DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A1 and Mal-A3

DIOPT Version :9

Sequence 1:	NP_476627.3	Gene:	Mal-A1 / 35824	FlyBaseID:	FBgn0002570	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_476628.2	Gene:	Mal-A3 / 35826	FlyBaseID:	FBgn0002571	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	286/572 - (50%)
Similarity:	387/572 - (67%)	Gaps:	6/572 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ACLLLAIVGFVGATEWWESGNYYQIYPRSFRDSDGDGIGDLNGVTEKLQYLKDIGFTGTWLSPIF 71
            :|||...:..:....||::|.:||||||||:||||||:|||.|:|::|.|||:||.|.|||||||
  Fly     8 SCLLALALPSLAEVGWWKTGQFYQIYPRSFKDSDGDGVGDLIGITQQLPYLKEIGITATWLSPIF 72

  Fly    72 KSPMVDFGYDISDFYQIHPEYGTMEDFERMIAKAKEVGIKIILDFVPNHSSTENEWFTKSVDSDP 136
            .|||.|||||::|...|.|.:|||||||.::|:|||:.|||||||||||:|.|.:||.:|...:.
  Fly    73 TSPMADFGYDVADLKGIDPIFGTMEDFEALLARAKELDIKIILDFVPNHTSDECDWFIRSAAGEE 137

  Fly   137 VYKDFYIWHDGKINNETGEREPPSNWNSEFRYSAWEWNEVRQQYYLHQFAIQQADLNYRNPAVVN 201
            .|||||:||.||:.|  |.|:||:||.|.||.|.|.|||.||.||||||..:|.|||||||.||.
  Fly   138 EYKDFYVWHTGKVVN--GIRQPPTNWVSVFRGSMWTWNEQRQAYYLHQFHAKQPDLNYRNPKVVE 200

  Fly   202 EMKNVIRFWLGKGVSGFRIDAVPYLFEVDLDRYNQYPDEPLTNDSVNCPDPDDHCYTQHIYTQDM 266
            .||:|:||||.||..||||||||:::|:..|....:|||| .|::|:  ||:|:.|.|||||.|.
  Fly   201 AMKDVLRFWLRKGAYGFRIDAVPHVYEIPADADGNWPDEP-RNEAVS--DPEDYTYLQHIYTTDQ 262

  Fly   267 PETIDMVYQWRELVDEFHVENGGDKRLLMTEAYTSFENIMTYYGNGVRNGSHIPFNFDFLTSINN 331
            |||:::||.:|::::|...|.|||.|:|:||||:..|.:|.|||||...||.|||||:.|..|:.
  Fly   263 PETLELVYAFRDVIEEIDAELGGDDRVLLTEAYSPLEVLMQYYGNGTHLGSQIPFNFELLAKISY 327

  Fly   332 ASKAGEYVEHIKKWMDAMPEGVYANWVLGNHDNKRVASRFGVQRTDLINILLQTLPGHAVTYNGE 396
            :|.|..|.|.|..|:|.||||..||||.||||..|:.||.|..|.|..|:::..|||.:|||.||
  Fly   328 SSDAYHYSELIHNWLDNMPEGQVANWVFGNHDQSRIGSRLGADRIDACNMIILGLPGVSVTYQGE 392

  Fly   397 ELGMTDVWISWEDTVDPNACNSDPDNYYARSRDPARSPYQWDASSKAGFTSADHTWLPVADDYKT 461
            |:|||||||||||||||.||.|:...:...:|||.|:|:||.....|||::|..||||||.:||.
  Fly   393 EMGMTDVWISWEDTVDPQACQSNEQEFERLTRDPVRTPFQWSDEVNAGFSNASVTWLPVASNYKL 457

  Fly   462 NNALQQLRAPRSHLQIFKKLVRVRKEPSFRQGELNIQAIDDDVIIYSRQKTGSDLYVIVLNLGST 526
            .|..::.....|||.::|:|..:|.||:.:||::::.||..:|:.:.|...|...|:.::|:...
  Fly   458 VNVKKERGIALSHLNVYKQLRALRDEPTLKQGDVSVTAIGPNVLAFKRSLAGYKSYITLININDD 522

  Fly   527 SKTLDLTKYY-ELGTQAEVITTSLSSQYIDGDVIKSTEFVANPYVGTVLVAV 577
            .::::|...: .:.||.:.:..:..|.....|:..:...:..|....||..|
  Fly   523 VESINLDSVFTSITTQLQYVVVNDKSVRRKNDLTFANSVLLLPKEAVVLSTV 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A1	NP_476627.3	AmyAc_maltase	21..496	CDD:200467	267/474 (56%)
Mal-A1	NP_476627.3	Alpha-amylase	45..404	CDD:278554	206/358 (58%)
Mal-A3	NP_476628.2	AmyAc_maltase	22..490	CDD:200467	266/472 (56%)
Mal-A3	NP_476628.2	Alpha-amylase	46..400	CDD:278554	206/358 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	11	10.870