DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mal-A1 and Mal-A6

DIOPT Version :9

Sequence 1:	NP_476627.3	Gene:	Mal-A1 / 35824	FlyBaseID:	FBgn0002570	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_724679.2	Gene:	Mal-A6 / 246565	FlyBaseID:	FBgn0050360	Length:	601	Species:	Drosophila melanogaster

Alignment Length:	609	Identity:	294/609 - (48%)
Similarity:	392/609 - (64%)	Gaps:	53/609 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AACLLLAIVGFVGAT------------------EWWESGNYYQIYPRSFRDSDGDGIGDLNGVTE 52
            ||.|:|.|...:|:.                  :||:...:|||||||::||||||||||.|:..
  Fly     9 AAILVLGIHCALGSAAAVDLDLERATTAADTTRDWWQVAQFYQIYPRSYKDSDGDGIGDLQGIIS 73

  Fly    53 KLQYLKDIGFTGTWLSPIFKSPMVDFGYDISDFYQIHPEYGTMEDFERMIAKAKEVGIKIILDFV 117
            ||.|||:||.|.||||||:.|||.|||||||||:.|.|||||:.||:.:||:||:..||||||||
  Fly    74 KLDYLKEIGVTATWLSPIYSSPMADFGYDISDFFDIQPEYGTLADFDELIAEAKKRNIKIILDFV 138

  Fly   118 PNHSSTENEWFTKSVDSDPVYKDFYIWHDGKINNETGEREPPSNWNSEFRYSAWEWNEVRQQYYL 182
            |||||.||.||.|||..:..|:|:|:||||.:|..||:|||||||...||.||||||:.||||||
  Fly   139 PNHSSDENVWFQKSVKREKGYEDYYMWHDGYVNATTGKREPPSNWLQAFRGSAWEWNDERQQYYL 203

  Fly   183 HQFAIQQADLNYRNPAVVNEMKNVIRFWLGKGVSGFRIDAVPYLFEVDLDRYNQYPDEPLTNDSV 247
            ||||::|.||||||||||.:||.|:.:||.:||:|||:||||:.|||..|...:||||||:..:
  Fly   204 HQFAVKQPDLNYRNPAVVAQMKRVLTYWLDRGVAGFRMDAVPWCFEVLPDADGRYPDEPLSGYT- 267

  Fly   248 NCPDPDDHCYTQHIYTQDMPETIDMVYQWRELVDEFHVENGGDKRLLMTEAYTSFENIMTYYGNG 312
              .||||..|.:||||||:.||::||:|||.|:|::...:|||.|::|.|.|:..:.:|.:|||.
  Fly   268 --DDPDDSSYLKHIYTQDLRETVEMVFQWRTLLDDYQRIHGGDTRVIMVETYSGLDYVMQFYGNR 330

  Fly   313 VRNGSHIPFNFDFL---------TSINNASKAGEYVEHIKKWMDAMPEGVYANWVLGNHDNKRVA 368
            ...|:.:||||.|:         |.:|    |..:|:.|..|:..||.|..||||:||||.:||.
  Fly   331 TTKGAQMPFNFQFIIGGNGDKNNTQLN----ATGFVKIISSWLSQMPAGQTANWVMGNHDQRRVG 391

  Fly   369 SRFGVQRTDLINILLQTLPGHAVTYNGEELGMTDVWISWEDTVDPNACNSDPDNYYARSRDPARS 433
            ||:|..|.||:|:|...|||.::||.||||||||:.|||||:.||.||||:.|.|...:|||||:
  Fly   392 SRYGENRIDLMNMLQMFLPGVSITYQGEELGMTDLDISWEDSRDPAACNSNSDIYEQFTRDPART 456

  Fly   434 PYQWDASSKAGFTSADHTWLPVADDYKTNNALQQLRAPRSHLQIFKKLVRVRKEPSFRQGELNIQ 498
            |:||...:.|||::...||||:..:|.|.||..:.....|||.::|:||.:||..:.:.|.....
  Fly   457 PFQWSDEANAGFSTNATTWLPINPNYVTVNAKAENSTSPSHLSLYKQLVDLRKSKTLQFGATRYA 521

  Fly   499 AIDDDVIIYSRQKTGSDLYVIVLNLGSTSKT-LDL------TKYYE---LGTQAEVITTSLSSQY 553
            .:.|:|:...|..:|...||:|.|:..||.: :|:      |..|:   |..||:...
  Fly   522 NVGDNVVAIRRYLSGEPSYVLVANVLDTSVSGIDVASAIYATGSYKIKLLNPQAKATV------- 579

  Fly   554 IDGDVIKSTEFVANPYVGTVLVAV 577
              ||.:..:.....||...:|.:|
  Fly   580 --GDSVTLSNLTLEPYAALILESV 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mal-A1	NP_476627.3	AmyAc_maltase	21..496	CDD:200467	266/483 (55%)
Mal-A1	NP_476627.3	Alpha-amylase	45..404	CDD:278554	209/367 (57%)
Mal-A6	NP_724679.2	AmyAc_maltase	40..516	CDD:200467	265/482 (55%)
Mal-A6	NP_724679.2	trehalose_treC	43..599	CDD:274115	286/571 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I4622
eggNOG	1	0.900	-	-		E1_COG0366
Homologene	1	1.000	-	-		H113646
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111733at6656
OrthoFinder	1	1.000	-	-		FOG0000282
OrthoInspector	1	1.000	-	-		mtm6539
orthoMCL	1	0.900	-	-		OOG6_100402
Panther	1	1.100	-	-	P	PTHR10357
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X202
	11	10.870