DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A1 and Mal-A8

DIOPT Version :9

Sequence 1:	NP_476627.3	Gene:	Mal-A1 / 35824	FlyBaseID:	FBgn0002570	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_610384.1	Gene:	Mal-A8 / 35830	FlyBaseID:	FBgn0033297	Length:	588	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	286/539 - (53%)
Similarity:	380/539 - (70%)	Gaps:	6/539 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EWWESGNYYQIYPRSFRDSDGDGIGDLNGVTEKLQYLKDIGFTGTWLSPIFKSPMVDFGYDISDF 85
            :||::..:||||||||:||||||||||||:|.||:||||:|.|..||||||||||||||||||||
  Fly    32 DWWQTAQFYQIYPRSFKDSDGDGIGDLNGITSKLEYLKDLGVTAAWLSPIFKSPMVDFGYDISDF 96

  Fly    86 YQIHPEYGTMEDFERMIAKAKEVGIKIILDFVPNHSSTENEWFTKSVDSDPVYKDFYIWHDGKIN 150
            :.|.|||||:|||..:|.:|||:.:||:|||||||||.|:|||.|||..:..|:|:|:|||||:|
  Fly    97 FDIQPEYGTLEDFRTLIKRAKELDLKIVLDFVPNHSSNESEWFLKSVKREKGYEDYYVWHDGKVN 161

  Fly   151 NETGEREPPSNWNSEFRYSAWEWNEVRQQYYLHQFAIQQADLNYRNPAVVNEMKNVIRFWLGKGV 215
            :.||:||||:||...||.||||||||||||||||||:||.|||||||.||.:||.|:|:||.:||
  Fly   162 STTGKREPPTNWLQYFRGSAWEWNEVRQQYYLHQFAVQQPDLNYRNPLVVEQMKRVLRYWLNEGV 226

  Fly   216 SGFRIDAVPYLFEVDLDRYNQYPDEPLTNDSVNCPDPDDHCYTQHIYTQDMPETIDMVYQWRELV 280
            ||||.||:|.||||..|...|:|||.::..:   .|.:|..|....|.::.|||||||||||.::
  Fly   227 SGFRCDALPPLFEVVPDSDGQFPDEVVSGAT---EDKEDRDYLTTTYIENQPETIDMVYQWRTVL 288

  Fly   281 DEFHVENGGDKRLLMTEAYTSFENIMTYYGNGVRNGSHIPFNFDFLTSINNAS-KAGEYVEHIKK 344
            |:.....||:..:|:.|.|:.....|.:|||....|:|:||||:.:|.:..:. .|....|.|..
  Fly   289 DDHKRIFGGNSSVLLIETYSPAWFTMQFYGNRSTEGAHLPFNFNLITVMEQSGLSASNVQEAIDL 353

  Fly   345 WMDAMPEGVYANWVLGNHDNKRVASRFGVQRTDLINILLQTLPGHAVTYNGEELGMTDVWISWED 409
            |:..||.|...||||||||.:|.|||:|.:..|.:|:|:..|||.:|||.|||:||||..|||||
  Fly   354 WLKNMPAGRTPNWVLGNHDKRRAASRYGKENIDGMNMLVMILPGVSVTYQGEEIGMTDGEISWED 418

  Fly   410 TVDPNACNSDPDNYYARSRDPARSPYQWDASSKAGFTSADHTWLPVADDYKTNNALQQLRAPRSH 474
            ||||..|||:|:.|...:|||.|:|:||...:.||||:...||||:|.||.|.|..::|....||
  Fly   419 TVDPWGCNSNPNIYEQYTRDPERTPFQWTGGTNAGFTNGSSTWLPLAADYATINVEKELSDDHSH 483

  Fly   475 LQIFKKLVRVRK-EPSFRQGELNIQAIDDDVIIYSRQKTGSDLYVIVLNLGSTSKTLDLTKYYEL 538
            |:|:|.||.:|| ..:.:.|....||:.:|:.:..|..|.|...|:|:|.||.:||:||:::.:.
  Fly   484 LKIYKALVALRKSSKTLQNGSTKYQALSEDIFVVQRSLTKSATIVLVINFGSVAKTVDLSQFDKS 548

  Fly   539 GTQA-EVITTSLSSQYIDG 556
            .|:: :::..|:.|...:|
  Fly   549 RTESLQLLIRSIDSTKKEG 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A1	NP_476627.3	AmyAc_maltase	21..496	CDD:200467	267/476 (56%)
Mal-A1	NP_476627.3	Alpha-amylase	45..404	CDD:278554	205/359 (57%)
Mal-A8	NP_610384.1	AmyAc_maltase	30..506	CDD:200467	267/476 (56%)
		trehalose_treC	33..585	CDD:274115	286/538 (53%)
		Malt_amylase_C	487..585	CDD:295440	25/81 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	11	10.870