DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e2 and DIT2

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_010690.1	Gene:	DIT2 / 852011	SGDID:	S000002810	Length:	489	Species:	Saccharomyces cerevisiae

Alignment Length:	518	Identity:	113/518 - (21%)
Similarity:	209/518 - (40%)	Gaps:	103/518 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNP--------------SEILDT-VFSW 62
            |.|:.:|.||......::...|.|:.:|.:         |              :|:.|. :...
Yeast     7 LCLILFLTLSYVAFAIIVPPLNFPKNIPTI---------PFYVVFLPVIFPIDQTELYDLYIRES 62

  Fly    63 WHQYGKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSD-----IYQLTHPWLGLGLLTSTGS 122
            ..:||...|.|  |:..|:||:.|:||..|...:....||.     .|.....:.|..::::.|:
Yeast    63 MEKYGAVKFFF--GSRWNILVSRSEYLAQIFKDEDTFAKSGNQKKIPYSALAAYTGDNVISAYGA 125

  Fly   123 KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHL--KTVAAGDNIFDFQEQAHYLTLDVICDT 185
            .|..:|..:|     |.||.|.:.....:.|.:..|  ..:..|.........:..:.||.|...
Yeast   126 VWRNYRNAVT-----NGLQHFDDAPIFKNAKILCTLIKNRLLEGQTSIPMGPLSQRMALDNISQV 185

  Fly   186 AMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEI 250
            |:|....|:.:..:    ||.:....|..:.|||.........:.| .|:..:..|.:..| .|:
Yeast   186 ALGFDFGALTHEKN----AFHEHLIRIKKQIFHPFFLTFPFLDVLP-IPSRKKAFKDVVSF-REL 244

  Fly   251 IAKRIEAHKSGAVSTNAGDEFTR----KKMAFLDTLLSSTIDGRPLNSKELYEEVSTFMFEGHDT 311
            :.||::            ||...    ::..|..:.|....:...::.|:|.:.:...:..||:.
Yeast   245 LVKRVQ------------DELVNNYKFEQTTFAASDLIRAHNNEIIDYKQLTDNIVIILVAGHEN 297

  Fly   312 TTSGVSFAVYLLSRHQDE-QRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSV 375
            .....:.::|||:::.:| |.||   ::||.|.::.      :.::.:..|:.|:.|..|:||.:
Yeast   298 PQLLFNSSLYLLAKYSNEWQEKL---RKEVNGITDP------KGLADLPLLNAFLFEVVRMYPPL 353

  Fly   376 -PFIGRFTEKDYVIDGDLV-PKGTTLNLGLVMLGYNEKVFKDPH----------KFRPERF--EL 426
             ..|.|.|.|...:..::| |||       |.:|||.  |...|          .|:|||:  ::
Yeast   354 STIINRCTTKTCKLGAEIVIPKG-------VYVGYNN--FGTSHDPKTWGTTADDFKPERWGSDI 409

  Fly   427 E--------KPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNF--EVLPALDELVSKDG 479
            |        .........|..|.|.|:|:|.||.|::..::::::.|  .:.|..:|.::..|
Yeast   410 ETIRKNWRMAKNRCAVTGFHGGRRACLGEKLALTEMRISLAEMLKQFRWSLDPEWEEKLTPAG 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	104/484 (21%)
DIT2	NP_010690.1	CYP56-like	65..485	CDD:410693	102/451 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900