3	Alpha-amylase	45..404	CDD:278554	84/391 (21%)
amy2al1	NP_956722.1	AmyAc_bac_euk_AmyA	25..417	CDD:200456	99/476 (21%)
		AmyA	46..>315	CDD:223443	73/344 (21%)
		Aamy_C	424..511	CDD:214749	13/65 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810