Protein Alignment Mal-A1 and AMY1C

DIOPT Version :10

• Sequence 1: NP_476627.3
• Gene: Mal-A1 / 35824
• FlyBaseID: FBgn0002570
• Length: 577
• Species: Drosophila melanogaster
• Sequence 2: NP_001008220.1
• Gene: AMY1C / 278
• HGNCID: 476
• Length: 511
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 114/571 - (19%)
• Similarity: 193/571 - (33%)
• Gaps: 207/571 - (36%)

  Fly    55 QYLKDIGFTGTWLSPIFKS--------PMVDFGYDISDFYQIHPEYGTMEDFERMIAKAKEVGIK 111
            :||...||.|..:||..::        |..:....:|  |::....|..::|..|:.:...||::
Human    45 RYLAPKGFGGVQVSPPNENVAIHNPFRPWWERYQPVS--YKLCTRSGNEDEFRNMVTRCNNVGVR 107

  Fly   112 IILDFVPNH----------SSTENEWFTKSVDSDPVYKDF-------YIWHDGKINNETGEREPP 159
            |.:|.|.||          |||...:|      :|..:||       :.::|||....:|:.|
Human   108 IYVDAVINHMCGNAVSAGTSSTCGSYF------NPGSRDFPAVPYSGWDFNDGKCKTGSGDIE-- 164

  Fly   160 SNWNSEFRYSAWEWNEVRQQYYLHQFAIQQADLNYRNPAVVNEMKNVIRFWLGKGVSGFRIDAVP 224
             |:|     .|.:..:.|....|        ||......|.:::...:...:..||:||||||..
Human   165 -NYN-----DATQVRDCRLSGLL--------DLALGKDYVRSKIAEYMNHLIDIGVAGFRIDASK 215

  Fly   225 YLFEVD----LDRY-----NQYPD--EPLTNDSVNCPDPDDHCYTQHIYTQDMPETIDMVYQWRE 278
            :::..|    ||:.     |.:|:  :|                              .:||  |
Human   216 HMWPGDIKAILDKLHNLNSNWFPEGSKP------------------------------FIYQ--E 248

  Fly   279 LVDEFHVENGGDKRLLMTEAYTSFENIMTYYGNGVRNGSHIPFNFDFLTSINNASKA-------- 335
            ::|     .||       |...|.:    |:|||            .:|.....:|.
Human   249 VID-----LGG-------EPIKSSD----YFGNG------------RVTEFKYGAKLGTVIRKWN 285

  Fly   336 GEYVEHIKKWMDA---MPEG---VYANWVLGNHDNKRVASRFGVQRTDLINILLQTLPGHAVTYN 394
            ||.:.::|.|.:.   ||..   |:.:    ||||:|                     ||..
Human   286 GEKMSYLKNWGEGWGFMPSDRALVFVD----NHDNQR---------------------GHGA--- 322

  Fly   395 GEELGMTDVWISWEDTVDPNACNSDPDNYYARSRDPARSPYQWDASSKAGFTSADHTWLP----- 454
                |...:...|:..:...|......:.|..:|  ..|.|:|....:.|....|....|
Human   323 ----GGASILTFWDARLYKMAVGFMLAHPYGFTR--VMSSYRWPRYFENGKDVNDWVGPPNDNGV 381

  Fly   455 -----------VADDYKTNNALQQLRAPRSHLQIFKKLVRVRKEPSFRQGELNIQAIDD--DVII 506
                       ..:|:...:..:|:|    ::..|:.:|         .|:......|:  :.:.
Human   382 TKEVTINPDTTCGNDWVCEHRWRQIR----NMVNFRNVV---------DGQPFTNWYDNGSNQVA 433

  Fly   507 YSRQKTGSDLYVIVLNLGSTSKTLDLTKYYELGTQAEVITTSLSSQYIDGD 557
            :.|...|    .||.|....:.:|.|......||..:||    |...|:|:
Human   434 FGRGNRG----FIVFNNDDWTFSLTLQTGLPAGTYCDVI----SGDKINGN 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A1	NP_476627.3	AmyAc_maltase	21..496	CDD:200467	99/506 (20%)
AMY1C	NP_001008220.1	AmyAc_bac_euk_AmyA	25..416	CDD:200456	97/492 (20%)
		Aamy_C	422..510	CDD:214749	15/63 (24%)