DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mal-A1 and SPCC11E10.09c

DIOPT Version :9

Sequence 1:	NP_476627.3	Gene:	Mal-A1 / 35824	FlyBaseID:	FBgn0002570	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_001342914.1	Gene:	SPCC11E10.09c / 2539049	PomBaseID:	SPCC11E10.09c	Length:	478	Species:	Schizosaccharomyces pombe

Alignment Length:	570	Identity:	120/570 - (21%)
Similarity:	195/570 - (34%)	Gaps:	207/570 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 WESGNYYQIYPRSFR-DSD---GDGIGDL------NGVTEKLQYLKDIGFTGTWLSPIFK--SPM 75
            |.....||:....|. |.|   ....|:|      .|:|..|.|:|.:|.|..|:|||.|  |..
pombe    19 WRKQVIYQVLTDRFALDEDNFYAKASGNLYLGGTWKGITRNLDYIKSLGCTAIWISPIVKNISET 83

  Fly    76 VD-----FGYDISDFYQIHPEYGTMEDFERMIAKAKEVGIKIILDFVPNHSSTENEWFTKSVDSD 135
            .|     .||...|..|::..:||.||.:.::....|..:..::|.|.||..        ...|.
pombe    84 TDCGQAYHGYWAQDMTQLNENFGTEEDLKELVNAIHEKNMLCMVDIVVNHMG--------HAGSK 140

  Fly   136 PVYKDFYIWHDGKINNETGEREPPSNWNSEFRYSAWEWNEVRQQY---------YLHQFAIQQAD 191
            ||  :|.::            :|   :||...|..|::   .|.|         :|....:...|
pombe   141 PV--NFLLY------------QP---FNSGKYYHNWQF---VQNYDDPHETITGWLGDSHVNLPD 185

  Fly   192 LNYRNPAVVNEMKNVIRFWLGKGV-----SGFRIDAVPYL----FEVDLDRYNQYPDEPLTNDSV 247
            :....    ||::...:.|:...:     .|.|:|...::    |...::..|.:     |...|
pombe   186 IRTEK----NEVRKFFQNWVSDLIKRYQFDGIRLDTAKHVEKSFFPTFIEAANVF-----TTGEV 241

  Fly   248 NCPDP---DDHCYTQHIYTQDMPETID--MVYQWRE-LVDEFHVENGGDKRLLMTEAYTSFENIM 306
            ...||   .|       |.:.:|.|::  :.:|.|| .:|..|                   ::.
pombe   242 FHGDPKVVGD-------YQKYLPSTLNFPLFFQLRETFLDPKH-------------------SMF 280

  Fly   307 TYYGNGVRNGSHIPFNFDFLTSINNASKAGEYVEHIKKWMDAMPEGVYANWVLGNHDNKRVASRF 371
            ::|...|.:..|.   |..:|.:.|                          .|.|||    ..||
pombe   281 SFYDKAVLDVRHY---FKDVTVLCN--------------------------FLENHD----FPRF 312

  Fly   372 GVQRTDL---INIL--LQTLPGHAVTYNGEELGMTDVWISWEDTVDPNACNSDPDNYYARSRDPA 431
            ..:..|:   :|.|  |..:.|..:.|.|:| .|.|             ..|||||
pombe   313 FHETKDIALALNALTALIFMDGIPIIYYGQE-QMFD-------------GGSDPDN--------- 354

  Fly   432 RSPYQWDASSKAGFTSADHTWLPVADDYKTNNALQQLRAPRSHLQIFKKLVRVRKE-----PSFR 491
                            .:..|   ...|.|:|.:.:      ||   ..::|.|:.     |.|.
pombe   355 ----------------REGLW---KSKYNTSNPMFR------HL---SSMIRTRQNLVETYPEFT 391

  Fly   492 QGELNIQA-IDDDVIIYSRQKTGSDLYVIVLNLGSTSK---TLDLTKYYE 537
            . .|:.|. |||.|.:::|    ..:.:.:.|.||||.   .:||.::::
pombe   392 Y-VLSFQLYIDDSVYVFTR----PGVIIAISNEGSTSSFKVEIDLKEHWK 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A1	NP_476627.3	AmyAc_maltase	21..496	CDD:200467	106/523 (20%)
Mal-A1	NP_476627.3	Alpha-amylase	45..404	CDD:278554	85/400 (21%)
SPCC11E10.09c	NP_001342914.1	AmyAc_euk_AmyA	19..384	CDD:200458	104/511 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0366
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810