Protein Alignment Mal-A1 and AMY2B

DIOPT Version :9

• Sequence 1: NP_476627.3
• Gene: Mal-A1 / 35824
• FlyBaseID: FBgn0002570
• Length: 577
• Species: Drosophila melanogaster
• Sequence 2: NP_001373038.1
• Gene: AMY2B / 280
• HGNCID: 478
• Length: 511
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 108/575 - (18%)
• Similarity: 190/575 - (33%)
• Gaps: 215/575 - (37%)

  Fly    55 QYLKDIGFTGTWLSPIFKS--------PMVDFGYDISDFYQIHPEYGTMEDFERMIAKAKEVGIK 111
            :||...||.|..:||..::        |..:....:|  |::....|..::|..|:.:...||::
Human    45 RYLAPKGFGGVQVSPPNENVAIHNPFRPWWERYQPVS--YKLCTRSGNEDEFRNMVTRCNNVGVR 107

  Fly   112 IILDFVPNH----------SSTENEWFTKSVDSDPVYKDF-------YIWHDGKINNETGEREPP 159
            |.:|.|.||          |||...:|      :|..:||       :.::|||....:|:.|
Human   108 IYVDAVINHMSGNAVSAGTSSTCGSYF------NPGSRDFPAVPYSGWDFNDGKCKTGSGDIE-- 164

  Fly   160 SNWNSEFRYSAWEWNEVR--QQYYLHQFAIQQADLNYRNPAVVNEMKNVIRFWLGKGVSGFRIDA 222
             |:|        :..:||  :...|...|:::   :|....:...|.::|..    ||:|||:||
Human   165 -NYN--------DATQVRDCRLVGLLDLALEK---DYVRSKIAEYMNHLIDI----GVAGFRLDA 213

  Fly   223 VPYLFEVDLDRYNQYPDEPLTNDSVNCPDPDDHCYTQHIYTQDMPETIDMVYQWRELVDEFHVEN 287
                                               ::|::..|:          :.::|:.|..|
Human   214 -----------------------------------SKHMWPGDI----------KAILDKLHNLN 233

  Fly   288 -----GGDKRLLMTEAY-TSFENIMT--YYGNGVRNGSHIPFNFDFLTSINNASKA--------G 336
                 .|.|..:..|.. ...|.|.:  |:|||            .:|.....:|.        |
Human   234 SNWFPAGSKPFIYQEVIDLGGEPIKSSDYFGNG------------RVTEFKYGAKLGTVIRKWNG 286

  Fly   337 EYVEHIKKWMDA---MPEG---VYANWVLGNHDNKRVASRFGVQRTDLINILLQTLPGHAVTYNG 395
            |.:.::|.|.:.   ||..   |:.:    ||||:|                     ||..
Human   287 EKMSYLKNWGEGWGFMPSDRALVFVD----NHDNQR---------------------GHGA---- 322

  Fly   396 EELGMTDVWISWEDTVDPNACNSDPDNYYARSRDPARSPYQWDASSKAGFTSADHTWLPVADDYK 460
               |...:...|:..:...|......:.|..:|  ..|.|:|..                  .::
Human   323 ---GGASILTFWDARLYKMAVGFMLAHPYGFTR--VMSSYRWPR------------------QFQ 364

  Fly   461 TNNALQQLRAPRSHLQIFKKLV------------------RVRKEPSFR-----QGELNIQAIDD 502
            ..|.:.....|.::..:.|::.                  ::|...:||     |...|......
Human   365 NGNDVNDWVGPPNNNGVIKEVTINPDTTCGNDWVCEHRWRQIRNMVNFRNVVDGQPFTNWYDNGS 429

  Fly   503 DVIIYSRQKTGSDLYVIVLNLGSTSKTLDLTKYYELGTQAEVITTSLSSQYIDGD 557
            :.:.:.|...|    .||.|....:.:|.|......||..:||    |...|:|:
Human   430 NQVAFGRGNRG----FIVFNNDDWTFSLTLQTGLPAGTYCDVI----SGDKINGN 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A1	NP_476627.3	AmyAc_maltase	21..496	CDD:200467	93/512 (18%)
		Alpha-amylase	45..404	CDD:278554	79/397 (20%)
AMY2B	NP_001373038.1	AmyAc_bac_euk_AmyA	25..416	CDD:200456	92/505 (18%)
		PLN02447	<85..>155	CDD:215246	18/75 (24%)
		Aamy_C	422..510	CDD:214749	15/63 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810