DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e2 and CYP86C4

DIOPT Version :9

Sequence 1:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_172774.1	Gene:	CYP86C4 / 837873	AraportID:	AT1G13150	Length:	529	Species:	Arabidopsis thaliana

Alignment Length:	548	Identity:	126/548 - (22%)
Similarity:	231/548 - (42%)	Gaps:	89/548 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LYIFLALPLLLVAYLELSTF--RRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQYG 67
            ||..|:|..||::.|.|..|  .|.::.|| .||...|:.|...:...:    ::.|:.|..:..
plant     7 LYNHLSLFDLLLSLLGLFVFCCLREKLTNK-RGPMLWPVFGITLEFFFH----INDVYGWVTRSL 66

  Fly    68 K---DNFVF---WI-GTYSNVLVTSSKYLEFILSS------QTLITKSDIYQLTHPWLGLGLLTS 119
            |   ..|::   |: |:|..|....:. :|::|.:      :....||....|    |..|:..:
plant    67 KKCRGTFLYRGVWLDGSYGAVTCVPAN-VEYMLKTNFKNFPKGTFFKSRFNDL----LEEGIFNA 126

  Fly   120 TGSKWHKHRKMITPAFHFN--ILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVI 182
            ....|.:.|::|....|..  :...|....:....|.:|.:::.|.....||.|:....||.|:|
plant   127 DDDSWKEQRRIIITEMHSTGFVEHSFQTTQHLVRKKLLKVMESFAKSQEAFDLQDVFLRLTFDII 191

  Fly   183 CDTAMGVSINAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDY---------PAYSR 238
            |...:|.....:......:..|          :||.....:.|...:.|.:         ..|.:
plant   192 CLAGLGADPETLAVDLPQVPFA----------KAFEEATESTLFRFMIPPFIWKPMRFLDTGYEK 246

  Fly   239 TLK----TLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTR-------KKMAFLDTLLSSTIDGRPL 292
            .|:    .:..|.:::|..||...|......|..|..:|       |:...:|          |.
plant   247 GLRIAVGVVHGFVDKMIVDRICELKEEETLDNRSDVLSRIIQIESHKRENEID----------PS 301

  Fly   293 NSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVM---GNSELGRDA---T 351
            ..:...:..::|:..|.||::..:|:..:::.:|.:.:.|:..|.||::   |:|...::.   |
plant   302 TIRFFRQFCTSFILAGRDTSSVALSWFCWVIQKHPEVENKIICEIREILRQRGDSPTSKNESLFT 366

  Fly   352 FQEISQMKYLDLFIKEAQRVYPSVPF-IGRFTEKDYVIDGDLVPKGTTLNLGLVMLGYNEKVF-K 414
            .:|::.|.||...:.|..|::|.:|. :.:..|.|.:.||..|.||:.:...:..:|..|.:: |
plant   367 VKELNNMVYLQAALSETLRLFPPIPMEMKQAIEDDVLPDGTFVRKGSRVYFSIYAMGRMESIWGK 431

  Fly   415 DPHKFRPERF----ELEKPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELV 475
            |...|||||:    :......|:||.|:||||.|||:.||.|::|.:.:.::..:.:....|.::
plant   432 DCEIFRPERWIQAGKFVSDDQFKYVVFNAGPRLCIGKTFAYLQMKMIAASVLLRYSIKVVQDHVI 496

  Fly   476 S---------KDGYISTTIGLPDAERKK 494
            :         |.| :..||.....|.||
plant   497 APRVTTNLYMKYG-LKVTITPRSLEEKK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	106/480 (22%)
CYP86C4	NP_172774.1	CYP86A	73..510	CDD:410687	102/462 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010