DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A1 and Mal-A4

DIOPT Version :9

Sequence 1:	NP_476627.3	Gene:	Mal-A1 / 35824	FlyBaseID:	FBgn0002570	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_610381.1	Gene:	Mal-A4 / 35827	FlyBaseID:	FBgn0033294	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	284/566 - (50%)
Similarity:	386/566 - (68%)	Gaps:	7/566 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LAIVGFVGATEWWESGNYYQIYPRSFRDSDGDGIGDLNGVTEKLQYLKDIGFTGTWLSPIFKSPM 75
            |.::....|..||::.::||||||||:||||:|:||||||||||:|||:||.|.|||||..||||
  Fly    13 LGLLAVDAAAPWWKTASFYQIYPRSFKDSDGNGVGDLNGVTEKLEYLKEIGVTATWLSPFLKSPM 77

  Fly    76 VDFGYDISDFYQIHPEYGTMEDFERMIAKAKEVGIKIILDFVPNHSSTENEWFTKSVDSDPVYKD 140
            .|||||||||..:.|.:|||||||.|:::|||:|:||||||||||||.|.:||.:|...:..|||
  Fly    78 ADFGYDISDFKAVDPLFGTMEDFENMVSRAKELGVKIILDFVPNHSSDECDWFLRSAAGEEEYKD 142

  Fly   141 FYIWHDGKINNETGEREPPSNWNSEFRYSAWEWNEVRQQYYLHQFAIQQADLNYRNPAVVNEMKN 205
            :|:||.|.: :|.|.|.||:||.|.||.|||||:|.||:||||||..:|.|.|:|||.|..||.|
  Fly   143 YYMWHPGFL-DEDGTRRPPTNWVSVFRGSAWEWHEGRQEYYLHQFHKKQPDFNFRNPVVREEMNN 206

  Fly   206 VIRFWLGKGVSGFRIDAVPYLFEVDLDRYNQYPDEPLTNDSVNCPDPDDHCYTQHIYTQDMPETI 270
            |:||||.|||.|||:||:.:.||::.|....||||| .||..|  |||::.||..|||.|.|||.
  Fly   207 VLRFWLEKGVDGFRVDAIYHAFEIEADENGNYPDEP-RNDWTN--DPDEYGYTHKIYTVDQPETP 268

  Fly   271 DMVYQWRELVDEFHVENGGDKRLLMTEAYTSFENIMTYYGNGVRNGSHIPFNFDFLTSINNASKA 335
            .:||:||:::::|..:||||:|:||.|.::..|.:|.||||...:|:.|||||..:::::..|.|
  Fly   269 HLVYEWRQILEQFQADNGGDERILMVETWSPIEIVMHYYGNETADGAQIPFNFQLISNLHYDSDA 333

  Fly   336 GEYVEHIKKWMDAMPEGVYANWVLGNHDNKRVASRFGVQRTDLINILLQTLPGHAVTYNGEELGM 400
            ..|...|..|::.||||..||||:||||..||.||||..|.||.||||.||||.::||.||||||
  Fly   334 YHYEYLINNWLNLMPEGKSANWVIGNHDKNRVGSRFGADRVDLFNILLLTLPGCSITYQGEELGM 398

  Fly   401 TDVWISWEDTVDPNACNSDPDNYYARSRDPARSPYQWDASSKAGFTSADHTWLPVADDYKTNNAL 465
            .|.::||||||||.|||....||...||||||:|..|...:.||||:.:.|||||:.||:..|..
  Fly   399 LDGYVSWEDTVDPQACNGYEANYMDNSRDPARTPMHWSDETMAGFTTGNSTWLPVSTDYRQRNVK 463

  Fly   466 QQLRAPRSHLQIFKKLVRVRKEPSFRQGELNIQAIDDDVIIYSRQKTGSDLYVIVLNLGSTSKTL 530
            .:.....|||.:||:|.::|:|||..:|...::|:.:.|:...|..:|..:|:.:.|:..:.:.:
  Fly   464 TERGVSLSHLNVFKRLQQLRQEPSIEEGSAEVKAVSNYVLAVKRHLSGDFVYISLFNIFDSIENV 528

  Fly   531 DLTKYY-ELGTQAE-VITTSLSSQYIDGDVIKSTEFVANPYVGTVL 574
            :|:..: .|..:.: .:.|..|.:.: ||.:.:......|:...||
  Fly   529 NLSSVFGSLPAKFQYALVTEKSIKKV-GDQVSAGSVTLMPHESIVL 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A1	NP_476627.3	AmyAc_maltase	21..496	CDD:200467	267/474 (56%)
Mal-A1	NP_476627.3	Alpha-amylase	45..404	CDD:278554	208/358 (58%)
Mal-A4	NP_610381.1	AmyAc_maltase	24..492	CDD:200467	266/471 (56%)
Mal-A4	NP_610381.1	Alpha-amylase	47..401	CDD:278554	207/357 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	11	10.870