DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A1 and Mal-B2

DIOPT Version :9

Sequence 1:	NP_476627.3	Gene:	Mal-A1 / 35824	FlyBaseID:	FBgn0002570	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_001188791.2	Gene:	Mal-B2 / 34598	FlyBaseID:	FBgn0032382	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	281/562 - (50%)
Similarity:	370/562 - (65%)	Gaps:	24/562 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EWWESGNYYQIYPRSFRDSDGDGIGDLNGVTEKLQYLKDIGFTGTWLSPIFKSPMVDFGYDISDF 85
            :||....:||||||||:||:|||||||.|:|.||:||.|.|.|.|||||||:|||:||||||||:
  Fly    33 DWWPHTVFYQIYPRSFKDSNGDGIGDLKGITSKLRYLADTGITATWLSPIFQSPMIDFGYDISDY 97

  Fly    86 YQIHPEYGTMEDFERMIAKAKEVGIKIILDFVPNHSSTENEWFTKSVDSDPVYKDFYIWHDGKIN 150
            ..|.||||||:|||.:|..|.|:|||::|||||||||.::|||.||...:|.|:|||:|||| |.
  Fly    98 KAIQPEYGTMQDFEELIDTAFELGIKVVLDFVPNHSSDQHEWFKKSAAREPGYEDFYVWHDG-IV 161

  Fly   151 NETGEREPPSNWNSEFRYSAWEWNEVRQQYYLHQFAIQQADLNYRNPAVVNEMKNVIRFWLGKGV 215
            .|.|.|.||:||.|.|..|||||:|.|:|||||||..:|.|||||||.||..|.:|:.|||.|||
  Fly   162 QENGTRVPPNNWPSVFYGSAWEWHEGREQYYLHQFTKEQPDLNYRNPKVVQAMDDVLLFWLNKGV 226

  Fly   216 SGFRIDAVPYLFEVDLDRYNQYPDEPL---TNDSVNCPDPDDHCYTQHIYTQDMPETIDMVYQWR 277
            :|||||||.:|||.:     ...||||   |.||::      :.||:|||::|:||.::|::.||
  Fly   227 AGFRIDAVNHLFEDE-----SLKDEPLSGKTTDSLS------YDYTKHIYSRDLPEVLEMIHHWR 280

  Fly   278 ELVDEF---HVENGGDKRLLMTEAYTSFENIMTYY--GNGVRNGSHIPFNFDFLTSINNASKAGE 337
            :|:|:|   |.|.  ..|::|||||.....:..||  .|||| |||:||||.|:|.:...|.|.:
  Fly   281 QLLDDFSAKHPER--PTRIMMTEAYAGLTQLADYYEDSNGVR-GSHLPFNFHFITDVKGDSDARD 342

  Fly   338 YVEHIKKWMDAMPEGVYANWVLGNHDNKRVASRFGVQRTDLINILLQTLPGHAVTYNGEELGMTD 402
            ||.:::||:..||.|..||||:|||||.|||||||....|.:|:||.||||.|||||||||||.|
  Fly   343 YVYNVEKWLIYMPRGHAANWVMGNHDNPRVASRFGPASVDAMNMLLLTLPGVAVTYNGEELGMVD 407

  Fly   403 V-WISWEDTVDPNACNSDPDNYYARSRDPARSPYQWDASSKAGFTSADHTWLPVADDYKTNNALQ 466
            . .:|||:||||.|.|.....|...||||.|:|:||:..:.|||::|..|||||..:|...|...
  Fly   408 YRELSWEETVDPPARNVGEKLYQEVSRDPVRTPFQWNNETNAGFSTAAKTWLPVHPNYLELNLEA 472

  Fly   467 QLRAPRSHLQIFKKLVRVRKEPSFRQGELNIQAIDDDVIIYSRQKTGSDLYVIVLNLGSTSKTLD 531
            |..|.|||.|::|.|:.:||....|.|..||:.:...|..:.|.....:..:.|:|:....:.:|
  Fly   473 QKVANRSHYQVYKDLLELRKSAIMRVGRFNIEPLTRWVFAFKRSYPNFESIITVINVSDKEQLVD 537

  Fly   532 LTKYYELGTQAEVITTSLSSQYIDGDVIKSTEFVANPYVGTV 573
            |:::.....:..|..:.:.|:|..|..:.::..:.....|.|
  Fly   538 LSEFLSQPKKLVVEVSGVDSKYQPGQSLAASALLLAAREGLV 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A1	NP_476627.3	AmyAc_maltase	21..496	CDD:200467	267/483 (55%)
Mal-A1	NP_476627.3	Alpha-amylase	45..404	CDD:278554	210/367 (57%)
Mal-B2	NP_001188791.2	AmyAc_maltase	33..502	CDD:200467	267/483 (55%)
Mal-B2	NP_001188791.2	Malt_amylase_C	510..>541	CDD:351862	6/30 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	9	8.970