DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A1 and Mal-A5

DIOPT Version :9

Sequence 1:	NP_476627.3	Gene:	Mal-A1 / 35824	FlyBaseID:	FBgn0002570	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_610382.2	Gene:	Mal-A5 / 35828	FlyBaseID:	FBgn0050359	Length:	630	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	295/564 - (52%)
Similarity:	395/564 - (70%)	Gaps:	8/564 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VGFVGA-TEWWESGNYYQIYPRSFRDSDGDGIGDLNGVTEKLQYLKDIGFTGTWLSPIFKSPMVD 77
            :|..|| .:||::..:||||||||:||:|||:|||||:.|:|.|||::|.|.|||||||.|||.|
  Fly    35 IGDHGADLKWWQTAAFYQIYPRSFKDSNGDGVGDLNGIAEQLPYLKELGITATWLSPIFTSPMAD 99

  Fly    78 FGYDISDFYQIHPEYGTMEDFERMIAKAKEVGIKIILDFVPNHSSTENEWFTKSVDSDPVYKDFY 142
            |||||::|.:|.|.:|||.|||.::..||::.|||||||||||||.|.|||.:|...||.:||||
  Fly   100 FGYDIANFTEIAPIFGTMADFEHLMEVAKKLDIKIILDFVPNHSSDECEWFRRSAARDPEFKDFY 164

  Fly   143 IWHDGKINNETGEREPPSNWNSEFRYSAWEWNEVRQQYYLHQFAIQQADLNYRNPAVVNEMKNVI 207
            :||.|::.|  |.|.|||||.|.||.|||:|:|.||::|||||..:|.|||||||.|...|.||:
  Fly   165 VWHPGRMEN--GNRHPPSNWISVFRGSAWQWHEGRQEFYLHQFVKKQPDLNYRNPKVRETMSNVL 227

  Fly   208 RFWLGKGVSGFRIDAVPYLFEVDLDRYNQYPDEPLTNDSVNCPDPDDHCYTQHIYTQDMPETIDM 272
            ||||||||:||||||||::||:..|..|||.||| .||..|  ||:|:.|.|||||:|.|||||:
  Fly   228 RFWLGKGVAGFRIDAVPHVFEIAPDNQNQYRDEP-RNDWDN--DPEDYGYLQHIYTKDQPETIDL 289

  Fly   273 VYQWRELVDEFHVENGGDKRLLMTEAYTSFENIMTYYGNGVRNGSHIPFNFDFLTSINNASKAGE 337
            ||.||.::|....|:||:.|:||.|.|:..:.:|.||||....|:.:||||..::.::|:|.|..
  Fly   290 VYSWRAVLDAHQREHGGEDRILMAETYSPIDIVMQYYGNATAEGAQLPFNFLLISELSNSSNAHA 354

  Fly   338 YVEHIKKWMDAMPEGVYANWVLGNHDNKRVASRFGVQRTDLINILLQTLPGHAVTYNGEELGMTD 402
            |...:.||:..||:|..|||||||||..||.||.|..|.|::|:|..||||.:|||.|||||||:
  Fly   355 YEGTVLKWLQHMPKGRTANWVLGNHDQPRVGSRLGRDRVDMLNMLTATLPGASVTYQGEELGMTN 419

  Fly   403 VWISWEDTVDPNACNSDPDNYYARSRDPARSPYQWDASSKAGFTSADHTWLPVADDYKTNNALQQ 467
            |||||:|||||:|||::|..|...||||.|:|:||..:..|||::|..||||:|.|||..|..|:
  Fly   420 VWISWKDTVDPSACNTNPSIYEQYSRDPERTPFQWTDAQDAGFSNASKTWLPIAVDYKEVNVEQE 484

  Fly   468 LRAPRSHLQIFKKLVRVRKE-PSFRQGELNIQAIDDDVIIYSRQKTGSDLYVIVLNLGSTSKTLD 531
            .:.|.|||.:||:|.::||: .:.::||..::|:.|.|:...|.......|:.:||:....:|::
  Fly   485 RQKPLSHLNVFKQLWQLRKQSQTLKRGETEVKALSDAVLAVKRYLERDSTYLTLLNIYDGVETIN 549

  Fly   532 LTKYY-ELGTQAEVITTSLSSQYIDGDVIKSTEFVANPYVGTVL 574
            |.:.: :|..|.:|:..:..||...||::.||.....|....||
  Fly   550 LLQSFPDLPPQLKVVVVTERSQVKVGDLVNSTSLQLQPKDSLVL 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A1	NP_476627.3	AmyAc_maltase	21..496	CDD:200467	271/475 (57%)
Mal-A1	NP_476627.3	Alpha-amylase	45..404	CDD:278554	208/358 (58%)
Mal-A5	NP_610382.2	AmyAc_maltase	41..514	CDD:200467	271/477 (57%)
Mal-A5	NP_610382.2	Alpha-amylase	67..421	CDD:278554	208/358 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	11	10.870